CpCDPK1/TgCDPK1-IN-1

Name: CpCDPK1/TgCDPK1-IN-1
Brand: TargetMol
SKU: T78605
Price: 1630 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.61%

货号 T78605Cas号 1092788-23-2

CpCDPK1/TgCDPK1-IN-1 是一种高效的 CpCDPK1 和 TgCDPK1 双重抑制剂，抑制 Abl 和 Src，具有抗寄生虫活性，适用于研究弓形虫感染和隐孢子虫病。

CpCDPK1/TgCDPK1-IN-1

一键复制产品信息

很棒

纯度: 99.61%

货号 T78605Cas号 1092788-23-2

CpCDPK1/TgCDPK1-IN-1 是一种高效的 CpCDPK1 和 TgCDPK1 双重抑制剂，抑制 Abl 和 Src，具有抗寄生虫活性，适用于研究弓形虫感染和隐孢子虫病。

规格	价格	库存
1 mg	¥ 1,630	现货
5 mg	¥ 4,900	现货
10 mg	¥ 5,930	现货
25 mg	¥ 7,630	现货

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产品介绍

CpCDPK1/TgCDPK1-IN-1 AI Summary

CpCDPK1/TgCDPK1-IN-1 exhibits bioactivity as a potent multi-target inhibitor. It effectively inhibits multiple PI3K isoforms (PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma) with IC50 values ranging from 1200.0 nM to 32000.0 nM, and displays significant inhibitory activity against DNA-PK with an IC50 value of 200.0 nM. Additionally, it has remarkable inhibitory effects on pathogens such as Cryptosporidium parvum and Toxoplasma gondii, with IC50 values of 10.0 nM and 5.0 nM, respectively. CpCDPK1/TgCDPK1-IN-1 also demonstrates potent inhibition in kinase assays against Toxoplasma gondii CDPK1, Cryptosporidium parvum CDPK1, human SRC, and human ABL kinases, highlighting its potential therapeutic applications in targeting these enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections and cryptosporidiosis.
靶点活性	TgCDPK1:5.0 nM, CpCDPK1:10 nM

化学信息

分子量	303.36
分子式	C₁₈H₁₇N₅
CAS No.	1092788-23-2
Smiles	N=1C=NC2=C(C1N)C(=NN2C(C)C)C=3C=CC=4C=CC=CC4C3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (329.64 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2964 mL	16.4821 mL	32.9641 mL	164.8207 mL
5 mM	0.6593 mL	3.2964 mL	6.5928 mL	32.9641 mL
10 mM	0.3296 mL	1.6482 mL	3.2964 mL	16.4821 mL
20 mM	0.1648 mL	0.8241 mL	1.6482 mL	8.2410 mL
50 mM	0.0659 mL	0.3296 mL	0.6593 mL	3.2964 mL
100 mM	0.0330 mL	0.1648 mL	0.3296 mL	1.6482 mL