规格

价格

库存

数量

1 mg

¥ 282

现货

2 mg

¥ 395

现货

5 mg

¥ 663

现货

10 mg

¥ 997

现货

25 mg

¥ 1,880

现货

50 mg

¥ 3,320

现货

100 mg

¥ 4,880

现货

500 mg

¥ 9,870

现货

1 mL x 10 mM (in DMSO)

¥ 728

现货

生物活性

产品描述	FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
靶点活性	Notch:2.3 μM(EC50)
体外活性	在斑马鱼胚胎中,FLI-06（50uM）可使内源性的Notch信号被抑制.
体内活性	在肾上皮细胞系293细胞中,稳定转染突变型的APP可产生大量的淀粉样沉淀。FLI-06可使APP的成熟模式改变,从而终止APPs的释放。在过表达Notch绿色荧光蛋白的Hela细胞中,FLI-06抑制Notch的转运和进程。FLI-06可破坏高尔基复合体,在内质网从管状转换到片状形态的过程中,使内质网转运前总蛋白的分泌受到抑制。
激酶实验	EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1].
别名	FLI 06

化学信息

分子量	438.52
分子式	C₂₅H₃₀N₂O₅
CAS No.	313967-18-9
Smiles	CC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c1ccc(cc1)[N+]([O-])=O)C(=O)OC1CCCCC1
密度	1.25 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 8.8 mg/mL (20.07 mM), Sonication is recommended.

DMSO: 60 mg/mL (136.82 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 2.5 mg/mL (5.7 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO