Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,580 | 现货 | ||
5 mg | ¥ 2,820 | 现货 | ||
10 mg | ¥ 4,560 | 现货 | ||
25 mg | ¥ 6,900 | 现货 | ||
50 mg | ¥ 9,490 | 现货 | ||
100 mg | ¥ 12,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,970 | 现货 |
产品描述 | NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively. |
体外活性 | NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1]. |
分子量 | 337.3 |
分子式 | C18H12FN3O3 |
CAS No. | 714240-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.3 mg/mL (18.7 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9647 mL | 14.8236 mL | 29.6472 mL | 74.118 mL |
5 mM | 0.5929 mL | 2.9647 mL | 5.9294 mL | 14.8236 mL | |
10 mM | 0.2965 mL | 1.4824 mL | 2.9647 mL | 7.4118 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NCGC00029283 714240-31-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis NCGC 00029283 NCGC-00029283 Inhibitor inhibitor inhibit