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Brequinar sodium

Name: Brequinar sodium
Brand: TargetMol
SKU: T8332
Price: 209 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 布喹那钠盐, NSC 368390 sodium, DuP785 sodium

货号 T8332Cas号 96201-88-6 一键复制产品信息纯度: 98.16%

很棒

Bipenquinate 是一种有效的、选择性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC50 为 20 nM，阻断嘧啶的从头生物合成。

Brequinar sodium

一键复制产品信息

很棒

纯度: 98.16%

货号 T8332Cas号 96201-88-6

别名 布喹那钠盐, NSC 368390 sodium, DuP785 sodium

Bipenquinate 是一种有效的、选择性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC50 为 20 nM，阻断嘧啶的从头生物合成。

规格	价格	库存
1 mg	¥ 209	现货
5 mg	¥ 533	现货
10 mg	¥ 833	现货
25 mg	¥ 1,580	现货
50 mg	¥ 2,270	现货
100 mg	¥ 3,130	现货
200 mg	¥ 4,120	现货
1 mL x 10 mM (in DMSO)	¥ 559	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.16%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Brequinar sodium AI Summary

Brequinar sodium is a potent inhibitor of human recombinant dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value as low as 8.0 nM and a Ki value of 12.0 nM. It demonstrates significant antiproliferative activity in human lymphocytes, as evidenced by an IC50 value of 15.0 nM in the mixed lymphocyte reaction test. Additionally, Brequinar sodium shows broad-spectrum growth inhibition across various human tumor cell lines, with GI50 values ranging from 56.62 nM to 155238.7 nM, highlighting its potential as an anti-cancer agent. It also exhibits cytotoxic effects on A375, Hep3B, HCT116, BxPC3, WI38, HT-29, and MDA-MB-231 cell lines, with varying IC50 values, and inhibits DHODH activity significantly, achieving up to 97.29% inhibition at 10 µM. Furthermore, Brequinar sodium demonstrates notable antiviral properties, particularly against SARS-CoV-2, by reducing virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Its SARS-CoV-2 3CL-Pro protease inhibition, however, is minimal at 0.795% at 20 µM. The compound also increases IFN-alpha mediated responses in HEK-293 cells with an EC50 of 54.95 nM. These multifaceted biological activities suggest that Brequinar sodium is a promising candidate for further investigations in cancer and antiviral therapies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
别名	布喹那钠盐, NSC 368390 sodium, DuP785 sodium

化学信息

分子量	397.36
分子式	C₂₃H₁₄F₂NNaO₂
CAS No.	96201-88-6
Smiles	[Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c1ccc(cc1)-c1ccccc1F
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 3.98 mg/mL (10.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5166 mL	12.5830 mL	25.1661 mL	125.8305 mL
5 mM	0.5033 mL	2.5166 mL	5.0332 mL	25.1661 mL
10 mM	0.2517 mL	1.2583 mL	2.5166 mL	12.5830 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。