规格

价格

库存

数量

1 mg

¥ 378

现货

5 mg

¥ 528

现货

10 mg

¥ 738

现货

25 mg

¥ 1,820

现货

50 mg

¥ 2,650

现货

100 mg

¥ 4,560

现货

1 mL x 10 mM (in DMSO)

¥ 658

现货

生物活性

产品描述

8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating an inhibitory concentration (IC 50) of 0.9 μM. Additionally, this compound inhibits PDE III and PDE IV, while significantly activating Epac, showcasing its diverse pharmacological activities [1] [2].

体外活性

a-Fas and TNF-α/CHX induces neutrophil death rapidly (within 2 h) to at least 90%. The commonly used cAMP analog 8-pCPT-cAMP (0.7 mM) delays TNF- /CHX-induced and a-Fas-induced apoptosis. It is more efficient against TNF- /CHX-induced apoptosis than against a-Fas [2].

化学信息

分子量	493.79
分子式	C₁₆H₁₄ClN₅NaO₆PS
CAS No.	93882-12-3
Smiles	NC1=C2C(N([C@@H]3O[C@@]4([H])[C@](OP([O-])(OC4)=O)([H])[C@H]3O)C(SC5=CC=C(C=C5)Cl)=N2)=NC=N1.[Na+]
密度	no data available
颜色	Yellow
物理性状	Solid