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Mdivi-1 (Mitochondrial division inhibitor 1) 是一种线粒体分裂抑制剂,抑制 DRP1 和 Dynamin I (IC50=1-10 μM)。Mdivi-1 可以抑制线粒体自噬。
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Mdivi-1 (Mitochondrial division inhibitor 1) 是一种线粒体分裂抑制剂,抑制 DRP1 和 Dynamin I (IC50=1-10 μM)。Mdivi-1 可以抑制线粒体自噬。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 153 | In stock | |
5 mg | ¥ 315 | In stock | |
10 mg | ¥ 523 | In stock | |
25 mg | ¥ 987 | In stock | |
50 mg | ¥ 1,790 | In stock | |
100 mg | ¥ 2,530 | In stock | |
200 mg | ¥ 3,730 | In stock | |
500 mg | ¥ 5,950 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 315 | In stock |
Mdivi-1 相关产品
产品描述 | Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy. |
靶点活性 | Dnm1 GTPase:1 μM-10 μM, POP92:15 µM, MDA-MB-231 cells:55.93 ± 1.92 μM |
体外活性 | 方法:人乳腺癌细胞 MDA-MB-231 用 Mdivi-1 (5-40 μM) 处理 8 h,使用 Immunostaining 方法分析有丝分裂纺锤体的异常。 |
体内活性 | 方法:为检测体内活性,将 Mdivi-1 (50 mg/kg) 腹腔注射给 C57BL/6 小鼠,随后通过急性眼压升高诱导短暂的视网膜缺血。 |
激酶实验 | All GTPase assay reactions are started in a 200 μL volume, of which 150 μL is placed into the well of a 96-well plate. Depletion of NADH, as monitored by reading the A340 of the reaction, is measured every 20 s for a total of 40 min using a SpectraMAX 250 96-well plate reader. Spectrophotometric data are transferred to Excel and the measured steady state depletion of NADH over time is converted to protein activity. |
细胞实验 | Mdivi-1 is dissolved in DMSO. YPGlycerol plates are topped with 10 mL YPGlycerol containing 1% low melt agar and 75 μM mdivi-1, and cells are spotted 12 hours later using a 48 well pinning device. After pinning cells, plates are incubated at 24°C or 37°C and imaged using an Eagle Eye II imaging system. |
别名 | Mitochondrial division inhibitor 1 |
分子量 | 353.22 |
分子式 | C15H10Cl2N2O2S |
CAS No. | 338967-87-6 |
Smiles | O=C1N(C(=S)NC=2C1=CC=CC2)C3=CC(OC)=C(Cl)C=C3Cl |
密度 | 1.57 g/cm3 (Predicted) |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (141.55 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.53 mg/mL (9.99 mM), Suspension. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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