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Solithromycin

Name: Solithromycin
Brand: TargetMol
SKU: T2331
Price: 218 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.42%

货号 T2331Cas号 760981-83-7

别名 索利霉素, OP-1068, CEM-101

Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。

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Solithromycin

一键复制产品信息

很棒

纯度: 99.42%

货号 T2331 别名 索利霉素, OP-1068, CEM-101Cas号 760981-83-7

规格	价格	库存
1 mg	¥ 218	现货
5 mg	¥ 496	现货
10 mg	¥ 828	现货
25 mg	¥ 1,660	现货
50 mg	¥ 2,480	现货
100 mg	¥ 3,690	现货
200 mg	¥ 5,320	现货
1 mL x 10 mM (in DMSO)	¥ 772	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.58%

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COA HPLC HNMR 产品操作手册

产品介绍

Solithromycin AI Summary

Solithromycin exhibits broad-spectrum antimicrobial activity, demonstrating efficacy against various bacterial strains, including Staphylococcus aureus (wild type and resistant strains), Escherichia coli, Acinetobacter baumannii, Enterococcus faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Notably, it shows high potency with minimum inhibitory concentrations (MICs) ranging from 0.006 μg/mL to 9500 nM against different strains. The compound binds to the 70S ribosome of Escherichia coli with a dissociation constant (Kd) of 0.6 nM and inhibits ribosomal activity, reducing protein synthesis by 47%. It also binds to the Staphylococcus aureus 70S ribosome with a Ki value of 60.3 nM. Moreover, Solithromycin exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells and Vero cells and shows a 19.47% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration. It also shows moderate inhibition of the human HDAC6 enzyme, with inhibition percentages of 17.24% and 8.49% using different peptide substrates. These diverse bioactivities highlight Solithromycin as a promising candidate for further therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.
靶点活性	Streptococcus pneumoniae:7.5 ng/ml, Haemophilus influenzae:125 ng/ml, S. aureus:40 ng/ml
别名	索利霉素, OP-1068, CEM-101

化学信息

分子量	845.01
分子式	C₄₃H₆₅FN₆O₁₀
CAS No.	760981-83-7
Smiles	CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(nn3)-c3cccc(N)c3)C(=O)O[C@]12C)OC
密度	1.30 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (59.17 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.37 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1834 mL	5.9171 mL	11.8342 mL	59.1709 mL
5 mM	0.2367 mL	1.1834 mL	2.3668 mL	11.8342 mL
10 mM	0.1183 mL	0.5917 mL	1.1834 mL	5.9171 mL
20 mM	0.0592 mL	0.2959 mL	0.5917 mL	2.9585 mL
50 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1834 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。