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Pinostilbene

Name: Pinostilbene
Brand: TargetMol
SKU: T3755
Price: 179 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.21%

货号 T3755Cas号 42438-89-1

别名松茋

Pinostilbene 是一种 Pterostilbene 的主要代谢物，能够抑制结肠癌细胞。

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Pinostilbene

一键复制产品信息

很棒

纯度: 99.21%

货号 T3755 别名松茋Cas号 42438-89-1

Pinostilbene 是一种 Pterostilbene 的主要代谢物，能够抑制结肠癌细胞。

规格	价格	库存
1 mg	¥ 179	现货
2 mg	¥ 249	现货
5 mg	¥ 396	现货
10 mg	¥ 645	现货
25 mg	¥ 1,070	现货
1 mL x 10 mM (in DMSO)	¥ 393	现货

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纯度: 99.18%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Pinostilbene AI Summary

Pinostilbene exhibits a broad spectrum of bioactivity, displaying cytotoxic effects against various cancer cell lines with differing potencies. Specifically, it has IC50 values of 89100.0 nM for human HT1080, 91800.0 nM for A549, 48400.0 nM for HeLa, and 35800.0 nM for mouse Colon 26-L5 cells, while its impact on mouse B16-BL6 cells is limited (IC50 > 100000.0 nM). In nutrient-deprived conditions, it shows a PC50 of 71.4 uM against human PANC1 cells. The compound also demonstrates cytotoxicity against human HT-29 and Caco-2 cells with IC50 values of 33500.0 nM and 19210.0 nM, respectively, after 3 days. Additionally, it inhibits the growth of various tumor cell lines, including renal, lung, leukemia, melanoma, breast, ovarian, prostate, colon, and central nervous system cells, with GI50 values ranging from low nanomolar to higher concentrations. Pinostilbene is effective as an enzyme inhibitor. It shows potent inhibition of recombinant human CYP1B1 with IC50 and Ki values of 2100.0 nM and 900.0 nM, respectively, and CYP1A1 with a Ki value of 120.0 nM. It also inhibits COX-2 and 5-LOX enzymes with IC50 values of 250.0 nM and 4010.0 nM, respectively. Additionally, the compound exhibits antifungal activity against various Candida strains, with MIC95 values ranging from 18.0 ug ml-1 to 300.0 ug ml-1, suggesting its potential as an antifungal agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.
别名	松茋

化学信息

分子量	242.27
分子式	C₁₅H₁₄O₃
CAS No.	42438-89-1
Smiles	COc1cc(O)cc(\C=C\c2ccc(O)cc2)c1
密度	1.252g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (1011.27 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1276 mL	20.6381 mL	41.2763 mL	206.3813 mL
5 mM	0.8255 mL	4.1276 mL	8.2553 mL	41.2763 mL
10 mM	0.4128 mL	2.0638 mL	4.1276 mL	20.6381 mL
20 mM	0.2064 mL	1.0319 mL	2.0638 mL	10.3191 mL
50 mM	0.0826 mL	0.4128 mL	0.8255 mL	4.1276 mL
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0638 mL