Name: Broussochalcone A
Brand: TargetMol
SKU: T72594
Price: 1880 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,880

In stock

5 mg

¥ 4,890

In stock

10 mg

¥ 6,780

In stock

25 mg

¥ 9,870

In stock

产品介绍

生物活性

产品描述

Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 μM) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.

体外活性

方法：Broussochalcone A (1-30 μM) 与 DPPH (100 μM) 在室温下孵育 30 分钟，然后测量 517 nm 处吸光度的下降。研究BCA 的 DPPH 清除活性。
结果：Broussochalcone A 的清除活性都是浓度依赖性的。
方法：Broussochalcone A（1-20μM）处理细胞 30 分钟，然后用 LPS (1 mg/mL) 刺激。24 小时后，通过 Griess 反应分析培养基中的亚硝酸盐水平。研究其对 LPS 激活的 RAW 264.7巨噬细胞中亚硝酸盐生成的影响。
结果：Broussochalcone A 浓度依赖性地抑制亚硝酸盐生成，其 IC50 值计算为 11.3±0.8 μM。[2]

化学信息

分子量	340.37
分子式	C₂₀H₂₀O₅
CAS No.	99217-68-2
Smiles	C(/C=C/C1=CC(O)=C(O)C=C1)(=O)C2=CC(CC=C(C)C)=C(O)C=C2O

储存&溶解度

存储

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (235.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9380 mL	14.6899 mL	29.3798 mL	146.8990 mL
5 mM	0.5876 mL	2.9380 mL	5.8760 mL	29.3798 mL
10 mM	0.2938 mL	1.4690 mL	2.9380 mL	14.6899 mL
20 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3449 mL
50 mM	0.0588 mL	0.2938 mL	0.5876 mL	2.9380 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4690 mL

体内实验配液计算器