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Targets Recommended: Carboxypeptidase

10000

抑制剂 & 化合物

1000+

天然产物

17

化合物库

94

TargetMol 试剂盒

363

重组蛋白

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Cat. No. Product Name
L2000 抑制剂库

7618 compounds
7618 个小分子抑制剂的独特集合,主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选;
L9100 磷酸酶抑制剂化合物库

80 compounds
80 种已知活性的磷酸酶抑制剂的集合,可用于化合物筛选、化学基因组学、药理分析等方面;
L1600 激酶抑制剂库

2230 compounds
2230 种激酶抑制剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选;
L7600 趋化因子抑制剂库

59 compounds
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选;
L9410 共价抑制剂库

1949 compounds
1949 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发;
L3600 细胞因子抑制剂库

613 compounds
613 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体;
L9400 PPI抑制剂库

490 compounds
490 种已知活性的 PPI 相关的抑制剂,可用于高通量、高内涵筛选;
L1400 MAPK 抑制剂库

367 compounds
367 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选;
L1100 蛋白酶抑制剂库

344 compounds
344 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选;
L2200 酪氨酸激酶分子库

1033 compounds
1033 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选;
L2300 离子通道库

946 compounds
946 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选;
L1610 FDA 上市激酶抑制剂库

280 compounds
TargetMol FDA 上市激酶库包含280 个具有明确激酶抑制活性的上市药物
L2010 高选择性抑制剂库

580 compounds
xunm种具有高选择性的抑制剂集合
L1510 核受体化合物库

546 compounds
546 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选;
L8000 干细胞分化化合物库

1213 compounds
1213 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选;
L7000 活性脂质化合物库

385 compounds
385 种生物活性小分子化合物,用于高通量、高内涵筛选;
L7110 抗高血压化合物库

719 compounds
719 种高血压相关的小分子,用于高通量和高内涵筛选;

化合物库

抑制剂库
L2000
Compounds: 7618
磷酸酶抑制剂化合物库
L9100
Compounds: 80
激酶抑制剂库
L1600
Compounds: 2230
趋化因子抑制剂库
L7600
Compounds: 59
共价抑制剂库
L9410
Compounds: 1949
细胞因子抑制剂库
L3600
Compounds: 613
PPI抑制剂库
L9400
Compounds: 490
MAPK 抑制剂库
L1400
Compounds: 367
蛋白酶抑制剂库
L1100
Compounds: 344
酪氨酸激酶分子库
L2200
Compounds: 1033
离子通道库
L2300
Compounds: 946
FDA 上市激酶抑制剂库
L1610
Compounds: 280
高选择性抑制剂库
L2010
Compounds: 580
核受体化合物库
L1510
Compounds: 546
干细胞分化化合物库
L8000
Compounds: 1213
活性脂质化合物库
L7000
Compounds: 385
抗高血压化合物库
L7110
Compounds: 719
Cat. No. Product Name Form Specificity Of Inhibition
C0002 Phosphatase Inhibitor Cocktail I (100× ddH2O)

磷酸酶抑制剂 Cocktail I

Solution (100× in ddH2O) Acid Phosphatase, Alkaline phosphatase, PTPs, ATPases
C0003 Phosphatase Inhibitor Cocktail II (100× DMSO)

磷酸酶抑制剂 Cocktail II

Solution (100× in DMSO) Alkaline phosphatases, Ser/Thr phosphatases, Acid and PP1 and PP2A
C0004 Phosphatase Inhibitor Cocktail III (2 Tubes, 100x)

磷酸酶抑制剂 Cocktail III

2 Tube Solution (100×) Each Tube has different specificity of inhibition
C0001 Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO)

蛋白酶抑制剂 Cocktail

Solution (EDTA-Free,100× in DMSO) Serine proteases, Aminopeptidases, Cysteine proteases, Aspartic proteases
CL0064 PDE inhibitor kit

PDE inhibitor kit

CL0140 BTK inhibitor kit

BTK inhibitor kit

CL0128 HMGCR inhibitor kit

HMGCR inhibitor kit

CL0131 SGLT inhibitor kit

SGLT inhibitor kit

C0048 Deacetylase Inhibitor Cocktail (100× in 70% DMSO)

去乙酰化酶抑制剂 Cocktail(100× in 70% DMSO)

Solution (100× in 70% DMSO) Class I/II/III HDAC
CL0142 MMP inhibitor kit

MMP inhibitor kit

CL0121 ALK inhibitor kit

ALK inhibitor kit

CL0045 COX inhibitor kit

COX inhibitor kit

CL0116 MAO inhibitor kit

MAO inhibitor kit

CL0056 CDK inhibitor kit

CDK inhibitor kit

CL0114 ERK inhibitor kit

ERK inhibitor kit

CL0109 Ras inhibitor kit

Ras inhibitor kit

CL0139 ROS inhibitor kit

ROS inhibitor kit

CL0084 FGFR inhibitor kit

FGFR inhibitor kit

CL0069 JAK inhibitor kit

JAK inhibitor kit

CL0071 PDGFR inhibitor kit

PDGFR inhibitor kit

CL0091 MEK inhibitor kit

MEK inhibitor kit

CL0130 DUB inhibitor kit

DUB inhibitor kit

CL0052 HDAC inhibitor kit

HDAC inhibitor kit

CL0081 Phosphatase inhibitor kit

Phosphatase inhibitor kit

CL0062 Topoisomerase inhibitor kit

Topoisomerase inhibitor kit

CL0072 BET inhibitor kit

BET inhibitor kit

CL0127 NOS inhibitor kit

NOS inhibitor kit

CL0100 Raf inhibitor kit

Raf inhibitor kit

CL0085 HSP inhibitor kit

HSP inhibitor kit

CL0132 DHFR inhibitor kit

DHFR inhibitor kit

CL0133 CXCR inhibitor kit

CXCR inhibitor kit

CL0087 mTOR inhibitor kit

mTOR inhibitor kit

CL0098 HER2 inhibitor kit

HER2 inhibitor kit

CL0083 Dehydrogenase inhibitor kit

Dehydrogenase inhibitor kit

CL0101 STAT inhibitor kit

STAT inhibitor kit

CL0125 AChE inhibitor kit

AChE inhibitor kit

CL0058 EGFR inhibitor kit

EGFR inhibitor kit

CL0068 VEGFR inhibitor kit

VEGFR inhibitor kit

CL0146 JNK inhibitor kit

JNK inhibitor kit

CL0112 PKC inhibitor kit

PKC inhibitor kit

CL0093 PARP inhibitor kit

PARP inhibitor kit

CL0122 ACE inhibitor kit

ACE inhibitor kit

CL0135 ROCK inhibitor kit

ROCK inhibitor kit

CL0077 Reverse Transcriptase inhibitor kit

Reverse Transcriptase inhibitor kit

CL0102 Akt inhibitor/activator kit

Akt inhibitor/activator kit

CL0129 Aurora Kinase inhibitor kit

Aurora Kinase inhibitor kit

CL0076 PPAR inhibitor/activator kit

PPAR inhibitor/activator kit

CL0138 Carbonic Anhydrase inhibitor kit

Carbonic Anhydrase inhibitor kit

CL0094 FLT3 inhibitor kit

FLT3 inhibitor kit

CL0066 P450 inhibitor kit

P450 inhibitor kit

CL0094 FLT3 inhibitor kit

FLT3 inhibitor kit

CL0092 GSK-3 inhibitor kit

GSK-3 inhibitor kit

CL0075 c-Kit inhibitor kit

c-Kit inhibitor kit

CL0066 P450 inhibitor kit

P450 inhibitor kit

CL0067 Sodium Channel inhibitor kit

Sodium Channel inhibitor kit

CL0119 Histone Demethylase inhibitor kit

Histone Demethylase inhibitor kit

CL0079 Adenosine Receptor inhibitor kit

Adenosine Receptor inhibitor kit

CL0060 Estrogen Receptor inhibitor kit

Estrogen Receptor inhibitor kit

CL0070 GABA Receptor inhibitor kit

GABA Receptor inhibitor kit

CL0061 Histone Methyltransferase inhibitor kit

Histone Methyltransferase inhibitor kit

CL0141 Notch pathway inhibitor kit

Notch pathway inhibitor kit

CL0123 AMPK inhibitor/activator kit

AMPK inhibitor/activator kit

CL0115 Proton Pump inhibitor kit

Proton Pump inhibitor kit

CL0107 Src inhibitor/activator kit

Src inhibitor/activator kit

CL0074 Microtubule/Tubulin inhibitor kit

Microtubule/Tubulin inhibitor kit

CL0082 TRP Channel inhibitor kit

TRP Channel inhibitor kit

CL0059 Dopamine Receptor inhibitor kit

Dopamine Receptor inhibitor kit

CL0063 Cytoskeleton pathway inhibitor kit

Cytoskeleton pathway inhibitor kit

CL0105 Sirtuin inhibitor/activator kit

Sirtuin inhibitor/activator kit

CL0057 PI3K inhibitor kit

PI3K inhibitor kit

CL0145 Casein Kinase inhibitor kit

Casein Kinase inhibitor kit

CL0055 Potassium Channel inhibitor kit

Potassium Channel inhibitor kit

CL0136 ATM/ATR inhibitor kit

ATM/ATR inhibitor kit

CL0088 Angiotensin Receptor inhibitor kit

Angiotensin Receptor inhibitor kit

CL0149 β-/γ-secretase inhibitor kit

β-/γ-secretase inhibitor kit

CL0147 c-FMS inhibitor kit

c-FMS inhibitor kit

CL0134 p53 inhibitor/reactivator kit

p53 inhibitor/reactivator kit

CL0143 PKA/cAMP inhibitor/activator kit

PKA/cAMP inhibitor/activator kit

CL0078 Glucocorticoid Receptor inhibitor/activator kit

Glucocorticoid Receptor inhibitor/activator kit

CL0150 DNA Methyltransferase/Demethylase inhibitor kit

DNA Methyltransferase/Demethylase inhibitor kit

CL0090 RNA Synthesis inhibitor/activator kit

RNA Synthesis inhibitor/activator kit

CL0073 DNA synthesis inhibitor/activator kit

DNA synthesis inhibitor/activator kit

CL0120 Bcr-Abl inhibitor/degrader kit

Bcr-Abl inhibitor/degrader kit

CL0080 TGFβ signaling pathway inhibitor/activator kit

TGFβ signaling pathway inhibitor/activator kit

CL0089 c-Met/HGFR inhibitor kit

c-Met/HGFR inhibitor kit

CL0053 NF-κB pathway inhibitor kit

NF-κB pathway inhibitor kit

CL0113 ER stress pathway inhibitor/inducer kit

ER stress pathway inhibitor/inducer kit

CL0095 Hedgehog signaling pathway inhibitor/activator kit

Hedgehog signaling pathway inhibitor/activator kit

CL0106 HIF/HIF-PH inhibitor/activator kit

HIF/HIF-PH inhibitor/activator kit

CL0096 Wnt/β-catenin/PORCN inhibitor/activator kit

Wnt/β-catenin/PORCN inhibitor/activator kit

CL0137 E1/E2/E3 Enzyme inhibitor kit

E1/E2/E3 Enzyme inhibitor kit

C0047 RIPA Lysis Buffer (Weak)

RIPA裂解液(弱)

Solution in bottle
C0046 RIPA Lysis Buffer (Middle)

RIPA裂解液(中)

Solution in bottle
C0045 RIPA Lysis Buffer (Strong)

RIPA裂解液(强)

Solution in bottle

TargetMol 试剂盒

磷酸酶抑制剂 Cocktail I
C0002
磷酸酶抑制剂 Cocktail II
C0003
磷酸酶抑制剂 Cocktail III
C0004
蛋白酶抑制剂 Cocktail
C0001
PDE inhibitor kit
CL0064
BTK inhibitor kit
CL0140
HMGCR inhibitor kit
CL0128
SGLT inhibitor kit
CL0131
去乙酰化酶抑制剂 Cocktail(100× in 70% DMSO)
C0048
MMP inhibitor kit
CL0142
ALK inhibitor kit
CL0121
COX inhibitor kit
CL0045
MAO inhibitor kit
CL0116
CDK inhibitor kit
CL0056
ERK inhibitor kit
CL0114
Ras inhibitor kit
CL0109
ROS inhibitor kit
CL0139
FGFR inhibitor kit
CL0084
JAK inhibitor kit
CL0069
PDGFR inhibitor kit
CL0071
MEK inhibitor kit
CL0091
DUB inhibitor kit
CL0130
HDAC inhibitor kit
CL0052
Phosphatase inhibitor kit
CL0081
Topoisomerase inhibitor kit
CL0062
BET inhibitor kit
CL0072
NOS inhibitor kit
CL0127
Raf inhibitor kit
CL0100
HSP inhibitor kit
CL0085
DHFR inhibitor kit
CL0132
CXCR inhibitor kit
CL0133
mTOR inhibitor kit
CL0087
HER2 inhibitor kit
CL0098
Dehydrogenase inhibitor kit
CL0083
STAT inhibitor kit
CL0101
AChE inhibitor kit
CL0125
EGFR inhibitor kit
CL0058
VEGFR inhibitor kit
CL0068
JNK inhibitor kit
CL0146
PKC inhibitor kit
CL0112
PARP inhibitor kit
CL0093
ACE inhibitor kit
CL0122
ROCK inhibitor kit
CL0135
Reverse Transcriptase inhibitor kit
CL0077
Akt inhibitor/activator kit
CL0102
Aurora Kinase inhibitor kit
CL0129
PPAR inhibitor/activator kit
CL0076
Carbonic Anhydrase inhibitor kit
CL0138
FLT3 inhibitor kit
CL0094
P450 inhibitor kit
CL0066
FLT3 inhibitor kit
CL0094
GSK-3 inhibitor kit
CL0092
c-Kit inhibitor kit
CL0075
P450 inhibitor kit
CL0066
Sodium Channel inhibitor kit
CL0067
Histone Demethylase inhibitor kit
CL0119
Adenosine Receptor inhibitor kit
CL0079
Estrogen Receptor inhibitor kit
CL0060
GABA Receptor inhibitor kit
CL0070
Histone Methyltransferase inhibitor kit
CL0061
Notch pathway inhibitor kit
CL0141
AMPK inhibitor/activator kit
CL0123
Proton Pump inhibitor kit
CL0115
Src inhibitor/activator kit
CL0107
Microtubule/Tubulin inhibitor kit
CL0074
TRP Channel inhibitor kit
CL0082
Dopamine Receptor inhibitor kit
CL0059
Cytoskeleton pathway inhibitor kit
CL0063
Sirtuin inhibitor/activator kit
CL0105
PI3K inhibitor kit
CL0057
Casein Kinase inhibitor kit
CL0145
Potassium Channel inhibitor kit
CL0055
ATM/ATR inhibitor kit
CL0136
Angiotensin Receptor inhibitor kit
CL0088
β-/γ-secretase inhibitor kit
CL0149
c-FMS inhibitor kit
CL0147
p53 inhibitor/reactivator kit
CL0134
PKA/cAMP inhibitor/activator kit
CL0143
Glucocorticoid Receptor inhibitor/activator kit
CL0078
DNA Methyltransferase/Demethylase inhibitor kit
CL0150
RNA Synthesis inhibitor/activator kit
CL0090
DNA synthesis inhibitor/activator kit
CL0073
Bcr-Abl inhibitor/degrader kit
CL0120
TGFβ signaling pathway inhibitor/activator kit
CL0080
c-Met/HGFR inhibitor kit
CL0089
NF-κB pathway inhibitor kit
CL0053
ER stress pathway inhibitor/inducer kit
CL0113
Hedgehog signaling pathway inhibitor/activator kit
CL0095
HIF/HIF-PH inhibitor/activator kit
CL0106
Wnt/β-catenin/PORCN inhibitor/activator kit
CL0096
E1/E2/E3 Enzyme inhibitor kit
CL0137
RIPA裂解液(弱)
C0047
RIPA裂解液(中)
C0046
RIPA裂解液(强)
C0045
Cat. No. Product Name Target Signaling Pathways
T10876 CPA inhibitor

Carboxypeptidase inhibitor

Carboxypeptidase Proteases/Proteasome
CPA inhibitor (Carboxypeptidase inhibitor) 是一种有效的羧肽酶 A (CPA) 抑制剂,Ki 值为 0.32 μM。
T2350 MALT1 inhibitor MI-2

MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)

MALT Immunology/Inflammation
MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM),对动物无毒性。它能够直接与 MALT1 结合,不可逆地抑制蛋白酶功能,并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。
T5524 Aurora kinase inhibitor-3

Aurora Kinase Inhibitor III

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) 是一种有效的,选择性 Aurora A 激酶抑制剂,IC50为 42 nM。
T5451 Eph inhibitor 2

Ehp-inhibitor-1

Ephrin Receptor Tyrosine Kinase/Adaptors
Eph inhibitor 2 是一种 Eph 家族酪氨酸激酶抑制剂。
T1804 HPGDS inhibitor 1

HPGDS-inhibitor-1

PGE Synthase Immunology/Inflammation
HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂,在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM,但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。
T4338 USP7/USP47 inhibitor

USP7/47 inhibitor-1

DUB Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
USP7/USP47 inhibitor (USP7/47 inhibitor-1) 是一种选择性泛素特异性蛋白酶 7/47 抑制剂,EC50值分别为 0.42 μM 和 1.0 μM。
T3189 B7/CD28 interaction inhibitor 1

CTLA-4 inhibitor

Others Others
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。
T8766 GOT1 inhibitor-1

GOT1 inhibitor 2c

Others Others
GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM),是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。
T38683 SCD1 inhibitor-3

SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a

Dehydrogenase Metabolism
SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物,可以抑制SCD1,且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常,以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。
T3593 Src Inhibitor 1

Src Kinase Inhibitor 1,Src-l1

Src Angiogenesis; Tyrosine Kinase/Adaptors
Src Inhibitor 1 (Src Kinase Inhibitor 1) 是一种选择性的、高效的、ATP-竞争性的双位点 Src 酪氨酸激酶抑制剂,能够抑制 Src (IC50:44 nM) 和 Lck (IC50:88 nM)。
T5817 PKC-theta inhibitor hcl

PKC-theta inhibitor

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
PKC-theta inhibitor hcl 是一种选择性 PKC-θ 抑制剂 (IC50:12 nM)。
T2074 Raf inhibitor 1

B-Raf inhibitor 1

Raf MAPK
Raf inhibitor 1 (B-Raf inhibitor 1)是Raf 激酶抑制剂,对B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T3042 JAK2 Inhibitor V

JAK2 Inhibitor V Z3,Z3

JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
JAK2 Inhibitor V (JAK2 Inhibitor V Z3) 是一种新型的 Jak2 特异性抑制剂,以剂量依赖性方式抑制 Jak2-V617F 和 Jak2-WT 自磷酸化。
T4191 Multi-kinase inhibitor 1

Multi-kinase inhibitor I

Others; Bcr-Abl; PDGFR; c-Kit Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与c-Kit,PDGF-R,Bcr-abl 活性相关的疾病。
T6335 Tie2 kinase inhibitor 1

Tie2 kinase inhibitor

Tie-2 Tyrosine Kinase/Adaptors
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。
T10678 Carboxypeptidase G2 (CPG2) Inhibitor

CPG2 Inhibitor,Carboxypeptidase G2 Inhibitor

Carboxypeptidase Proteases/Proteasome
Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) 是新型的羧肽酶 G2(CPG2)抑制剂,显示出抗癌活性。
T4391 Syk Inhibitor II dihydrochloride

Syk Inhibitor II (hydrochloride)

Others; Tyrosine Kinases; Syk; PKC; BTK Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
Syk Inhibitor II (hydrochloride) 是一种非受体酪氨酸激酶,磷酸化后,它与 FcRγ 链的基于免疫受体酪氨酸的激活基序结合,并介导与血小板功能和炎症相关的下游信号传导。 Syk inhibitor II 是一种可渗透细胞的嘧啶-甲酰胺化合物,以 ATP 竞争性方式选择性和可逆地阻断 Syk (IC50 = 41 nM)。它对 PKCε、PKCβII、ZAP-70、Btk 和 Itk 的效力要低得多(IC50s 分别为5.1、11、11.2、15.5 和 22.6 μM)。
T2457 IRAK-1-4 Inhibitor I

IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor

IRAK Immunology/Inflammation; NF-κB
IRAK-1-4 Inhibitor I 是一种IRAK1/4双重抑制剂,其IC50分别为 0.2 μM 和 0.3 μM。
T24141 HIV-1 Inhibitor 18A

HIV-1 Inhibitor-18A

HIV Protease Microbiology/Virology; Proteases/Proteasome
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) 特异性抑制多种 HIV-1 分离株的进入。
T35827L PKCε Inhibitor Peptide acetate

PKCε Inhibitor Peptide acetate(182683-50-7 Free base)

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
PKCε Inhibitor Peptide acetate 是一种特异性 PKCε 抑制剂,含有其特定受体活化 C 激酶 (RACK) 的位点。 PKCε Inhibitor Peptide acetate 抑制 PKCε 的转运,但不抑制 αPKC,βPKC 和 δPKC 的转运。
T4491 LMPTP INHIBITOR 1 hydrochloride

LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

Phosphatase Metabolism
LMPTP INHIBITOR 1 hydrochloride 是一种高选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂。LMPTP INHIBITOR 1 (hydrochloride) 能够抑制 LMPTP-A 的活性,IC50值为 0.8 μM。
T67767 HIF-1 inhibitor-4

HIF-1 inhibitor-4

HIF Angiogenesis; Chromatin/Epigenetic
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) 是一种 HIF-1 抑制剂 (IC50: 560 nM)。HIF-1 inhibitor-4 减少 HIF-1α 蛋白水平,但不影响 mRNA 水平。
T4167 Raf inhibitor 1 dihydrochloride

B-Raf inhibitor 1 dihydrochloride

Raf MAPK
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂,对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T9040 Aurora kinase inhibitor-2

IUN-70219,Aurora Kinase Inhibitor II

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
Aurora kinase inhibitor-2 (IUN-70219) 是一种可渗透细胞的苯胺喹唑啉,可抑制极光激酶的活性,对Aurora A 和Aurora B 的IC50分别为 390 nM 和 240 nM。
T21954 EGFR/ErbB-2/ErbB-4 inhibitor-2

EGFR/ErbB2 Inhibitor

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) 是EGFR 和ErbB 的抑制剂,对EGFR、ErbB2 和 ErbB4 的IC50分别为 0.017、0.08 和 1.91 μM。
TP2008L Lyn peptide inhibitor acetate

Lyn peptide inhibitor acetate(222018-18-0 free base)

IL Receptor Immunology/Inflammation
Lyn peptide inhibitor acetate(222018-18-0 free base) 是一种有效的细胞渗透性 Lyn 偶联 IL-5 受体信号通路抑制剂,同时保持其他信号完整。它阻断 Lyn 活化并抑制 Lyn 酪氨酸激酶与 IL-3/GM-CSF/IL-5 受体的 βc 亚基的结合。它可用于哮喘、过敏和其他嗜酸性粒细胞疾病的研究。
T10927 Cyt-PTPε Inhibitor-1

Cyt-PTP|A Inhibitor-1

Phosphatase; Src Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。
T9178 (E/Z)-GSK-3β inhibitor 1

GSK-3β inhibitor 1

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
(E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。它是一种糖原合成酶激酶 3β (GSK-3β)的抑制剂,可其对 GSK-3β 的 IC50=4.9 nM,用于糖尿病的研究。
T17157 TRAF-STOP inhibitor 6877002

CD40-TRAF6 inhibitor

NF-κB NF-κB
TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂,可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化,减少白细胞募集和巨噬细胞的活化,减少动脉粥样硬化斑块中的巨噬细胞增殖。
T36933 Cdk2 Inhibitor II

Cdk2 Inhibitor II,CDK2-IN-3

CDK Cell Cycle/Checkpoint
Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂,50 为 60 nM。
T22081 FBPase-1 inhibitor-1

Fructose 1,6-bisphosphatase-1 Inhibitor

Others Others
FBPase-1 inhibitor-1 (Fructose 1,6-bisphosphatase-1 Inhibitor) 是一种fructose-1,6-bisphosphatase (FBPase-1)的变构抑制剂。
T22136 PRL-3 Inhibitor I

PRL-3 Inhibitor,BR-1

Phosphatase; Others Metabolism; Others
PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂,IC50=0.9 μM。它在细胞检测中显示降低侵袭性。
TP1523 PKG inhibitor peptide TFA (82801-73-8 free base)

PKG inhibitor peptide TFA

PKA Tyrosine Kinase/Adaptors
PKG inhibitor peptide TFA (82801-73-8 free base) 是 ATP 竞争性 cGMP 依赖性蛋白激酶 (PKG) 的抑制剂。
T10865L Cot inhibitor-1 hydrochloride

Cot inhibitor-1 hydrochloride(915365-57-0 Free base)

TNF; MAPK Apoptosis; MAPK
Cot inhibitor-1 hydrochloride 是肿瘤进展位点 2 激酶 (IC50 = 28 nM) 的抑制剂,可抑制人全血中 TNF-α 的产生 (IC50 = 5.7 nM)。
T10599 BRAF inhibitor

Raf MAPK
BRAF inhibitor 是B-Raf 抑制剂,详细信息请参考专利文献 WO2012006552A1 中的化合物 P-0850。
T2649 Menin-MLL inhibitor MI-2

Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase Apoptosis; Chromatin/Epigenetic
Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用,IC50为 446±28 nM。
TP1015 NFAT Inhibitor

VIVIT peptide

Others Others
NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂,能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。
T11184 EML4-ALK kinase inhibitor 1

EML4 ALK kinase inhibitor 1,EML4-​ALK kinase inhibitor 1

ALK Angiogenesis; Tyrosine Kinase/Adaptors
EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) 是有效的、具有口服活性的类棘皮细胞微管相关蛋白4-间变性淋巴瘤激酶 (EML4-ALK) 的抑制剂,其 IC50 值为 1 nM。
T60108 PDGFR Tyrosine Kinase Inhibitor III

PDGF Receptor Tyrosine Kinase Inhibitor III

PDGFR Angiogenesis; Tyrosine Kinase/Adaptors
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III)是一种多激酶抑制剂,可抑制 PDGFR、EGFR、FGFR、PKA 和 PKC 等。PDGFR Tyrosine Kinase Inhibitor III 可用于肌萎缩侧索硬化症的研究。
TP1890L1 MLCK inhibitor peptide 18 acetate

MLCK inhibitor peptide 18 acetate(224579-74-2 free base)

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
MLCK inhibitor peptide 18 acetate(224579-74-2 free base) 是肌球蛋白轻链激酶的选择性竞争性抑制剂 (IC50 = 50 nM)。显示出比 CaM 激酶 II 高 4000 倍的选择性,并且不抑制 PKA。细胞可渗透。
T7541 PTP inhibitor 1

PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Phosphatase Metabolism
PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成作用。
T12502 PLpro inhibitor

5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺

SARS-CoV Microbiology/Virology
PLpro inhibitor 是一种木瓜蛋白酶抑制剂,IC50为 2.6 µM,能抑制 SARS-CoV-2 PLpro。
T2159 CaMKP Inhibitor

CaMK Neuroscience
CaMKP Inhibitor 可以抑制 CaMKP。
T10276L AKT Kinase Inhibitor HCl

AKT Kinase Inhibitor HCl(842148-40-7 Free base)

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
AKT Kinase Inhibitor HCl 是一种 Akt 抑制剂,具有抗肿瘤活性。
T60119 SOD1-Derlin-1 inhibitor-1

SOD1-Derlin-1 Inhibitor 56-20

Others Others
SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) 是 SOD1-Derlin-1相互作用的抑制剂。SOD1-Derlin-1 inhibitor-1 抑制 SOD1G93A-Derlin-1 复合物,IC50值为 7.11 μM。SOD1-Derlin-1 inhibitor-1 可用于肌萎缩性侧索硬化症的研究。
T10463L Bax inhibitor peptide V5 acetate

Bax inhibitor peptide V5 acetate(579492-81-2 free base)

Apoptosis Apoptosis
Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) 是一种 Bax 介导的细胞凋亡抑制剂,用于癌症治疗。
T5452 Ehp-inhibitor-2

Ephrin Receptor Tyrosine Kinase/Adaptors
Ehp-inhibitor-2 是一种靶向 Eph 受体的 Eph 家族酪氨酸激酶抑制剂。
T21521L Papain Inhibitor acetate

乙氨酸-乙氨酸-酪氨酸-精氨酸,GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate (70195-20-9 free base)

Others Others
Papain Inhibitor acetate (Gly-Gly-Tyr-Arg) 是木瓜蛋白酶的亲和配体。
T13224 Tubulin inhibitor 6

iHAP1

Microtubule Associated Cytoskeletal Signaling
Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂,抑制微管蛋白聚合,IC50为 0.87 μM。它抑制多种癌细胞系,抑制 K562 细胞生长,IC50为 840 nM。
T12123 mTOR inhibitor-3

mTOR PI3K/Akt/mTOR signaling
mTOR inhibitor-3 是有效的 mTOR 抑制剂(Ki= 1.5 nM)。在细胞实验及体内实验中,mTOR inhibitor-3 均抑制 mTORC1 和 mTORC2。

化合物

CPA inhibitor
T10876
synonym: Carboxypeptidase inhibitor
Target: Carboxypeptidase
MALT1 inhibitor MI-2
T2350
synonym: MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)
Target: MALT
Aurora kinase inhibitor-3
T5524
synonym: Aurora Kinase Inhibitor III
Target: Aurora Kinase
Eph inhibitor 2
T5451
synonym: Ehp-inhibitor-1
Target: Ephrin Receptor
HPGDS inhibitor 1
T1804
synonym: HPGDS-inhibitor-1
Target: PGE Synthase
USP7/USP47 inhibitor
T4338
synonym: USP7/47 inhibitor-1
Target: DUB
B7/CD28 interaction inhibitor 1
T3189
synonym: CTLA-4 inhibitor
Target: Others
GOT1 inhibitor-1
T8766
synonym: GOT1 inhibitor 2c
Target: Others
SCD1 inhibitor-3
T38683
synonym: SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a
Target: Dehydrogenase
Src Inhibitor 1
T3593
synonym: Src Kinase Inhibitor 1,Src-l1
Target: Src
PKC-theta inhibitor hcl
T5817
synonym: PKC-theta inhibitor
Target: PKC
Raf inhibitor 1
T2074
synonym: B-Raf inhibitor 1
Target: Raf
JAK2 Inhibitor V
T3042
synonym: JAK2 Inhibitor V Z3,Z3
Target: JAK
Multi-kinase inhibitor 1
T4191
synonym: Multi-kinase inhibitor I
Target: Others, Bcr-Abl, PDGFR, c-Kit
Tie2 kinase inhibitor 1
T6335
synonym: Tie2 kinase inhibitor
Target: Tie-2
Carboxypeptidase G2 (CPG2) Inhibitor
T10678
synonym: CPG2 Inhibitor,Carboxypeptidase G2 Inhibitor
Target: Carboxypeptidase
Syk Inhibitor II dihydrochloride
T4391
synonym: Syk Inhibitor II (hydrochloride)
Target: Others, Tyrosine Kinases, Syk, PKC, BTK
IRAK-1-4 Inhibitor I
T2457
synonym: IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor
Target: IRAK
HIV-1 Inhibitor 18A
T24141
synonym: HIV-1 Inhibitor-18A
Target: HIV Protease
PKCε Inhibitor Peptide acetate
T35827L
synonym: PKCε Inhibitor Peptide acetate(182683-50-7 Free base)
Target: PKC
LMPTP INHIBITOR 1 hydrochloride
T4491
synonym: LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))
Target: Phosphatase
HIF-1 inhibitor-4
T67767
synonym: HIF-1 inhibitor-4
Target: HIF
Raf inhibitor 1 dihydrochloride
T4167
synonym: B-Raf inhibitor 1 dihydrochloride
Target: Raf
Aurora kinase inhibitor-2
T9040
synonym: IUN-70219,Aurora Kinase Inhibitor II
Target: Aurora Kinase
EGFR/ErbB-2/ErbB-4 inhibitor-2
T21954
synonym: EGFR/ErbB2 Inhibitor
Target: EGFR
Lyn peptide inhibitor acetate
TP2008L
synonym: Lyn peptide inhibitor acetate(222018-18-0 free base)
Target: IL Receptor
Cyt-PTPε Inhibitor-1
T10927
synonym: Cyt-PTP|A Inhibitor-1
Target: Phosphatase, Src
(E/Z)-GSK-3β inhibitor 1
T9178
synonym: GSK-3β inhibitor 1
Target: GSK-3
TRAF-STOP inhibitor 6877002
T17157
synonym: CD40-TRAF6 inhibitor
Target: NF-κB
Cdk2 Inhibitor II
T36933
synonym: Cdk2 Inhibitor II,CDK2-IN-3
Target: CDK
FBPase-1 inhibitor-1
T22081
synonym: Fructose 1,6-bisphosphatase-1 Inhibitor
Target: Others
PRL-3 Inhibitor I
T22136
synonym: PRL-3 Inhibitor,BR-1
Target: Phosphatase, Others
PKG inhibitor peptide TFA (82801-73-8 free base)
TP1523
synonym: PKG inhibitor peptide TFA
Target: PKA
Cot inhibitor-1 hydrochloride
T10865L
synonym: Cot inhibitor-1 hydrochloride(915365-57-0 Free base)
Target: TNF, MAPK
BRAF inhibitor
T10599
synonym:
Target: Raf
Menin-MLL inhibitor MI-2
T2649
synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2
Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase
NFAT Inhibitor
TP1015
synonym: VIVIT peptide
Target: Others
EML4-ALK kinase inhibitor 1
T11184
synonym: EML4 ALK kinase inhibitor 1,EML4-​ALK kinase inhibitor 1
Target: ALK
PDGFR Tyrosine Kinase Inhibitor III
T60108
synonym: PDGF Receptor Tyrosine Kinase Inhibitor III
Target: PDGFR
MLCK inhibitor peptide 18 acetate
TP1890L1
synonym: MLCK inhibitor peptide 18 acetate(224579-74-2 free base)
Target: Serine/threonin kinase
PTP inhibitor 1
T7541
synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮
Target: Phosphatase
PLpro inhibitor
T12502
synonym: 5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺
Target: SARS-CoV
CaMKP Inhibitor
T2159
synonym:
Target: CaMK
AKT Kinase Inhibitor HCl
T10276L
synonym: AKT Kinase Inhibitor HCl(842148-40-7 Free base)
Target: Akt
SOD1-Derlin-1 inhibitor-1
T60119
synonym: SOD1-Derlin-1 Inhibitor 56-20
Target: Others
Bax inhibitor peptide V5 acetate
T10463L
synonym: Bax inhibitor peptide V5 acetate(579492-81-2 free base)
Target: Apoptosis
Ehp-inhibitor-2
T5452
synonym:
Target: Ephrin Receptor
Papain Inhibitor acetate
T21521L
synonym: 乙氨酸-乙氨酸-酪氨酸-精氨酸,GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate (70195-20-9 free base)
Target: Others
Tubulin inhibitor 6
T13224
synonym: iHAP1
Target: Microtubule Associated
mTOR inhibitor-3
T12123
synonym:
Target: mTOR
Cat. No. Product Name Target Signaling Pathways
T1537 Rapamycin

Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
Rapamycin (AY 22989) 是一种从吸水链霉菌中提取的大环内酯类化合物,是一种有效的特异性 mTOR 抑制剂,在 HEK293 细胞中 IC50 值为0.1 nM。Rapamycin 具有免疫抑制特性,并能诱导自噬。
T3384 Wedelolactone

蟛蜞菊内酯,IKK Inhibitor II

Apoptosis; NF-κB; Lipoxygenase; Caspase Apoptosis; Metabolism; NF-κB; Proteases/Proteasome
Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物,通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录,具有抗癌,抗炎和抗氧化活性。
T14961 Chrysene

䓛,屈

Others Others
Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。
T4953 Neotuberostemonine

NOS Immunology/Inflammation
Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱,能够阻碍巨噬细胞的募集和活化,从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。
T6S1657 Paeonolide

Others Others
Paeonolide 是一种广泛存在于 Paeonia 属植物根中的植物糖苷,含有一个非还原性末端 α-1-阿拉伯吡喃糖苷。
TN1081 Hirsuteine

Dopamine Receptor GPCR/G Protein; Neuroscience
Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物,非竞争性地拮抗烟碱介导的多巴胺释放。
TN1640 Fabiatrin

Others Others
Fabiatrin 是从 Przewalskia tangutica 的正丁醇提取物中分离和鉴定的天然产物。
T5S0661 Koumine

Others Others
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。
T3928 Neoliquiritin

Others Others
Neoliquiritin 是从甘草 Glycyrrhiza uralensis 分离得到,具有抗炎作用。它可能具有细胞毒性和肿瘤特异性。
T7033 Rosmanol

Antioxidant; COX Immunology/Inflammation; Neuroscience; oxidation-reduction
Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达,抑制低密度脂蛋白的氧化,并具有抗炎作用。
T3817 Darutigenol

Others Others
Darutigenol 是一种戊二萜,从Siegesbecikia orientalis L.中分离得到。
TN1816 Kadsurin

Antioxidant oxidation-reduction
Kadsurin 是一种提取自异形南五味子茎中的天然产物,能够显著降低小鼠肝脏中CCL4诱导的脂质过氧化产物(例如TBA-RS、共轭二烯和荧光产物)。
T6S0234 Toosendanin

Others Others
Toosendanin 是一种从杜鹃花果实皮中提取的三萜,具有杀虫和抗炎活性,可用于研究缓解疼痛。
TN2058 Persicogenin

Anti-infection Microbiology/Virology
Persicogenin 是分离自 Rhus retinorrhoea 中,具有抗癌作用。
T3S2027 Rubusoside

Others Others
Rubusoside 是天然的增溶剂及甜味剂,具有良好的抗血管新生和抗过敏药的特性。
T6S1049 Wilforine

ATPase Membrane transporter/Ion channel
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
T19231 Cellulase

Others Others
Cellulase 是一种能够催化纤维素和其他碳水化合物水解的酶。
T13693 Fibrin

Others Others
Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding.
T3A2414 Manninotriose

Others Others
Manninotriose 是小野芝麻主要的碳水化合物(Lamium 象草,唇形科)。
T8161 Vicine

Others Others
Vicine 是一种主要存在于蚕豆中的生物碱糖苷,对人体有毒,可引起溶血性贫血。
T5813 BYAKANGELICIN

Reductase Endocrinology/Hormones; Metabolism
Byakangelicin 是发现于当归根中的一种活性化合物,可作为调节剂,改善各种活性化合物 (Umb,Cur 和 Dox) 的脑积累,增强研究效果。它提高所有PXR 靶基因 (如MDR1) 的表达,并广泛的诱导药物-药物相互作用。它可抑制性激素的作用,可能会增加内源激素的分解代谢。
TJS0851 Plantagoside

Others Others
Plantagoside 是α-mannosidase 的非竞争性特异性抑制剂(IC50:5 μM),分离自Plantago asiatica 种子中。
TN1829 Kakkalide

Dehydrogenase Metabolism
Kakkalide 是提取自葛根花中的一种异黄酮。它可以抑制活性氧相关炎症,并改善内皮细胞胰岛素抵抗作用。
TN1453 Bruceantinol

Anti-infection Microbiology/Virology
Bruceantinol 是一种quassinol 化合物,分离自Brucea javanica 的 CH3OH 提取物。它能够将系统性寄主植物中灭活。有效的抑制浓度为 10 μM。
T8077 Dihydrojasmone

Others Others
Dihydrojasmone 是一种重要的香料成分,是佛手柑油的成分。
T3931 Isobavachin

Others Others
Isobavachin 是一种分离自Psoralea morisiana 中的抗氧化剂,在A 环的8号位置有一个prenyl 基团,具有潜在的促进神经元的分化和其蛋白异戊烯化作用。
TWS1563 Incensole

Others Others
Incensole 是一种 14-membered 二萜类化合物,分离自烯属植物的香精油和乳香树脂中。它能够激活脑中离子通道,并可以缓解焦虑或抑郁,从而显示出抗炎和抗抑郁的特性。
T2903 Cantharidin

Others Others
Cantharidin 是一种天然毒素,分离自拟天牛科及芫菁科,对害虫具有毒害作用。
T19431 Moluccanin

Others Others
Moluccanin 是来自 Aleurites moluccana 的香豆素类。
T3873 griffonilide

Others Others
Griffonilide 是一种提取自Semiaquilegia adoxoides 根中的丁烯内酯类化合物,常与紫草甙一起出现。它是一种传统抗癌药草。
T5S1331 Herbacetin

c-Met/HGFR; Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Herbacetin 是一种亚麻籽中的天然类黄酮,具有多种药理活性,如抗氧化、抗炎、抗癌作用。 它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂,能够直接与 ODC 上的 Asp44,Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
T8208 androsin

Others Others
Androsin 分离于印度胡黄连中,具有抗哮喘作用。
T5777 Phaseoloidin

Others Others
Phaseoloidin 是来自烟草细毛虫的高纯酸苷,有助于植物抵抗鳞翅目草食动物。它能够抑制Manduca sexta 和Spodoptera littoralis 的幼虫生长。它具有抗补体特性。
TN6723 Lactiflorin

Others Others
Lactiflorin 是一种具有肾脏保护作用的单萜苷。
T6S1676 Cimigenoside

Others Others
Cimigenoside 是升麻属中的一种成分。
T14291 Anisindione

Others Others
Anisindione 是合成的抗凝血剂,对活性促凝因子II,VII,IX 和X 的形成具有抑制作用。
TN1982 Neoglycyrol

Others Others
Neoglycyrol 是分离自甘草的根中的化合物。它是由传统专利药通脉养心丸中筛选得到,具有潜在心肌保护作用。
TN1075 Adynerin

Others Others
Adynerin 是一种发现于夹竹桃中的天然类固醇。
TN1626 Eugenin

Others Others
Eugenin 是一种色酮,分离自滨海前胡,能够抗血小板聚集。
TN1923 Mesaconine

IL Receptor; NF-κB Immunology/Inflammation; NF-κB
Mesaconine 是来自 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有心脏作用和抗 NF-κB 活性。 Mesaconine 可能是麻黄附子细辛汤抗炎和免疫抑制的部分物质基础。
TN1800 Isosakuranin

Others Others
Isosakuranin 是一种提取自Paliurus ramosissimus 果实中的天然产物。
T2O2770 Agarotetrol

Others Others
Agarotetrol 是一种色酮衍生物,从沉香中分离得到。
TN1984 Neoisoliquiritin

Others Others
Neoisoliquiritin 是一种提取自甘草中的活性物质。
T6S0525 Farrerol

ERK; p38 MAPK; Akt Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
TN4818 Poriol

Others Others
Poriol 是一种黄酮类化合物,分离自Pseudotsuga sinensis。
T5733 Xylotetraose

Others Others
Xylotetraose 是木聚糖的水解产物,可用于酶生化分析。Xylan 是由木糖单元组成的多糖,主要包含由纤维素连接的 β-D- 木糖单位。
TN1983 Neoisoastilbin

IL Receptor; TNF; NO Synthase Apoptosis; Immunology/Inflammation
Neoisoastilbin 具有抗炎、抗氧化、抗尿酸过多等生物特性。
TN1137 Isobutylshikonin

Others Others
Isobutylshikonin 是分离自Lithospermum canescens 毛状根培养的一种紫草素色素。
TN1455 Bryodulcosigenin

Immunology/Inflammation related Immunology/Inflammation
Bryodulcosigenin 是一种 Bryoniadioica 根的提取物,具有抗炎活性。
TN3548 Bulleyanin

Others Others
Bulleyanin 是从 isodon species (Labiatae) 中分离出来的一种物质。
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天然产物

Rapamycin HOT
T1537
synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804
Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal
Wedelolactone
T3384
synonym: 蟛蜞菊内酯,IKK Inhibitor II
Target: Apoptosis, NF-κB, Lipoxygenase, Caspase
Chrysene
T14961
synonym: 䓛,屈
Target: Others
Neotuberostemonine
T4953
synonym:
Target: NOS
Paeonolide
T6S1657
synonym:
Target: Others
Hirsuteine
TN1081
synonym:
Target: Dopamine Receptor
Fabiatrin
TN1640
synonym:
Target: Others
Koumine
T5S0661
synonym:
Target: Others
Neoliquiritin
T3928
synonym:
Target: Others
Rosmanol
T7033
synonym:
Target: Antioxidant, COX
Darutigenol
T3817
synonym:
Target: Others
Kadsurin
TN1816
synonym:
Target: Antioxidant
Toosendanin
T6S0234
synonym:
Target: Others
Persicogenin
TN2058
synonym:
Target: Anti-infection
Rubusoside
T3S2027
synonym:
Target: Others
Wilforine
T6S1049
synonym:
Target: ATPase
Cellulase
T19231
synonym:
Target: Others
Fibrin
T13693
synonym:
Target: Others
Manninotriose
T3A2414
synonym:
Target: Others
Vicine
T8161
synonym:
Target: Others
BYAKANGELICIN
T5813
synonym:
Target: Reductase
Plantagoside
TJS0851
synonym:
Target: Others
Kakkalide
TN1829
synonym:
Target: Dehydrogenase
Bruceantinol
TN1453
synonym:
Target: Anti-infection
Dihydrojasmone
T8077
synonym:
Target: Others
Isobavachin
T3931
synonym:
Target: Others
Incensole
TWS1563
synonym:
Target: Others
Cantharidin
T2903
synonym:
Target: Others
Moluccanin
T19431
synonym:
Target: Others
griffonilide
T3873
synonym:
Target: Others
Herbacetin
T5S1331
synonym:
Target: c-Met/HGFR, Akt
androsin
T8208
synonym:
Target: Others
Phaseoloidin
T5777
synonym:
Target: Others
Lactiflorin
TN6723
synonym:
Target: Others
Cimigenoside
T6S1676
synonym:
Target: Others
Anisindione
T14291
synonym:
Target: Others
Neoglycyrol
TN1982
synonym:
Target: Others
Adynerin
TN1075
synonym:
Target: Others
Eugenin
TN1626
synonym:
Target: Others
Mesaconine
TN1923
synonym:
Target: IL Receptor, NF-κB
Isosakuranin
TN1800
synonym:
Target: Others
Agarotetrol
T2O2770
synonym:
Target: Others
Neoisoliquiritin
TN1984
synonym:
Target: Others
Farrerol
T6S0525
synonym:
Target: ERK, p38 MAPK, Akt
Poriol
TN4818
synonym:
Target: Others
Xylotetraose
T5733
synonym:
Target: Others
Neoisoastilbin
TN1983
synonym:
Target: IL Receptor, TNF, NO Synthase
Isobutylshikonin
TN1137
synonym:
Target: Others
Bryodulcosigenin
TN1455
synonym:
Target: Immunology/Inflammation related
Bulleyanin
TN3548
synonym:
Target: Others
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Cat. No. Product Name Species Source
TMPY-04815 C1 inhibitor Protein, Rat, Recombinant (His)

serpin peptidase inhibitor, clade G (C1 inhibit...

Rat HEK293
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides ...
TMPY-01183 C1 inhibitor Protein, Human, Recombinant (His)

serpin peptidase inhibitor, clade G (C1 inhibit...

Human HEK293
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides ...
TMPY-01030 TFPI Protein, Human, Recombinant (His)

TFPI1,tissue factor pathway inhibitor (lipoprotein-...

Human HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is...
TMPY-01174 DKK1 Protein, Rhesus, Recombinant (256 Asn/Gln, His)

dickkopf WNT signaling pathway inhibitor 1

Rhesus HEK293
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori...
TMPY-01121 DKK3 Protein, Mouse, Recombinant (His)

dickkopf WNT signaling pathway inhibitor 3,C87148,A...

Mouse HEK293
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its...
TMPY-04811 DKK1 Protein, Mouse, Recombinant (His)

dickkopf WNT signaling pathway inhibitor 1,mdkk-1

Mouse HEK293
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori...
TMPY-06074 B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)

V-set domain containing T cell activation inhibitor...

Cynomolgus,Rhesus HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i...
TMPY-00775 DKK1 Protein, Human, Recombinant (His)

dickkopf WNT signaling pathway inhibitor 1,SK,DKK-1

Human HEK293
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori...
TMPY-02731 SPINK4 Protein, Mouse, Recombinant (hFc)

MPGC60,serine peptidase inhibitor, Kazal type 4,RP2...

Mouse HEK293
Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activit...
TMPY-01474 PAI-1 Protein, Human, Recombinant (His)

PAI,SERPINE1,PAI-1,serpin peptidase inhibitor, clad...

Human HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 def...
TMPY-05322 B7-H4 Protein, Mouse, Recombinant (His)

BC032925,B7h4,B7x,V-set domain containing T cell activation ...

Mouse HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i...
TMPY-00915 SerpinA1 Protein, Human, Recombinant (His)

PRO2275,SerpinA1,serpin peptidase inhibitor, clade ...

Human HEK293
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within li...
TMPY-00916 Antithrombin III Protein, Human, Recombinant (His)

AT3D,THPH7,ATIII,AT3,Serpin C1,MGC22579,serpin peptidase

Human HEK293
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagula...
TMPJ-00916 TIMP-2 Protein, Mouse, Recombinant (His)

metalloproteinase inhibitor 2,Tissue inhibitor<...

Mouse Human Cells
Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi...
TMPJ-00603 TL1A Protein, Mouse, Recombinant

TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V...

Mouse E. coli
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ...
TMPY-03524 B7-H4 Protein, Human, Recombinant (His)

PRO1291,B7X,B7H4,B7-H4,VCTN1,B7S1,B7h.5,V-set domain contain...

Human HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i...
TMPY-02912 TIMP-1 Protein, Rat, Recombinant

TIMP metallopeptidase inhibitor 1

Rat HEK293
TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly ...
TMPY-03876 PTGFRN Protein, Cynomolgus, Recombinant (His)

prostaglandin F2 receptor inhibitor

Cynomolgus HEK293
EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT. EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. EWI-F expression positively correlates with the metastatic status of hLT, and that the upregulation of EWI-F expression could be one of the mechanisms underlying the loss of CD9 in solid tumours.
TMPJ-00490 Serpin A5 Protein, Human, Recombinant (His)

Plasminogen Activator Inhibitor 3,Acrosomal Serine ...

Human Human Cells
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o...
TMPJ-01289 TIMP-4 Protein, Human, Recombinant (His)

TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue <...

Human Human Cells
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
TMPJ-00733 SPINK1 Protein, Human, Recombinant (His)

PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Se...

Human Human Cells
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ...
TMPJ-00625 Serpin E1 Protein, Mouse, Recombinant (His)

Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi...

Mouse Human Cells
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
TMPY-05179 TFPI Protein, Human, Recombinant (His), Biotinylated

TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ...

Human HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is...
TMPY-05800 IKB beta/NFKBIB Protein, Human, Recombinant (GST)

NFKB inhibitor β,NFKB inhibitor beta,TRIP9...

Human E. coli
NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor pr...
TMPJ-00101 TIMP-2 Protein, Human, Recombinant (His)

Tissue Inhibitor of Metalloproteinases 2,TIMP2,CSC-...

Human Human Cells
Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and i...
TMPJ-00972 CDKN1B Protein, Human, Recombinant (His)

KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,C...

Human E. coli
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPY-00928 TFPI Protein, Mouse, Recombinant (His)

AW552122,A630013F22Rik,tissue factor pathway inhibitor

Mouse HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is...
TMPY-00163 SPINK2 Protein, Human, Recombinant (hFc)

serine peptidase inhibitor, Kazal type 2 (acrosin-t...

Human HEK293
Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas ...
TMPJ-01383 Serpin A10 Protein, Human, Recombinant (His)

PZI,Protein Z-Dependent Protease Inhibitor,Serpin A...

Human Human Cells
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis.
TMPY-05797 DKK1 Protein, Rat, Recombinant (His)

dickkopf WNT signaling pathway inhibitor 1

Rat HEK293
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori...
TMPJ-00931 Serpin A4 Protein, Human, Recombinant (His)

Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein

Human Human Cells
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,...
TMPJ-01069 Serpin A1e Protein, Mouse, Recombinant (His)

Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease

Mouse Human Cells
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ...
TMPY-03127 BAMBI Protein, Mouse, Recombinant (hFc)

2610003H06Rik,BMP and activin membrane-bound inhibitor

Mouse HEK293
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth f...
TMPJ-01064 Serpin G1 Protein, Mouse, Recombinant (His)

Serping1,Plasma protease C1 inhibitor,C1 Inh,C1 est...

Mouse Human Cells
SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later...
TMPY-02187 Semaphorin 5A Protein, Human, Recombinant (hFc)

SEMAF,serpin peptidase inhibitor, clade F,semF

Human HEK293
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 2 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse d...
TMPY-01175 DKK1 Protein, Rhesus, Recombinant (256 Asn/Gln, mFc)

dickkopf WNT signaling pathway inhibitor 1

Rhesus HEK293
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori...
TMPY-02981 ING5 Protein, Human, Recombinant (GST)

p28ING5,inhibitor of growth family, member 5

Human E. coli
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRP...
TMPY-02559 PAI-1 Protein, Rat, Recombinant (His)

serpin peptidase inhibitor, clade E (nexin, plasmin...

Rat HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 def...
TMPJ-00685 BAI3 Protein, Human, Recombinant (His)

BAI3,KIAA0550,Brain-Specific Angiogenesis Inhibitor...

Human Human Cells
Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein, which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids in size. It contains three distinct regions: an N-terminal extracellular domain (ECD) (aa25-883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type 1 repeat (aa296-...
TMPY-00397 ITIH3 Protein, Human, Recombinant (hFc)

H3P,SHAP,inter-α-trypsin inhibitor heavy chain 3,in...

Human HEK293
ITIH3 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 3) is a Protein Coding gene. This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. ITIH3 is involved in the stabilization of the extracellular matrix. A polymorphism (rs2535629) of ITIH3 showed the strongest association signal with susceptibility to psychiatric disorders in Caucasian populations. Common single nucleotide...
TMPJ-00502 Serpin G1 Protein, Human, Recombinant (His)

C1-Inhibiting Factor,Serpin G1,SERPING1,C1 Esterase Inhi...

Human Human Cells
As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein. It is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain ...
TMPJ-00452 Serpin A1a Protein, Mouse, Recombinant (His)

Alpha-1-antitrypsin 1-1, Alpha-1 protease inhibitor...

Mouse Human Cells
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
TMPY-00266 PEDF Protein, Rat, Recombinant (His)

serpin peptidase inhibitor, clade F,member 1

Rat HEK293
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-a...
TMPY-01456 BAMBI Protein, Human, Recombinant (His)

BMP and activin membrane-bound inhibitor,NMA

Human HEK293
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth f...
TMPY-04334 BAMBI Protein, Mouse, Recombinant (His)

BMP and activin membrane-bound inhibitor,2610003H06...

Mouse HEK293
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth f...
TMPY-01570 Semaphorin 5A Protein, Human, Recombinant (His)

serpin peptidase inhibitor, clade F,SEMAF,semF

Human HEK293
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 2 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse d...
TMPJ-00243 Serpin B6 Protein, Human, Recombinant (His)

CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytop...

Human E. coli
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se...
TMPJ-01253 Serpin A3N Protein, Mouse, Recombinant (His)

Serpina3n,Serine protease inhibitor A3N,Spi2,Serpin...

Mouse Human Cells
Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic ...
TMPJ-01309 PKI-Beta Protein, Human, Recombinant (His)

PRKACN2,PKI-beta,PKI-β,cAMP-Dependent Protein Kinase Inh...

Human E. coli
cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity; this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. It may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and...
TMPY-06377 DKK3 Protein, Human, Recombinant

REIC,dickkopf WNT signaling pathway inhibitor 3,RIG

Human HEK293
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its...
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重组蛋白

C1 inhibitor Protein, Rat, Recombinant (His)
TMPY-04815
synonym: serpin peptidase inhibitor, clade G (C1 inhibit...
Species: Rat
Source: HEK293
C1 inhibitor Protein, Human, Recombinant (His)
TMPY-01183
synonym: serpin peptidase inhibitor, clade G (C1 inhibit...
Species: Human
Source: HEK293
TFPI Protein, Human, Recombinant (His)
TMPY-01030
synonym: TFPI1,tissue factor pathway inhibitor (lipoprotein-...
Species: Human
Source: HEK293
DKK1 Protein, Rhesus, Recombinant (256 Asn/Gln, His)
TMPY-01174
synonym: dickkopf WNT signaling pathway inhibitor 1
Species: Rhesus
Source: HEK293
DKK3 Protein, Mouse, Recombinant (His)
TMPY-01121
synonym: dickkopf WNT signaling pathway inhibitor 3,C87148,A...
Species: Mouse
Source: HEK293
DKK1 Protein, Mouse, Recombinant (His)
TMPY-04811
synonym: dickkopf WNT signaling pathway inhibitor 1,mdkk-1
Species: Mouse
Source: HEK293
B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-06074
synonym: V-set domain containing T cell activation inhibitor...
Species: Cynomolgus,Rhesus
Source: HEK293
DKK1 Protein, Human, Recombinant (His)
TMPY-00775
synonym: dickkopf WNT signaling pathway inhibitor 1,SK,DKK-1
Species: Human
Source: HEK293
SPINK4 Protein, Mouse, Recombinant (hFc)
TMPY-02731
synonym: MPGC60,serine peptidase inhibitor, Kazal type 4,RP2...
Species: Mouse
Source: HEK293
PAI-1 Protein, Human, Recombinant (His)
TMPY-01474
synonym: PAI,SERPINE1,PAI-1,serpin peptidase inhibitor, clad...
Species: Human
Source: HEK293
B7-H4 Protein, Mouse, Recombinant (His)
TMPY-05322
synonym: BC032925,B7h4,B7x,V-set domain containing T cell activation ...
Species: Mouse
Source: HEK293
SerpinA1 Protein, Human, Recombinant (His)
TMPY-00915
synonym: PRO2275,SerpinA1,serpin peptidase inhibitor, clade ...
Species: Human
Source: HEK293
Antithrombin III Protein, Human, Recombinant (His)
TMPY-00916
synonym: AT3D,THPH7,ATIII,AT3,Serpin C1,MGC22579,serpin peptidase
Species: Human
Source: HEK293
TIMP-2 Protein, Mouse, Recombinant (His)
TMPJ-00916
synonym: metalloproteinase inhibitor 2,Tissue inhibitor<...
Species: Mouse
Source: Human Cells
TL1A Protein, Mouse, Recombinant
TMPJ-00603
synonym: TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V...
Species: Mouse
Source: E. coli
B7-H4 Protein, Human, Recombinant (His)
TMPY-03524
synonym: PRO1291,B7X,B7H4,B7-H4,VCTN1,B7S1,B7h.5,V-set domain contain...
Species: Human
Source: HEK293
TIMP-1 Protein, Rat, Recombinant
TMPY-02912
synonym: TIMP metallopeptidase inhibitor 1
Species: Rat
Source: HEK293
PTGFRN Protein, Cynomolgus, Recombinant (His)
TMPY-03876
synonym: prostaglandin F2 receptor inhibitor
Species: Cynomolgus
Source: HEK293
Serpin A5 Protein, Human, Recombinant (His)
TMPJ-00490
synonym: Plasminogen Activator Inhibitor 3,Acrosomal Serine ...
Species: Human
Source: Human Cells
TIMP-4 Protein, Human, Recombinant (His)
TMPJ-01289
synonym: TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue <...
Species: Human
Source: Human Cells
SPINK1 Protein, Human, Recombinant (His)
TMPJ-00733
synonym: PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Se...
Species: Human
Source: Human Cells
Serpin E1 Protein, Mouse, Recombinant (His)
TMPJ-00625
synonym: Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi...
Species: Mouse
Source: Human Cells
TFPI Protein, Human, Recombinant (His), Biotinylated
TMPY-05179
synonym: TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ...
Species: Human
Source: HEK293
IKB beta/NFKBIB Protein, Human, Recombinant (GST)
TMPY-05800
synonym: NFKB inhibitor β,NFKB inhibitor beta,TRIP9...
Species: Human
Source: E. coli
TIMP-2 Protein, Human, Recombinant (His)
TMPJ-00101
synonym: Tissue Inhibitor of Metalloproteinases 2,TIMP2,CSC-...
Species: Human
Source: Human Cells
CDKN1B Protein, Human, Recombinant (His)
TMPJ-00972
synonym: KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,C...
Species: Human
Source: E. coli
TFPI Protein, Mouse, Recombinant (His)
TMPY-00928
synonym: AW552122,A630013F22Rik,tissue factor pathway inhibitor
Species: Mouse
Source: HEK293
SPINK2 Protein, Human, Recombinant (hFc)
TMPY-00163
synonym: serine peptidase inhibitor, Kazal type 2 (acrosin-t...
Species: Human
Source: HEK293
Serpin A10 Protein, Human, Recombinant (His)
TMPJ-01383
synonym: PZI,Protein Z-Dependent Protease Inhibitor,Serpin A...
Species: Human
Source: Human Cells
DKK1 Protein, Rat, Recombinant (His)
TMPY-05797
synonym: dickkopf WNT signaling pathway inhibitor 1
Species: Rat
Source: HEK293
Serpin A4 Protein, Human, Recombinant (His)
TMPJ-00931
synonym: Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein
Species: Human
Source: Human Cells
Serpin A1e Protein, Mouse, Recombinant (His)
TMPJ-01069
synonym: Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease
Species: Mouse
Source: Human Cells
BAMBI Protein, Mouse, Recombinant (hFc)
TMPY-03127
synonym: 2610003H06Rik,BMP and activin membrane-bound inhibitor
Species: Mouse
Source: HEK293
Serpin G1 Protein, Mouse, Recombinant (His)
TMPJ-01064
synonym: Serping1,Plasma protease C1 inhibitor,C1 Inh,C1 est...
Species: Mouse
Source: Human Cells
Semaphorin 5A Protein, Human, Recombinant (hFc)
TMPY-02187
synonym: SEMAF,serpin peptidase inhibitor, clade F,semF
Species: Human
Source: HEK293
DKK1 Protein, Rhesus, Recombinant (256 Asn/Gln, mFc)
TMPY-01175
synonym: dickkopf WNT signaling pathway inhibitor 1
Species: Rhesus
Source: HEK293
ING5 Protein, Human, Recombinant (GST)
TMPY-02981
synonym: p28ING5,inhibitor of growth family, member 5
Species: Human
Source: E. coli
PAI-1 Protein, Rat, Recombinant (His)
TMPY-02559
synonym: serpin peptidase inhibitor, clade E (nexin, plasmin...
Species: Rat
Source: HEK293
BAI3 Protein, Human, Recombinant (His)
TMPJ-00685
synonym: BAI3,KIAA0550,Brain-Specific Angiogenesis Inhibitor...
Species: Human
Source: Human Cells
ITIH3 Protein, Human, Recombinant (hFc)
TMPY-00397
synonym: H3P,SHAP,inter-α-trypsin inhibitor heavy chain 3,in...
Species: Human
Source: HEK293
Serpin G1 Protein, Human, Recombinant (His)
TMPJ-00502
synonym: C1-Inhibiting Factor,Serpin G1,SERPING1,C1 Esterase Inhi...
Species: Human
Source: Human Cells
Serpin A1a Protein, Mouse, Recombinant (His)
TMPJ-00452
synonym: Alpha-1-antitrypsin 1-1, Alpha-1 protease inhibitor...
Species: Mouse
Source: Human Cells
PEDF Protein, Rat, Recombinant (His)
TMPY-00266
synonym: serpin peptidase inhibitor, clade F,member 1
Species: Rat
Source: HEK293
BAMBI Protein, Human, Recombinant (His)
TMPY-01456
synonym: BMP and activin membrane-bound inhibitor,NMA
Species: Human
Source: HEK293
BAMBI Protein, Mouse, Recombinant (His)
TMPY-04334
synonym: BMP and activin membrane-bound inhibitor,2610003H06...
Species: Mouse
Source: HEK293
Semaphorin 5A Protein, Human, Recombinant (His)
TMPY-01570
synonym: serpin peptidase inhibitor, clade F,SEMAF,semF
Species: Human
Source: HEK293
Serpin B6 Protein, Human, Recombinant (His)
TMPJ-00243
synonym: CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytop...
Species: Human
Source: E. coli
Serpin A3N Protein, Mouse, Recombinant (His)
TMPJ-01253
synonym: Serpina3n,Serine protease inhibitor A3N,Spi2,Serpin...
Species: Mouse
Source: Human Cells
PKI-Beta Protein, Human, Recombinant (His)
TMPJ-01309
synonym: PRKACN2,PKI-beta,PKI-β,cAMP-Dependent Protein Kinase Inh...
Species: Human
Source: E. coli
DKK3 Protein, Human, Recombinant
TMPY-06377
synonym: REIC,dickkopf WNT signaling pathway inhibitor 3,RIG
Species: Human
Source: HEK293
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