Fomepizole

Name: Fomepizole
Brand: TargetMol
SKU: T0765
Price: 167 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T0765Cas号 7554-65-6

别名 甲吡唑, Antizol-Vet, Antizol, 4-甲基吡唑, 4-Methylpyrazole

Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。

Fomepizole

一键复制产品信息

很棒

纯度: 99.94%

货号 T0765 别名 甲吡唑, Antizol-Vet, Antizol, 4-甲基吡唑, 4-MethylpyrazoleCas号 7554-65-6

规格	价格	库存
100 mg	¥ 167	现货
500 mg	¥ 350	现货
1 g	¥ 493	现货
1 mL x 10 mM (in DMSO)	¥ 418	现货

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产品介绍

Fomepizole AI Summary

Fomepizole has inhibitory activity against horse liver alcohol dehydrogenase with a Ki value of 141.25 nM and a Kd value of 13.0 nM. Its partition coefficient (logP) is 0.96. This compound exhibits bioactivity in multiple assays, including inhibition of GCN5L2, Histone Lysine Methyltransferase G9a, T. brucei phosphofructokinase, and Marburg Virus entry, showing nanomolar potency in these bioassays. However, it has minimal hepatic side effects, with HepSE scores for various liver-related conditions all reporting 0.0, indicating no bioactivity in causing liver injury or dysfunction according to the DILIps training set data. Despite showing some antiviral activity against SARS-CoV-2 in VERO-6 cells with an IC50 value greater than 20,000.0 nM, it demonstrates low bioactivity in inhibiting cell viability of Vero E6 cells infected with SARS-CoV-2 and moderate activity in HRCE cells against the USA-WA1/2020 strain. The compound also shows 11.82% inhibition of SARS-CoV-2 3CL-Pro protease at a 20 µM concentration. Moreover, it impacts various biomarkers such as ALT, AST, BUN, and others, suggesting potential hepatotoxic, nephrotoxic, and hematotoxic effects. Despite binding affinities towards several receptors like Grin1, ADRB2, CHRNA4, OPRK1, and HTR2C with AC50 values greater than 10,000 nM, it has not shown significant inhibition or agonist activity in most assays conducted..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
别名	甲吡唑, Antizol-Vet, Antizol, 4-甲基吡唑, 4-Methylpyrazole

化学信息

分子量	82.1
分子式	C₄H₆N₂
CAS No.	7554-65-6
Smiles	CC1=CNN=C1
密度	1.015 g/cm3. Temperature:20 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 100 mg/mL (1218.03 mM), Sonication is recommended.

DMSO: 250 mg/mL (3045.07 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (24.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	12.1803 mL	60.9013 mL	121.8027 mL	609.0134 mL
5 mM	2.4361 mL	12.1803 mL	24.3605 mL	121.8027 mL
10 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
20 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
50 mM	0.2436 mL	1.2180 mL	2.4361 mL	12.1803 mL
100 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL