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Chlorhexidine

Name: Chlorhexidine
Brand: TargetMol
SKU: T1000
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氯己定, Rotersept, Nolvasan, Chlorhexidinum

货号 T1000Cas号 55-56-1 一键复制产品信息纯度: 99.85%

很棒

Chlorhexidine (Rotersept) 是一种抗菌剂和防腐剂。它可用于注射前、手术前或外伤后清洁皮肤。

Chlorhexidine

一键复制产品信息

很棒

纯度: 99.85%

货号 T1000Cas号 55-56-1

别名 氯己定, Rotersept, Nolvasan, Chlorhexidinum

Chlorhexidine (Rotersept) 是一种抗菌剂和防腐剂。它可用于注射前、手术前或外伤后清洁皮肤。

规格	价格	库存
10 mg	¥ 129	现货
25 mg	¥ 185	现货
50 mg	¥ 253	现货
100 mg	¥ 413	现货
500 mg	¥ 662	现货
1 g	¥ 973	现货
1 mL x 10 mM (in DMSO)	¥ 148	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.85%

颜色: 白色

资源下载: COA LCMS HPLC HNMR产品操作手册

产品介绍

Chlorhexidine AI Summary

Chlorhexidine exhibits a broad spectrum of bioactivity, including significant antibacterial properties against a variety of bacterial strains such as Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Porphyromonas gingivalis. The minimum inhibitory concentrations (MICs) range from 0.0007 μg/mL to over 50 μg/mL, with notable antimicrobial effects against Staphylococcus aureus, Bacillus subtilis, Providencia stuartii, and Streptococcus sobrinus. Additionally, it shows strong antibiofilm activity against Streptococcus mutans and Candida albicans. Chlorhexidine also inhibits HIV-1 integrase with significant inhibition above 50% at 1 mM concentration. It demonstrates antiviral activity against SARS-CoV-2 in Vero E6 cells, albeit with lower potency. The compound shows notable enzyme inhibition, including Trypanosoma cruzi trypanothione reductase and human glutathione reductase. It inhibits the phosphatase activities of SYNJ1 and SYNJ2, with IC50 values of 10,000 nM and ≤15,900 nM, respectively. In terms of transporter activity, Chlorhexidine inhibits organic cation transporters OCT1, OCT2, OCT3, MATE1, and MATE2K with IC50 values ranging from 210 nM to 700 nM. Additionally, it displaces neuropeptide Y1 and ETA receptors with high efficacy and exhibits potent inhibition of gelatinase A and B in human cells. Although Chlorhexidine shows no significant prediction for liver injury, it does exhibit moderate acute liver toxicity and cytotoxicity in human and mouse cell lines with variations in selectivity indices and CC50 values. The compound has a high partition coefficient (LogP = 4.78) and displays high activity in displacing [3H]NPY and [3H]BQ-123 from their respective receptors, indicating potential relevance in pharmacokinetics. Overall, Chlorhexidine shows promise as an antimicrobial agent, enzyme inhibitor, and modulator of organic cation transport, with diverse bioactivities across various assays and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Chlorhexidine (Rotersept) is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram-positive bacteria are more negatively charged, they are more sensitive to this agent.

别名

氯己定, Rotersept, Nolvasan, Chlorhexidinum

化学信息

分子量	505.45
分子式	C₂₂H₃₀Cl₂N₁₀
CAS No.	55-56-1
Smiles	Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
密度	1.39 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 22.73 mg/mL (44.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9784 mL	9.8922 mL	19.7844 mL	98.9218 mL
5 mM	0.3957 mL	1.9784 mL	3.9569 mL	19.7844 mL
10 mM	0.1978 mL	0.9892 mL	1.9784 mL	9.8922 mL
20 mM	0.0989 mL	0.4946 mL	0.9892 mL	4.9461 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit HNMT Chlorhexidine CAT Bacterial Antibiotic

Chlorhexidine

Chlorhexidine

Chlorhexidine 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词