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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Propylthiouracil

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纯度: 99.24%

货号 T1309Cas号 51-52-5

别名 丙硫氧嘧啶, Pseudocapsaicin, NSC 70461, NSC 6498, 6-Propyl-2-thiouracil, 6-n-Propylthiouracil

Propylthiouracil (6-n-Propylthiouracil) 是一种甲状腺过氧化物酶抑制剂，也是一种5'-脱碘酶抑制剂。

Propylthiouracil
其他形式的 “Propylthiouracil”:
Propylthiouracil (Standard)
Nonivamide

Propylthiouracil

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Rating icon 很棒

纯度: 99.24%

货号 T1309 别名 丙硫氧嘧啶, Pseudocapsaicin, NSC 70461, NSC 6498, 6-Propyl-2-thiouracil, 6-n-PropylthiouracilCas号 51-52-5

Propylthiouracil (6-n-Propylthiouracil) 是一种甲状腺过氧化物酶抑制剂，也是一种5'-脱碘酶抑制剂。

规格价格库存数量
10 mg
¥ 166
现货
25 mg
¥ 248
现货
50 mg
¥ 349
现货
100 mg
¥ 498
现货
500 mg
¥ 758
现货
1 g
¥ 1,090
现货
1 mL x 10 mM (in DMSO)
¥ 198
现货
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纯度: 99.24%
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产品介绍

Propylthiouracil AI Summary
Propylthiouracil demonstrates a diverse range of bioactivities, including binding to human serum albumin with a binding constant of Log K' = 0.75 and notable inhibition of Human Placenta Inner-Ring Iodothyronine 5-deiodinase at 5 mM, showing 29.0% inhibition. It exhibits dose-dependent inhibition of rT3 production in varying DTT concentrations. The compound has significant oral bioavailability (78.0% to 85.0%) and a bioavailability-related activity such as total body clearance (3.1 mL.min^-1.kg^-1) and renal clearance (0.04 mL.min^-1.kg^-1). Pharmacokinetically, it shows moderate drug absorption (human intestinal absorption activity of 0.76%) and low transcellular permeability (logPapp -3.66 to -4.02), alongside a fraction unbound (Fu) of 0.18 and a volume of distribution at steady state (Vdss) of 0.34 L.kg^-1. Propylthiouracil has a human half-life (T1/2) of 1.3 hours and a mean residence time (MRT) of 1.8 hours. The compound demonstrates extensive bioactivity across various assays, including modulation of Lamin A splicing, agonism of the Thyroid Stimulating Hormone Receptor, and inhibition of enzymes such as Sfp phosphopantetheinyl transferase and Histone Lysine Methyltransferase G9a. It also shows activity as an antagonist of PPAR gamma and an agonist of the vitamin D receptor pathway, with significant impacts on hepatic functions marked by moderate to severe liver toxicity indicated by elevated ALT, AST, and alkaline phosphatase levels. Notably, it exhibits inhibitory activity against human CYP3A4 enzyme and transporters such as OATP1B3 and OATP1B1, with significant inhibition rates of 90.71% and 79.91% respectively at 10 μM. Propylthiouracil shows antiviral activity against SARS-CoV-2, albeit marginally effective, and has shown inhibitory activity in reducing cytotoxic effects in VERO-6 cells and Caco-2 cells. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease enzyme and exhibits antifungal and antibacterial activities against several pathogens including Candida albicans, Escherichia coli, and Acinetobacter baumannii. The compound also affects lipid metabolism in Wistar rats by inhibiting L-T4-induced changes in cholesterol levels and inhibits human HDAC6 as well as mushroom tyrosinase. Despite these activities, its binding affinity towards various receptors and ion channels remains relatively low. Overall, Propylthiouracil is characterized by significant bioactivities across multiple biochemical pathways and a high potential for drug-induced liver injury..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
别名丙硫氧嘧啶, Pseudocapsaicin, NSC 70461, NSC 6498, 6-Propyl-2-thiouracil, 6-n-Propylthiouracil
化学信息
分子量170.23
分子式C7H10N2OS
CAS No.51-52-5
SmilesCCCC1=CC(O)=NC(S)=N1
密度1.1880 g/cm3 (Estimated)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 65 mg/mL (381.84 mM), Sonication is recommended.
Ethanol: 16 mg/mL (93.99 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.75 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.8744 mL29.3720 mL58.7441 mL293.7203 mL
5 mM1.1749 mL5.8744 mL11.7488 mL58.7441 mL
10 mM0.5874 mL2.9372 mL5.8744 mL29.3720 mL
20 mM0.2937 mL1.4686 mL2.9372 mL14.6860 mL
50 mM0.1175 mL0.5874 mL1.1749 mL5.8744 mL
DMSO
1mg5mg10mg50mg
100 mM0.0587 mL0.2937 mL0.5874 mL2.9372 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Thyroidhormonereceptor(THR)ThyroidhormonereceptorThyroid peripheral conversionThyroid hormone receptor(THR)Thyroid hormone receptorTHRPTUPropylthiouracilNSC-70461NSC70461NSC-6498NSC6498
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