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Diethylcarbamazine citrate

Name: Diethylcarbamazine citrate
Brand: TargetMol
SKU: T1420
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 枸橼酸乙胺嗪, Loxuran, Dicarocide, Caritrol

货号 T1420Cas号 1642-54-2 一键复制产品信息纯度: 99.61%

很棒

Diethylcarbamazine citrate (Caritrol) 是驱肠虫药，主要用作治疗丝虫病的柠檬酸盐，是丝虫微丝蚴的花生四烯酸代谢抑制剂。

Diethylcarbamazine citrate

一键复制产品信息

很棒

纯度: 99.61%

货号 T1420Cas号 1642-54-2

别名 枸橼酸乙胺嗪, Loxuran, Dicarocide, Caritrol

Diethylcarbamazine citrate (Caritrol) 是驱肠虫药，主要用作治疗丝虫病的柠檬酸盐，是丝虫微丝蚴的花生四烯酸代谢抑制剂。

规格	价格	库存
25 mg	¥ 133	现货
50 mg	¥ 173	现货
100 mg	¥ 289	现货
500 mg	¥ 662	现货
1 g	¥ 973	现货
1 mL x 10 mM (in DMSO)	¥ 318	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.61%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR HPLC产品操作手册

产品介绍

Diethylcarbamazine citrate AI Summary

Diethylcarbamazine citrate exhibits significant microfilaricidal activity across multiple in vivo models. For Acanthocheilonema viteae infection in Mastomys natalensis and Mastomys coucha, it achieves a 90% reduction in activity at doses ranging from 50 to 200 mg/kg over 5 days, although it shows no macrofilaricidal activity. Similarly, for Litomosoides carinii in Mastomys coucha and cotton rats, it results in a 90-98% reduction in microfilariae at doses of 6 to 100 mg/kg, without affecting adult worms. The compound does not impact glucose uptake, lactate production, or ATP content in Acanthocheilonema viteae, nor does it demonstrate sterility effects on female worms. Additionally, Diethylcarbamazine citrate shows antifilarial activity against Brugia malayi, reducing worm burden and sterilizing female worms in Meriones unguiculatus and Mastomys coucha. In various assays, it inhibits multiple biomolecular targets, such as Human Jumonji Domain Containing 2E (JMJD2E), 15-human lipoxygenase, Aldehyde Dehydrogenase 1 (ALDH1A1), and more. It also exhibits antiviral properties, showing inhibition against SARS-CoV-2-induced cytotoxicity in Caco-2 and Vero E6 cells, though with varying levels of efficacy. Overall, Diethylcarbamazine citrate is a versatile agent with significant antifilarial and antiviral bioactivities, but it shows limited efficacy against macrofilariae and specific biochemical pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid metabolism in filarial microfilaria.
别名	枸橼酸乙胺嗪, Loxuran, Dicarocide, Caritrol

化学信息

分子量	391.42
分子式	C₁₀H₂₁N₃O·C₆H₈O₇
CAS No.	1642-54-2
Smiles	OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1
密度	1.1718 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (127.74 mM), Sonication is recommended.

Ethanol: 30 mg/mL (76.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.11 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5548 mL	12.7740 mL	25.5480 mL	127.7400 mL
5 mM	0.5110 mL	2.5548 mL	5.1096 mL	25.5480 mL
10 mM	0.2555 mL	1.2774 mL	2.5548 mL	12.7740 mL
20 mM	0.1277 mL	0.6387 mL	1.2774 mL	6.3870 mL
50 mM	0.0511 mL	0.2555 mL	0.5110 mL	2.5548 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2774 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Parasite Inhibitor inhibit Diethylcarbamazine Citrate Diethylcarbamazine COX-1 ALOX5

Diethylcarbamazine citrate

Diethylcarbamazine citrate