3-pyridine toxoflavin

Name: 3-pyridine toxoflavin
Brand: TargetMol
SKU: T67738
Price: 1290 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T67738Cas号 32502-20-8

别名 3-吡啶毒黄素

3-pyridine toxoflavin 是一种有效的 KDM4C 抑制剂，IC50=19 nM。

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3-pyridine toxoflavin

一键复制产品信息

很棒

纯度: 99.93%

货号 T67738 别名 3-吡啶毒黄素Cas号 32502-20-8

3-pyridine toxoflavin 是一种有效的 KDM4C 抑制剂，IC50=19 nM。

规格	价格	库存
1 mg	¥ 1,290	现货
5 mg	¥ 2,990	现货
10 mg	¥ 4,390	现货
25 mg	¥ 6,910	现货
50 mg	¥ 9,480	现货
100 mg	¥ 12,800	现货
500 mg	¥ 25,600	现货
1 mL x 10 mM (in DMSO)	¥ 2,590	现货

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产品介绍

3-pyridine toxoflavin AI Summary

3-pyridine toxoflavin has demonstrated significant bioactivity across multiple assays and various biological targets. It exhibits inhibitory potency against Cruzain, Nrf2, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Giardia lamblia, TGF-β, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and Vaccinia Orthopoxvirus, with varying potencies ranging from 1155.4 nM to 19952.6 nM. Additionally, it inhibits KDM4C with an IC50 of 19.0 nM. The compound also shows cytotoxicity against human THLE cells with EC50 values of 3100.0 nM after 72 hours, 5800.0 nM after 24 hours, and 11700.0 nM after 4 hours. It induces reactive oxygen species (ROS) generation, specifically H2O2, with an EC50 of 1000.0 nM after 60 minutes. Further bioactivity includes antiproliferative effects on human HepG2 cells (IC50 of 1800.0 nM) and A549 cells (IC50 of 4300.0 nM). The compound has a cell permeability rate of 13.4 x 10^-6 cm/s, intrinsic clearance in mouse liver microsomes at 11.6 µL/min, and displays a high basolateral to apical efflux ratio, indicating efficient cellular permeability and potential for high-throughput applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.
别名	3-吡啶毒黄素

化学信息

分子量	270.25
分子式	C₁₂H₁₀N₆O₂
CAS No.	32502-20-8
Smiles	O=C1C=2C(N(C)N=C(N2)C=3C=CN=CC3)=NC(=O)N1C
密度	1.55 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (166.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7003 mL	18.5014 mL	37.0028 mL	185.0139 mL
5 mM	0.7401 mL	3.7003 mL	7.4006 mL	37.0028 mL
10 mM	0.3700 mL	1.8501 mL	3.7003 mL	18.5014 mL
20 mM	0.1850 mL	0.9251 mL	1.8501 mL	9.2507 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7003 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8501 mL