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PSNCBAM-1

Name: PSNCBAM-1
Brand: TargetMol
SKU: T28468
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T28468Cas号 877202-74-9

别名 PSNCBAM 1

PSNCBAM-1 (PSNCBAM 1) 是一种 CB1 受体负变构调节剂 (EC50 = 0.1 μM)，在体内具有吞噬作用。 PSNCBAM-1 可用于肥胖研究。

为众多的药物研发团队赋能，

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PSNCBAM-1

一键复制产品信息

很棒

纯度: 99.86%

货号 T28468 别名 PSNCBAM 1Cas号 877202-74-9

PSNCBAM-1 (PSNCBAM 1) 是一种 CB1 受体负变构调节剂 (EC50 = 0.1 μM)，在体内具有吞噬作用。 PSNCBAM-1 可用于肥胖研究。

规格	价格	库存
1 mg	¥ 413	现货
2 mg	¥ 579	现货
5 mg	¥ 928	现货
10 mg	¥ 1,450	现货
25 mg	¥ 2,480	现货
50 mg	¥ 3,690	现货
100 mg	¥ 5,270	现货
1 mL x 10 mM (in DMSO)	¥ 987	现货

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纯度: 99.86%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

PSNCBAM-1 AI Summary

PSNCBAM-1 exhibits multifaceted bioactivities targeting cannabinoid receptors, particularly the human CB1 receptor. It functions as both an antagonist and negative allosteric modulator, with an IC50 of 32.5 nM as an antagonist and an IC50 of 33.0 nM for inhibiting CP55,940-induced calcium mobilization. Additionally, it acts as a positive allosteric modulator, enhancing [3H]CP55,940 binding, with a binding affinity (Kb) of 54.3 nM, and inhibition effects with IC50 values ranging from 42.0 to 89.0 nM, as well as an EC50 of 270.0 nM for [3H]CP55,940 binding induction. The compound also possesses partial agonist activity at the CB1 receptor, showing a 28.2% activity relative to CP55,940. At the CB2 receptor, PSNCBAM-1 demonstrates weak antagonist activity with an IC50 above 10,000 nM and negligible agonist activity with an Emax of less than 10.0%. Aside from its cannabinoid receptor interactions, PSNCBAM-1 exhibits significant antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in various cell lines. It achieves an 8.84% inhibition in Caco-2 cells at 10 µM concentration and inhibits the SARS-CoV-2 3CL-Pro protease by 21.22% at 20 µM concentration. The compound also inhibits enzymes like FAAH (IC50 of 2100 nM) and exhibits mixed effects in enzymatic assays of human HDAC6, suggesting varying levels of inhibition depending on the substrate. Furthermore, thermal shift assays indicate that PSNCBAM-1 influences the thermal stability of specific domains, with mixed increases and decreases in thermal stability. In conclusion, PSNCBAM-1 is a complex bioactive molecule with notable interactions at human cannabinoid receptors, marked by both antagonist and modulator activities, alongside antiviral and enzyme inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
靶点活性	CB1 receptor (human):0.1 μM (EC50)
别名	PSNCBAM 1

化学信息

分子量	392.88
分子式	C₂₂H₂₁ClN₄O
CAS No.	877202-74-9
Smiles	N(C(NC1=CC=C(Cl)C=C1)=O)C=2C=C(C=3N=C(C=CC3)N4CCCC4)C=CC2
密度	1.332 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (139.99 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5453 mL	12.7265 mL	25.4531 mL	127.2653 mL
5 mM	0.5091 mL	2.5453 mL	5.0906 mL	25.4531 mL
10 mM	0.2545 mL	1.2727 mL	2.5453 mL	12.7265 mL
20 mM	0.1273 mL	0.6363 mL	1.2727 mL	6.3633 mL
50 mM	0.0509 mL	0.2545 mL	0.5091 mL	2.5453 mL
100 mM	0.0255 mL	0.1273 mL	0.2545 mL	1.2727 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。