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Bohemine

Name: Bohemine
Brand: TargetMol
SKU: T2029
Price: 109 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.53%

货号 T2029Cas号 189232-42-6

Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。

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Bohemine

一键复制产品信息

很棒

纯度: 99.53%

货号 T2029Cas号 189232-42-6

Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。

规格	价格	库存
1 mg	¥ 109	现货
5 mg	¥ 222	现货
10 mg	¥ 363	现货
25 mg	¥ 728	现货
50 mg	¥ 1,080	现货
100 mg	¥ 1,650	现货
200 mg	¥ 2,460	现货
1 mL x 10 mM (in DMSO)	¥ 245	现货

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产品介绍

Bohemine AI Summary

Bohemine is a multi-target inhibitor with notable bioactivities across various assays and biological systems. It inhibits Cyclin-dependent kinase 1 (CDK1) with an IC50 of 2500 nM and Cyclin-dependent kinase 2 (CDK2) with an IC50 of 800 nM. Additionally, it inhibits recombinant CDK1-cyclin B with an IC50 of 1100 nM and demonstrates broad in vitro cytotoxic effects on several cancer cell lines, including MCF-7, K562, CEM, HOS, and G361 with IC50 values of 28000 nM, 113000 nM, 27000 nM, 58000 nM, and 45000 nM, respectively. Bohemine shows further kinase inhibition with an IC50 of 1000 nM and induces thermal stabilization across multiple protein kinases such as AMPKA2, CAMKs, CK1 family members, PIMs, PLKs, RSKs, SLK, MPSK1, TNIK, PBK, and YSK1, suggesting broad-spectrum kinase interaction. Apart from kinase inhibition, Bohemine inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) and GCN5L2 with potencies of 35481.3 nM and 31622.8 nM, respectively, and blocks the interaction between CBF-beta and RUNX1, showing potential for treating Acute Myeloid Leukemia with a potency of 31622.8 nM. The compound also exhibits agonistic activity at N-type Cav2.2 channels in tsA201 cells, although with an EC50 value greater than 1000000 nM, implying weak activity in this context. In cellular assays, Bohemine displays cytotoxicity against human BJ cells at 30 µM with 119.8% activity relative to control after 72 hours and shows leishmanicidal activity against Leishmania turanica promastigotes with an activity of 55.4% at the same concentration and time point. Additionally, it inhibits Leishmania CRK3/CYC6 using histone H1/[gamma33-P]ATP as a substrate at 30 µM, with a 49.2% inhibition rate after 30 minutes compared to the control..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bohemine is a cyclin-dependent kinase inhibitor.
靶点活性	CDK2-CyclinE:4.6 μM (IC50), ERK2:52 μM (IC50), CDK2-CyclinA:83 μM (IC50), CDK9-CyclinT1:2.7 μM (IC50)

化学信息

分子量	340.42
分子式	C₁₈H₂₄N₆O
CAS No.	189232-42-6
Smiles	CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCO)nc12
密度	1.27 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (146.88 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.88 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9375 mL	14.6877 mL	29.3755 mL	146.8774 mL
5 mM	0.5875 mL	2.9375 mL	5.8751 mL	29.3755 mL
10 mM	0.2938 mL	1.4688 mL	2.9375 mL	14.6877 mL
20 mM	0.1469 mL	0.7344 mL	1.4688 mL	7.3439 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	2.9375 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4688 mL