P300/CBP-IN-5 inhibits H3K27Ac with an IC50 value of 4.6 nM in PC-3 cells,P300/CBP-IN-5 inhibits p300 LnCap-FGC cellls proliferation with an IC50 of 14.8 nM.?[1].

Administration of P300/CBP-IN-5 (7.5 mg/kg/day) is initiated at the time of size match.?P300/CBP-IN-5 induces significant tumor growth inhibition in multiple xenograft tumor models (the tumor growth inhibition of 62% in SuDHL-8 xenograft tumor model;?48% in 22RV1 xenograft tumor model)[1].