购物车

您的购物车当前为空

前往下单页继续购物

Fendiline hydrochloride

Name: Fendiline hydrochloride
Brand: TargetMol
SKU: T0327
Rating: 4.5 (1 reviews)

Synonyms: 盐酸芬他林, Fendiline HCl

货号 T0327Cas号 13636-18-5 一键复制产品信息纯度: 99.75%

很棒

Fendiline hydrochloride (Fendiline HCl) 是一种非选择性钙通道抑制剂。

Fendiline hydrochloride

一键复制产品信息

很棒

纯度: 99.75%

货号 T0327Cas号 13636-18-5

别名 盐酸芬他林, Fendiline HCl

Fendiline hydrochloride (Fendiline HCl) 是一种非选择性钙通道抑制剂。

规格	价格	库存
50 mg	¥ 236	待询
100 mg	¥ 413	待询
200 mg	¥ 588	待询
500 mg	¥ 980	待询
1 mL x 10 mM (in DMSO)	¥ 455	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.75%

颜色: 白色

性状: solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Fendiline hydrochloride AI Summary

Fendiline hydrochloride is a multi-target compound exhibiting bioactivity across various assays. It demonstrates potency in inhibiting dual action probes in a Huntington cell model, inducing genomic imprint erasure, and enhancing SMN2 splice variant expression. This compound modulates miRNAs, including miR-21, enhances lipid storage, and inhibits aldehyde dehydrogenase 1. Additionally, Fendiline hydrochloride inhibits 15-human lipoxygenase enzymes, Menin-MLL binding, and HP1-beta chromodomain interactions, while antagonizing the neuropeptide S receptor and activating Cytochrome P450 3A4. It also inhibits TGF-b, AmpC Beta-Lactamase, GPR55, histone lysine methyltransferase G9a, and Vif-A3F interactions, and induces DNA re-replication in various cell lines, showing synthetic lethality in tumor cells. Furthermore, it inhibits tyrosyl-DNA phosphodiesterases 1, exhibits gametocytocidal effects, and has a noteworthy inhibitory activity on sodium fluorescein uptake in OATP1B3 (114.64% inhibition) and OATP1B1 (90.27% inhibition) transfected CHO cells at a concentration of 10 μM. However, it showed lower efficacy in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of -0.1844 after 72 hours, compared to the arbidol control. These diverse activities indicate its potential across multiple biological pathways and disease targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.
别名	盐酸芬他林, Fendiline HCl

化学信息

分子量	351.91
分子式	C₂₃H₂₆ClN
CAS No.	13636-18-5
Smiles	Cl.CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1
密度	1.031g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 35.2 mg/mL (100.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8416 mL	14.2082 mL	28.4164 mL	142.0818 mL
5 mM	0.5683 mL	2.8416 mL	5.6833 mL	28.4164 mL
10 mM	0.2842 mL	1.4208 mL	2.8416 mL	14.2082 mL
20 mM	0.1421 mL	0.7104 mL	1.4208 mL	7.1041 mL
50 mM	0.0568 mL	0.2842 mL	0.5683 mL	2.8416 mL
100 mM	0.0284 mL	0.1421 mL	0.2842 mL	1.4208 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。