Name: Flindokalner
Brand: TargetMol
SKU: T15286
Price: 337 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 337

现货

5 mg

¥ 768

现货

10 mg

¥ 1,090

现货

25 mg

¥ 2,350

现货

50 mg

¥ 3,370

现货

100 mg

¥ 4,720

现货

1 mL x 10 mM (in DMSO)

¥ 629

现货

产品介绍

生物活性

产品描述	Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
靶点活性	Kv7.4 channel:230 μM(Ki), Kv7.1 channel:3.7 μM(Ki), Kv7.5 channel:605 μM(Ki)
体外活性	Flindokalner inhibits cardiac L-type Ca2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes. Flindokalner (10 μM) inhibits Kv7.4and Kv7.5 (Kis: 230 and 605 μM, respectively)[1]. Flindokalner (1-10 μM) causes inhibition of the Ca2+ current in a dose-dependent manner (Kd: 6 μM and a Hill coefficient: 1.33) [2].
体内活性	Flindokalner (3-60 mg/kg; i.p.) engenders an anxiolytic profile, in a shock-based conditioned model of anxiety in male Wistar rats. Flindokalner (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect [1].
别名	BMS-204352

化学信息

分子量	359.7
分子式	C₁₆H₁₀ClF₄NO₂
CAS No.	187523-35-9
Smiles	COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
密度	1.50 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (278.01 mM), Sonication is recommended.

溶液配制表

DMSO

体内实验配液计算器