10000
1000+
17
94
434
Cat. No. | Product Name | ||
---|---|---|---|
L2000 | 抑制剂库 | 8418 compounds | |
8418 个小分子抑制剂的独特集合,主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选; | |||
L9100 | 磷酸酶抑制剂化合物库 | 80 compounds | |
80 种已知活性的磷酸酶抑制剂的集合,可用于化合物筛选、化学基因组学、药理分析等方面; | |||
L1600 | 激酶抑制剂库 | 2230 compounds | |
2230 种激酶抑制剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9400 | PPI抑制剂库 | 490 compounds | |
490 种已知活性的 PPI 相关的抑制剂,可用于高通量、高内涵筛选; | |||
L1400 | MAPK 抑制剂库 | 367 compounds | |
367 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L1100 | 蛋白酶抑制剂库 | 344 compounds | |
344 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选; | |||
L9410 | 共价抑制剂库 | 1949 compounds | |
1949 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L3600 | 细胞因子抑制剂库 | 613 compounds | |
613 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体; | |||
L2200 | 酪氨酸激酶分子库 | 1033 compounds | |
1033 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2300 | 离子通道库 | 946 compounds | |
946 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选; | |||
L1610 | FDA 上市激酶抑制剂库 | 280 compounds | |
TargetMol FDA 上市激酶库包含280 个具有明确激酶抑制活性的上市药物 | |||
L2010 | 高选择性抑制剂库 | 580 compounds | |
xunm种具有高选择性的抑制剂集合 | |||
L1510 | 核受体化合物库 | 546 compounds | |
546 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L8000 | 干细胞分化化合物库 | 1213 compounds | |
1213 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选; | |||
L7000 | 活性脂质化合物库 | 385 compounds | |
385 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L7110 | 抗高血压化合物库 | 719 compounds | |
719 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10876 |
CPA inhibitor
Carboxypeptidase inhibitor |
Carboxypeptidase | Proteases/Proteasome |
CPA inhibitor (Carboxypeptidase inhibitor) 是一种有效的羧肽酶 A (CPA) 抑制剂,Ki 值为 0.32 μM。 | |||
T5451 |
Eph inhibitor 2
Ehp-inhibitor-1 |
Ephrin Receptor | Tyrosine Kinase/Adaptors |
Eph inhibitor 2 是一种 Eph 家族酪氨酸激酶抑制剂。 | |||
T1804 |
HPGDS inhibitor 1
HPGDS-inhibitor-1 |
PGE Synthase | Immunology/Inflammation |
HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂,在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM,但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。 | |||
T4338 |
USP7/USP47 inhibitor
USP7/47 inhibitor-1 |
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
USP7/USP47 inhibitor (USP7/47 inhibitor-1) 是一种选择性泛素特异性蛋白酶 7/47 抑制剂,EC50值分别为 0.42 μM 和 1.0 μM。 | |||
T5524 |
Aurora kinase inhibitor-3
Aurora Kinase Inhibitor III |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) 是一种有效的,选择性 Aurora A 激酶抑制剂,IC50为 42 nM。 | |||
T2350 |
MALT1 inhibitor MI-2
MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor) |
MALT | Immunology/Inflammation |
MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM),对动物无毒性。它能够直接与 MALT1 结合,不可逆地抑制蛋白酶功能,并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。 | |||
T8766 |
GOT1 inhibitor-1
GOT1 inhibitor 2c |
Others | Others |
GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM),是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。 | |||
T5817 |
PKC-theta inhibitor hcl
PKC-theta inhibitor |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
PKC-theta inhibitor hcl 是一种选择性 PKC-θ 抑制剂 (IC50:12 nM)。 | |||
T3189 |
B7/CD28 interaction inhibitor 1
CTLA-4 inhibitor |
Others | Others |
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。 | |||
T2074 |
Raf inhibitor 1
B-Raf inhibitor 1 |
Raf | MAPK |
Raf inhibitor 1 (B-Raf inhibitor 1)是Raf 激酶抑制剂,对B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。 | |||
T38683 |
SCD1 inhibitor-3
SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a |
Dehydrogenase | Metabolism |
SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物,可以抑制SCD1,且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常,以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。 | |||
T3593 |
Src Inhibitor 1
Src Kinase Inhibitor 1,Src-l1 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Src Inhibitor 1 (Src Kinase Inhibitor 1) 是一种选择性的、高效的、ATP-竞争性的双位点 Src 酪氨酸激酶抑制剂,能够抑制 Src (IC50:44 nM) 和 Lck (IC50:88 nM)。 | |||
T3042 |
JAK2 Inhibitor V
JAK2 Inhibitor V Z3,Z3 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2 Inhibitor V (JAK2 Inhibitor V Z3) 是一种新型的 Jak2 特异性抑制剂,以剂量依赖性方式抑制 Jak2-V617F 和 Jak2-WT 自磷酸化。 | |||
T6335 |
Tie2 kinase inhibitor 1
Tie2 kinase inhibitor |
Tie-2 | Tyrosine Kinase/Adaptors |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。 | |||
T4191 |
Multi-kinase inhibitor 1
Multi-kinase inhibitor I |
Others; Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与c-Kit,PDGF-R,Bcr-abl 活性相关的疾病。 | |||
T4391 |
Syk Inhibitor II dihydrochloride
Syk Inhibitor II (hydrochloride) |
Others; Tyrosine Kinases; Syk; PKC; BTK | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors |
Syk Inhibitor II (hydrochloride) 是一种非受体酪氨酸激酶,磷酸化后,它与 FcRγ 链的基于免疫受体酪氨酸的激活基序结合,并介导与血小板功能和炎症相关的下游信号传导。 Syk inhibitor II 是一种可渗透细胞的嘧啶-甲酰胺化合物,以 ATP 竞争性方式选择性和可逆地阻断 Syk (IC50 = 41 nM)。它对 PKCε、PKCβII、ZAP-70、Btk 和 Itk 的效力要低得多(IC50s 分别为5.1、11、11.2、15.5 和 22.6 μM)。 | |||
T10678 |
Carboxypeptidase G2 (CPG2) Inhibitor
CPG2 Inhibitor,Carboxypeptidase G2 Inhibitor |
Carboxypeptidase | Proteases/Proteasome |
Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) 是新型的羧肽酶 G2(CPG2)抑制剂,显示出抗癌活性。 | |||
T2457 |
IRAK-1-4 Inhibitor I
IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor |
IRAK | Immunology/Inflammation; NF-κB |
IRAK-1-4 Inhibitor I 是一种IRAK1/4双重抑制剂,其IC50分别为 0.2 μM 和 0.3 μM。 | |||
T67767 |
HIF-1 inhibitor-4
HIF-1 inhibitor-4 |
HIF | Angiogenesis; Chromatin/Epigenetic |
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) 是一种 HIF-1 抑制剂 (IC50: 560 nM)。HIF-1 inhibitor-4 减少 HIF-1α 蛋白水平,但不影响 mRNA 水平。 | |||
T24141 |
HIV-1 Inhibitor 18A
HIV-1 Inhibitor-18A |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) 特异性抑制多种 HIV-1 分离株的进入。 | |||
T4167 |
Raf inhibitor 1 dihydrochloride
B-Raf inhibitor 1 dihydrochloride |
Raf | MAPK |
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂,对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。 | |||
T35827L |
PKCε Inhibitor Peptide acetate
PKCε Inhibitor Peptide acetate(182683-50-7 Free base) |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
PKCε Inhibitor Peptide acetate 是一种特异性 PKCε 抑制剂,含有其特定受体活化 C 激酶 (RACK) 的位点。 PKCε Inhibitor Peptide acetate 抑制 PKCε 的转运,但不抑制 αPKC,βPKC 和 δPKC 的转运。 | |||
T4491 |
LMPTP INHIBITOR 1 hydrochloride
LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) |
Phosphatase | Metabolism |
LMPTP INHIBITOR 1 hydrochloride 是一种高选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂。LMPTP INHIBITOR 1 (hydrochloride) 能够抑制 LMPTP-A 的活性,IC50值为 0.8 μM。 | |||
T9040 |
Aurora kinase inhibitor-2
IUN-70219,Aurora Kinase Inhibitor II |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Aurora kinase inhibitor-2 (IUN-70219) 是一种可渗透细胞的苯胺喹唑啉,可抑制极光激酶的活性,对Aurora A 和Aurora B 的IC50分别为 390 nM 和 240 nM。 | |||
T21954 |
EGFR/ErbB-2/ErbB-4 inhibitor-2
EGFR/ErbB2 Inhibitor |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) 是EGFR 和ErbB 的抑制剂,对EGFR、ErbB2 和 ErbB4 的IC50分别为 0.017、0.08 和 1.91 μM。 | |||
TP2008L |
Lyn peptide inhibitor acetate
Lyn peptide inhibitor acetate(222018-18-0 free base) |
IL Receptor | Immunology/Inflammation |
Lyn peptide inhibitor acetate(222018-18-0 free base) 是一种有效的细胞渗透性 Lyn 偶联 IL-5 受体信号通路抑制剂,同时保持其他信号完整。它阻断 Lyn 活化并抑制 Lyn 酪氨酸激酶与 IL-3/GM-CSF/IL-5 受体的 βc 亚基的结合。它可用于哮喘、过敏和其他嗜酸性粒细胞疾病的研究。 | |||
T17157 |
TRAF-STOP inhibitor 6877002
CD40-TRAF6 inhibitor |
NF-κB | NF-κB |
TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂,可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化,减少白细胞募集和巨噬细胞的活化,减少动脉粥样硬化斑块中的巨噬细胞增殖。 | |||
T9178 |
(E/Z)-GSK-3β inhibitor 1
GSK-3β inhibitor 1 |
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
(E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。它是一种糖原合成酶激酶 3β (GSK-3β)的抑制剂,可其对 GSK-3β 的 IC50=4.9 nM,用于糖尿病的研究。 | |||
T10927 |
Cyt-PTPε Inhibitor-1
Cyt-PTP|A Inhibitor-1 |
Phosphatase; Src | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。 | |||
T36933 |
Cdk2 Inhibitor II
Cdk2 Inhibitor II,CDK2-IN-3 |
CDK | Cell Cycle/Checkpoint |
Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂,50 为 60 nM。 | |||
T10865L |
Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride(915365-57-0 Free base) |
TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 hydrochloride 是肿瘤进展位点 2 激酶 (IC50 = 28 nM) 的抑制剂,可抑制人全血中 TNF-α 的产生 (IC50 = 5.7 nM)。 | |||
TP1523 |
PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA |
PKA | Tyrosine Kinase/Adaptors |
PKG inhibitor peptide TFA (82801-73-8 free base) 是 ATP 竞争性 cGMP 依赖性蛋白激酶 (PKG) 的抑制剂。 | |||
T22081 |
FBPase-1 inhibitor-1
Fructose 1,6-bisphosphatase-1 Inhibitor |
Others | Others |
FBPase-1 inhibitor-1 (Fructose 1,6-bisphosphatase-1 Inhibitor) 是一种fructose-1,6-bisphosphatase (FBPase-1)的变构抑制剂。 | |||
T22136 |
PRL-3 Inhibitor I
PRL-3 Inhibitor,BR-1 |
Phosphatase; Others | Metabolism; Others |
PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂,IC50=0.9 μM。它在细胞检测中显示降低侵袭性。 | |||
T10599 | BRAF inhibitor | Raf | MAPK |
BRAF inhibitor 是B-Raf 抑制剂。 | |||
T2649 |
Menin-MLL inhibitor MI-2
Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2 |
Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用,IC50为 446±28 nM。 | |||
TP1015 |
NFAT Inhibitor
VIVIT peptide |
Others | Others |
NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂,能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。 | |||
TP1890L1 |
MLCK inhibitor peptide 18 acetate
MLCK inhibitor peptide 18 acetate(224579-74-2 free base) |
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
MLCK inhibitor peptide 18 acetate(224579-74-2 free base) 是肌球蛋白轻链激酶的选择性竞争性抑制剂 (IC50 = 50 nM)。显示出比 CaM 激酶 II 高 4000 倍的选择性,并且不抑制 PKA。细胞可渗透。 | |||
T11184 |
EML4-ALK kinase inhibitor 1
EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1 |
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) 是有效的、具有口服活性的类棘皮细胞微管相关蛋白4-间变性淋巴瘤激酶 (EML4-ALK) 的抑制剂,其 IC50 值为 1 nM。 | |||
T7541 |
PTP inhibitor 1
PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮 |
Phosphatase | Metabolism |
PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成作用。 | |||
T60108 |
PDGFR Tyrosine Kinase Inhibitor III
PDGF Receptor Tyrosine Kinase Inhibitor III |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III)是一种多激酶抑制剂,可抑制 PDGFR、EGFR、FGFR、PKA 和 PKC 等。PDGFR Tyrosine Kinase Inhibitor III 可用于肌萎缩侧索硬化症的研究。 | |||
T12502 |
PLpro inhibitor
5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺 |
SARS-CoV | Microbiology/Virology |
PLpro inhibitor 是一种木瓜蛋白酶抑制剂,IC50为 2.6 µM,能抑制 SARS-CoV-2 PLpro。 | |||
T2159 | CaMKP Inhibitor | CaMK | Neuroscience |
CaMKP Inhibitor 可以抑制 CaMKP。 | |||
T10276L |
AKT Kinase Inhibitor HCl
AKT Kinase Inhibitor HCl(842148-40-7 Free base) |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
AKT Kinase Inhibitor HCl 是一种 Akt 抑制剂,具有抗肿瘤活性。 | |||
T60119 |
SOD1-Derlin-1 inhibitor-1
SOD1-Derlin-1 Inhibitor 56-20 |
Others | Others |
SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) 是 SOD1-Derlin-1相互作用的抑制剂。SOD1-Derlin-1 inhibitor-1 抑制 SOD1G93A-Derlin-1 复合物,IC50值为 7.11 μM。SOD1-Derlin-1 inhibitor-1 可用于肌萎缩性侧索硬化症的研究。 | |||
T5452 | Ehp-inhibitor-2 | Ephrin Receptor | Tyrosine Kinase/Adaptors |
Ehp-inhibitor-2 是一种靶向 Eph 受体的 Eph 家族酪氨酸激酶抑制剂。 | |||
T36802L |
Bisubstrate Inhibitor 78 HCl
Bisubstrate Inhibitor 78 HCl(2368247-39-4 Free base) |
Others | Others |
Bisubstrate Inhibitor 78 HCl 是一种 NNMT 抑制剂(IC50 = 1.41 μM),具有潜在的抗癌活性,在 100μM 时抑制HSC-2口腔癌细胞增殖。 | |||
T21521L |
Papain Inhibitor acetate
乙氨酸-乙氨酸-酪氨酸-精氨酸,GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate (70195-20-9 free base) |
Others | Others |
Papain Inhibitor acetate (Gly-Gly-Tyr-Arg) 是木瓜蛋白酶的亲和配体。 | |||
T10463L |
Bax inhibitor peptide V5 acetate
Bax inhibitor peptide V5 acetate(579492-81-2 free base) |
Apoptosis | Apoptosis |
Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) 是一种 Bax 介导的细胞凋亡抑制剂,用于癌症治疗。 | |||
T13224 |
Tubulin inhibitor 6
iHAP1 |
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂,抑制微管蛋白聚合,IC50为 0.87 μM。它抑制多种癌细胞系,抑制 K562 细胞生长,IC50为 840 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3384 |
Wedelolactone
蟛蜞菊内酯,IKK Inhibitor II |
Apoptosis; NF-κB; Lipoxygenase; Caspase | Apoptosis; Metabolism; NF-κB; Proteases/Proteasome |
Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物,通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录,具有抗癌,抗炎和抗氧化活性。 | |||
TJS0851 | Plantagoside | Others | Others |
Plantagoside 是α-mannosidase 的非竞争性特异性抑制剂(IC50:5 μM),分离自Plantago asiatica 种子中。 | |||
TN1829 | Kakkalide | Dehydrogenase | Metabolism |
Kakkalide 是提取自葛根花中的一种异黄酮。它可以抑制活性氧相关炎症,并改善内皮细胞胰岛素抵抗作用。 | |||
T6S2252 | Sweroside | Others | Others |
Sweroside 是分离自Lonicera japonica 中,具有细胞保护、抗骨质疏松和保护肝脏活性。 | |||
T3S2019 | Lathyrol | Others | Others |
Lathyrol 是一种具有抗癌功能的天然产物。 | |||
T3S1729 | Dihydrolycorine | Others | Others |
Dihydrolycorine 是分离自Lycoris radiate 草药中,是一种真核细胞中蛋白质合成的抑制剂。 | |||
T8169 | Decursinol | Others | Others |
Decursinol 是一种分离自Angelica gigas 的根中的、口服具有活性的抗伤害药物。它具有抗肿瘤和抗转移作用。 | |||
TN1833 | Karacoline | NF-κB | NF-κB |
Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱,通过 NF-κB 信号通路,抑制椎间盘退变中细胞外基质的降解。 | |||
TN6712 | yibeissine | Others | Others |
Yibeissine 是一种甾体生物碱,分离自贝母球茎中。 | |||
T3S1850 | Bayogenin | Others | Others |
Bayogenin 是紫花苜蓿皂苷,一定程度上能够抑制糖原磷酸化酶的活性。 | |||
T5789 | XYLOTRIOSE | Others | Others |
Xylotriose 是双歧杆菌促生因子,是天然的低聚木糖。 | |||
T8212 | Dichotomitin | Others | Others |
Dichotomitin 是一种提取自Belamcanda chinensis 根茎中的异黄酮。 | |||
TN1111 | Arnidiol | Immunology/Inflammation related | Immunology/Inflammation |
Arnidiol 是一种五环三萜烯,从Barleria Longiflora LinnF. 中提取得到。 | |||
TQ0096 | Scabertopin | Others | Others |
Scabertopin 是一种从地胆草中分离得到倍半萜内酯,具有抗癌和抑菌活性。 | |||
T7032 | Eupatorin | Others; P450 | Metabolism; Others |
Eupatorin 是天然存在的黄酮,可捕获 G2-M 细胞周期,激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解,促使凋亡细胞死亡。 | |||
T8203 | Gentianose | Others | Others |
Gentianose 是一种碳水化合储备物,来源于多年生黄龙胆贮藏根中。 | |||
TN2197 | Secoisolariciresinol | TNF | Apoptosis |
Secoisolariciresinol 是一种属于苯丙素类的木脂素。 | |||
TN1002 | Blumeatin | ROS | Immunology/Inflammation |
Blumeatin 是从Blumea balsamiferaDC 中分离得到,对 CCl4 和硫代乙酰胺 (TAA) 所致的肝损伤表现出保护活性。 | |||
T13350 | Wushanicaritin | Others | Others |
Wushanicaritin 在 DPPH 自由基清除活性测试中显示出显著的抗氧化活性 ,其IC50值为35.3 μM,具有抗肿瘤作用和抗炎活性。 | |||
T16943 | Stigmastanol | Endogenous Metabolite | Metabolism |
Stigmastanol 是分离自Hypericum riparium 的 6-氨基衍生物。Hypericum riparium 是属于杜仲科的药用植物。 | |||
Fr13711 | Tropinone | Others | Others |
Tropinone 是一种可用作合成 Atropine 中间体的生物碱。 | |||
T14961 |
Chrysene
䓛,屈 |
Others | Others |
Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
T13693 | Fibrin | Others | Others |
Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding. | |||
T19231 | Cellulase | Others | Others |
Cellulase 是一种能够催化纤维素和其他碳水化合物水解的酶。 | |||
TN1640 | Fabiatrin | Others | Others |
Fabiatrin 是从 Przewalskia tangutica 的正丁醇提取物中分离和鉴定的天然产物。 | |||
T6S0234 | Toosendanin | Others | Others |
Toosendanin 是一种从杜鹃花果实皮中提取的三萜,具有杀虫和抗炎活性,可用于研究缓解疼痛。 | |||
T5S0661 | Koumine | Others | Others |
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。 | |||
T3S2027 | Rubusoside | Others | Others |
Rubusoside 是天然的增溶剂及甜味剂,具有良好的抗血管新生和抗过敏药的特性。 | |||
TN2058 | Persicogenin | Anti-infection | Microbiology/Virology |
Persicogenin 是分离自 Rhus retinorrhoea 中,具有抗癌作用。 | |||
T3A2414 | Manninotriose | Others | Others |
Manninotriose 是小野芝麻主要的碳水化合物(Lamium 象草,唇形科)。 | |||
TN1081 | Hirsuteine | Dopamine Receptor | GPCR/G Protein; Neuroscience |
Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物,非竞争性地拮抗烟碱介导的多巴胺释放。 | |||
T8161 | Vicine | Others | Others |
Vicine 是一种主要存在于蚕豆中的生物碱糖苷,对人体有毒,可引起溶血性贫血。 | |||
TN1816 | Kadsurin | Antioxidant | oxidation-reduction |
Kadsurin 是一种提取自异形南五味子茎中的天然产物,能够显著降低小鼠肝脏中CCL4诱导的脂质过氧化产物(例如TBA-RS、共轭二烯和荧光产物)。 | |||
T3928 | Neoliquiritin | Others | Others |
Neoliquiritin 是从甘草 Glycyrrhiza uralensis 分离得到,具有抗炎作用。它可能具有细胞毒性和肿瘤特异性。 | |||
T6S1657 | Paeonolide | Others | Others |
Paeonolide 是一种广泛存在于 Paeonia 属植物根中的植物糖苷,含有一个非还原性末端 α-1-阿拉伯吡喃糖苷。 | |||
T3817 | Darutigenol | Others | Others |
Darutigenol 是一种戊二萜,从Siegesbecikia orientalis L.中分离得到。 | |||
T7033 | Rosmanol | Antioxidant; COX | Immunology/Inflammation; Neuroscience; oxidation-reduction |
Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达,抑制低密度脂蛋白的氧化,并具有抗炎作用。 | |||
T6S1049 | Wilforine | ATPase | Membrane transporter/Ion channel |
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。 | |||
T4953 | Neotuberostemonine | NOS | Immunology/Inflammation |
Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱,能够阻碍巨噬细胞的募集和活化,从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。 | |||
T5747 | ISOBERGAPTEN | Others | Others |
Isobergapten 是一种化感抑制剂,分离自Hevacleum laciniatum 种子。 | |||
TN3548 | Bulleyanin | Others | Others |
Bulleyanin 是从 isodon species (Labiatae) 中分离出来的一种物质。 | |||
T39049 | Yubeinine | Others | Others |
Yubeinine 是一种生物碱类天然产物,可以起到气管松弛作用。 | |||
TN1785 | Isomagnolone | Others | Others |
Isomagnolone 是一种分离自八角茴香中的天然产物,具有抗炎作用。 | |||
TN1455 | Bryodulcosigenin | Immunology/Inflammation related | Immunology/Inflammation |
Bryodulcosigenin 是一种 Bryoniadioica 根的提取物,具有抗炎活性。 | |||
T8195 | Lotusine | Others | Others |
Lotusine 是一种提取自Nelumbo nucifera Gaertn 的绿色种胚中的纯生物碱。它能够作用于心肌中动作电位及心脏浦肯野纤维缓慢内向电流。 | |||
TN1028 | Militarine | Others | Others |
Militarine 是一种糖苷化合物,分离自 Bletilla striata,能够抑制植物生长。 | |||
T3S0693 | Blinin | Others | Others |
Blinin 是一种二萜,分离自植物 Conyza blinii 中。 | |||
T8194 | Isoflavone | Antioxidant | oxidation-reduction |
Isoflavone 是大豆植物雌激素和生物活性成分,存在于大豆、青豆、花生、鹰嘴豆和苜蓿等几种重要的豆类作物中。 | |||
TN1065 | Hirsutine | Apoptosis | Apoptosis |
Hirsutine 是一种来自钩藤的吲哚生物碱,可诱导细胞凋亡,是一种登革热病毒抑制剂,且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。 | |||
T5813 | BYAKANGELICIN | Reductase | Endocrinology/Hormones; Metabolism |
Byakangelicin 是发现于当归根中的一种活性化合物,可作为调节剂,改善各种活性化合物 (Umb,Cur 和 Dox) 的脑积累,增强研究效果。它提高所有PXR 靶基因 (如MDR1) 的表达,并广泛的诱导药物-药物相互作用。它可抑制性激素的作用,可能会增加内源激素的分解代谢。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04815 |
C1 inhibitor Protein, Rat, Recombinant (His)
serpin peptidase inhibitor, clade G (C1 inhibit... |
Rat | HEK293 |
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides ... | |||
TMPY-01183 |
C1 inhibitor Protein, Human, Recombinant (His)
serpin peptidase inhibitor, clade G (C1 inhibit... |
Human | HEK293 |
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides ... | |||
TMPY-01030 |
TFPI Protein, Human, Recombinant (His)
TFPI1,tissue factor pathway inhibitor (lipoprotein-... |
Human | HEK293 |
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... | |||
TMPY-01174 |
DKK1 Protein, Rhesus, Recombinant (N256Q, His)
dickkopf WNT signaling pathway inhibitor 1 |
Rhesus | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... | |||
TMPY-01121 |
DKK3 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 3,C87148,A... |
Mouse | HEK293 |
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its... | |||
TMPY-04811 |
DKK1 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,mdkk-1 |
Mouse | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... | |||
TMPY-00775 |
DKK1 Protein, Human, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,SK,DKK-1 |
Human | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... | |||
TMPY-02731 |
SPINK4 Protein, Mouse, Recombinant (hFc)
MPGC60,serine peptidase inhibitor, Kazal type 4,RP2... |
Mouse | HEK293 |
Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activit... | |||
TMPY-06074 |
B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)
V-set domain containing T cell activation inhibitor... |
Cynomolgus,Rhesus | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i... | |||
TMPY-01474 |
PAI-1 Protein, Human, Recombinant (His)
PAI,SERPINE1,PAI-1,serpin peptidase inhibitor, clad... |
Human | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 def... | |||
TMPY-05322 |
B7-H4 Protein, Mouse, Recombinant (His)
BC032925,B7h4,B7x,V-set domain containing T cell activation ... |
Mouse | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i... | |||
TMPY-00915 |
Serpin A1 Protein, Human, Recombinant (His)
PRO2275,SerpinA1,serpin peptidase inhibitor, clade ... |
Human | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within li... | |||
TMPY-00916 |
Antithrombin III Protein, Human, Recombinant (His)
AT3D,THPH7,ATIII,AT3,Serpin C1,MGC22579,serpin peptidase |
Human | HEK293 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagula... | |||
TMPJ-00603 |
TL1A Protein, Mouse, Recombinant
TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V... |
Mouse | E. coli |
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ... | |||
TMPJ-00916 |
TIMP-2 Protein, Mouse, Recombinant (His)
metalloproteinase inhibitor 2,Tissue inhibitor<... |
Mouse | Human Cells |
Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi... | |||
TMPY-03524 |
B7-H4 Protein, Human, Recombinant (His)
PRO1291,B7X,B7H4,B7-H4,VCTN1,B7S1,B7h.5,V-set domain contain... |
Human | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by i... | |||
TMPH-00554 | Trypsin inhibitor DE-3 Protein, Erythrina caffra, Recombinant (His) | Erythrina caffra | Yeast |
Part of the tripartite complex that is required for the CDT activity. CdtC, along with CdtA, probably forms a heterodimeric subunit required for the delivery of CdtB. | |||
TMPY-02912 |
TIMP-1 Protein, Rat, Recombinant
TIMP metallopeptidase inhibitor 1 |
Rat | HEK293 |
TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly ... | |||
TMPY-03876 |
PTGFRN Protein, Cynomolgus, Recombinant (His)
prostaglandin F2 receptor inhibitor |
Cynomolgus | HEK293 |
EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT. EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. EWI-F expression positively correlates with the metastatic status of hLT, and that the upregulation of EWI-F expression could be one of the mechanisms underlying the loss of CD9 in solid tumours. | |||
TMPJ-00490 |
Serpin A5 Protein, Human, Recombinant (His)
Plasminogen Activator Inhibitor 3,Acrosomal Serine ... |
Human | Human Cells |
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o... | |||
TMPJ-01289 |
TIMP-4 Protein, Human, Recombinant (His)
TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue <... |
Human | Human Cells |
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9. | |||
TMPY-05179 |
TFPI Protein, Human, Recombinant (His), Biotinylated
TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ... |
Human | HEK293 |
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... | |||
TMPJ-00733 |
SPINK1 Protein, Human, Recombinant (His)
PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Se... |
Human | Human Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ... | |||
TMPJ-00625 |
Serpin E1 Protein, Mouse, Recombinant (His)
Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi... |
Mouse | Human Cells |
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. | |||
TMPY-05800 |
IKB beta/NFKBIB Protein, Human, Recombinant (GST)
NFKB inhibitor β,NFKB inhibitor beta,TRIP9... |
Human | E. coli |
NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor pr... | |||
TMPY-00163 |
SPINK2 Protein, Human, Recombinant (hFc)
serine peptidase inhibitor, Kazal type 2 (acrosin-t... |
Human | HEK293 |
Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas ... | |||
TMPJ-00101 |
TIMP-2 Protein, Human, Recombinant (His)
Tissue Inhibitor of Metalloproteinases 2,TIMP2,CSC-... |
Human | Human Cells |
Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and i... | |||
TMPJ-00972 |
CDKN1B Protein, Human, Recombinant (His)
KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,C... |
Human | E. coli |
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ... | |||
TMPY-00928 |
TFPI Protein, Mouse, Recombinant (His)
AW552122,A630013F22Rik,tissue factor pathway inhibitor |
Mouse | HEK293 |
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is... | |||
TMPJ-01383 |
Serpin A10 Protein, Human, Recombinant (His)
PZI,Protein Z-Dependent Protease Inhibitor,Serpin A... |
Human | Human Cells |
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis. | |||
TMPY-05797 |
DKK1 Protein, Rat, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1 |
Rat | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... | |||
TMPJ-00931 |
Serpin A4 Protein, Human, Recombinant (His)
Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein |
Human | Human Cells |
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,... | |||
TMPJ-01069 |
Serpin A1e Protein, Mouse, Recombinant (His)
Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease |
Mouse | Human Cells |
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ... | |||
TMPJ-01064 |
Serpin G1 Protein, Mouse, Recombinant (His)
Serping1,Plasma protease C1 inhibitor,C1 Inh,C1 est... |
Mouse | Human Cells |
SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later... | |||
TMPY-03127 |
BAMBI Protein, Mouse, Recombinant (hFc)
2610003H06Rik,BMP and activin membrane-bound inhibitor |
Mouse | HEK293 |
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth f... | |||
TMPY-02187 |
SEMA5A Protein, Human, Recombinant (hFc)
SEMAF,serpin peptidase inhibitor, clade F,semF |
Human | HEK293 |
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 2 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse d... | |||
TMPY-01175 |
DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)
dickkopf WNT signaling pathway inhibitor 1 |
Rhesus | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majori... | |||
TMPY-02981 |
ING5 Protein, Human, Recombinant (GST)
p28ING5,inhibitor of growth family, member 5 |
Human | E. coli |
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRP... | |||
TMPY-02559 |
PAI-1 Protein, Rat, Recombinant (His)
serpin peptidase inhibitor, clade E (nexin, plasmin... |
Rat | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 def... | |||
TMPH-00520 | Host-nuclease inhibitor protein gam Protein, Enterobacteria phage lambda, Recombinant (His & Myc) | Escherichia phage lambda | E. coli |
Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis. | |||
TMPJ-00685 |
BAI3 Protein, Human, Recombinant (His)
BAI3,KIAA0550,Brain-Specific Angiogenesis Inhibitor... |
Human | Human Cells |
Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein, which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids in size. It contains three distinct regions: an N-terminal extracellular domain (ECD) (aa25-883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type 1 repeat (aa296-... | |||
TMPJ-00243 |
Serpin B6 Protein, Human, Recombinant (E. coli, His)
CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytop... |
Human | E. coli |
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se... | |||
TMPY-00397 |
ITIH3 Protein, Human, Recombinant (hFc)
H3P,SHAP,inter-α-trypsin inhibitor heavy chain 3,in... |
Human | HEK293 |
ITIH3 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 3) is a Protein Coding gene. This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. ITIH3 is involved in the stabilization of the extracellular matrix. A polymorphism (rs2535629) of ITIH3 showed the strongest association signal with susceptibility to psychiatric disorders in Caucasian populations. Common single nucleotide... | |||
TMPJ-00452 |
Serpin A1a Protein, Mouse, Recombinant (His)
Alpha-1-antitrypsin 1-1, Alpha-1 protease inhibitor... |
Mouse | Human Cells |
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. | |||
TMPJ-00502 |
Serpin G1 Protein, Human, Recombinant (His)
C1-Inhibiting Factor,Serpin G1,SERPING1,C1 Esterase Inhi... |
Human | Human Cells |
As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein. It is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain ... | |||
TMPY-00629 |
PAI-1 Protein, Rat, Recombinant (hFc)
serpin peptidase inhibitor, clade E (nexin, plasmin... |
Rat | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 def... | |||
TMPJ-00963 |
CDKN2C Protein, Human, Recombinant (His)
Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDK... |
Human | E. coli |
Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,... | |||
TMPY-01868 |
TIMP-2 Protein, Human, Recombinant
CSC-21K,DDC8,TIMP metallopeptidase inhibitor 2 |
Human | HEK293 |
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular response... | |||
TMPY-00933 |
TIMP-2 Protein, Human, Recombinant (hFc)
TIMP metallopeptidase inhibitor 2,DDC8,CSC-21K |
Human | HEK293 |
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular response... | |||
TMPY-00266 |
PEDF Protein, Rat, Recombinant (His)
serpin peptidase inhibitor, clade F,member 1 |
Rat | HEK293 |
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-a... | |||
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