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别名 GBL-5g, 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂,可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性,具有化学保护和肝脏放射保护作用。


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UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂,可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性,具有化学保护和肝脏放射保护作用。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 223 | 现货 | |
| 5 mg | ¥ 536 | 现货 | |
| 10 mg | ¥ 833 | 现货 | |
| 25 mg | ¥ 1,430 | 现货 | |
| 50 mg | ¥ 2,030 | 现货 | |
| 100 mg | ¥ 2,860 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 846 | 现货 |
| 产品描述 | UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. It lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice, and acts as a novel chemo- and radioprotective agent. |
| 体内活性 | UTL-5g (GBL-5g) 通过降低由肺部照射引起的TGF-β 和TNF-α 水平[1]。 |
| 别名 | GBL-5g, 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- |
| 分子量 | 271.1 |
| 分子式 | C11H8Cl2N2O2 |
| CAS No. | 646530-37-2 |
| Smiles | Cc1cc(no1)C(=O)Nc1ccc(Cl)cc1Cl |
| 密度 | 1.469 g/cm3 (Predicted) |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 27.5 mg/mL (101.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+90% Corn Oil: 2 mg/mL (7.38 mM), Sonication is recommeded. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。 | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
对于不同动物的给药剂量换算,您也可以参考 更多