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UNC0646

Name: UNC0646
Brand: TargetMol
SKU: TQ0232
Price: 263 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: UNC 0646

货号 TQ0232Cas号 1320288-17-2 一键复制产品信息

很棒

UNC0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂，IC50分别为 6 和 15 nM，对 G9a/GLP 的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平，IC50为 26 nM。

UNC0646

一键复制产品信息

很棒

货号 TQ0232Cas号 1320288-17-2

别名 UNC 0646

规格	价格	库存
1 mg	¥ 263	现货
5 mg	¥ 617	现货
10 mg	¥ 872	现货
25 mg	¥ 1,630	现货
50 mg	¥ 2,920	现货
100 mg	¥ 4,230	现货
1 mL x 10 mM (in DMSO)	¥ 845	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: >99.99%

颜色: 白色

性状: Solid

资源下载: COA产品操作手册

产品介绍

UNC0646 AI Summary

UNC0646 exhibits bioactivities encompassing significant inhibition of the enzyme G9a, with IC50 values ranging from 6.0 nM to 86.0 nM in various cell lines. It demonstrates moderate cytotoxicity against several human cell lines, with EC50 values ranging from 2800.0 nM to 12000.0 nM after 48 hours. Its selectivity is indicated by varying EC50 to IC50 ratios across different cell lines. The compound exhibits negligible or weak inhibition against other enzymes such as GLP, PRMT3, SETD7, SUV39H2, and SETD8. In the context of antiviral activity, UNC0646 inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells at a concentration of 10 µM, displaying a modest inhibition of 2.23%. It shows inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM with inhibition percentages of 2.65% and 7.307%. In VERO-6 cells, the compound demonstrates inhibition percentages against SARS-CoV-2 ranging from 46.28% to 93.73%, and a selectivity index between 0.56 to 2.74. The IC50 values for inhibiting virus-induced cytotoxicity vary between 12030.0 nM and greater than 33000.0 nM, while the toxicity CC50 values against VERO-E6 cells range from greater than 33000.0 nM to 18620.0 nM. Furthermore, UNC0646 shows inhibition of human HDAC6 enzyme, with 27.78% inhibition for a commercial peptide substrate assay and 8.06% for a custom peptide substrate assay. It also displays bioactivity in inhibiting SARS-CoV-2-induced cytopathy with an IC50 value of 17.22 µM, assessed via fluorescence imaging four days post-infection of EGFP-labeled Green monkey Vero cells. Additionally, it exhibits cytotoxicity against human HepG2 cells with an IC50 value of 6600.0 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
靶点活性	G9a:6 nM, GLP:15 nM
别名	UNC 0646

化学信息

分子量	621.9
分子式	C₃₆H₅₉N₇O₂
CAS No.	1320288-17-2
Smiles	COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
密度	1.128 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 30 mg/mL (48.24 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.43 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6080 mL	8.0399 mL	16.0798 mL	80.3988 mL
5 mM	0.3216 mL	1.6080 mL	3.2160 mL	16.0798 mL
10 mM	0.1608 mL	0.8040 mL	1.6080 mL	8.0399 mL
20 mM	0.0804 mL	0.4020 mL	0.8040 mL	4.0199 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。