Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HSD1590 is a highly effective and potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.22 nM and 0.51 nM, respectively. It demonstrates exceptional binding affinity to ROCK, with Kd values below 2 nM. Moreover, HSD1590 showcases minimal cytotoxicity, making it an ideal compound for various applications.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,190 | 5日内发货 | ||
5 mg | ¥ 3,730 | 5日内发货 | ||
25 mg | ¥ 13,300 | 6-8周 | ||
50 mg | ¥ 17,400 | 6-8周 | ||
100 mg | ¥ 26,600 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,120 | 5日内发货 |
产品描述 | HSD1590 is a highly effective and potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.22 nM and 0.51 nM, respectively. It demonstrates exceptional binding affinity to ROCK, with Kd values below 2 nM. Moreover, HSD1590 showcases minimal cytotoxicity, making it an ideal compound for various applications. |
靶点活性 | ROCK1:1.22 nM (IC50), ROCK2:0.51 nM (IC50) |
体外活性 | HSD1590 (0.5-1 μM; 24 hours) exhibits an impressive attenuation in migration[1]. HSD1590 (0.5-10 μM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1]. Cell Viability Assay[1]Cell Line: MDA-MB-23 cells Concentration: 0.5-10 μM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h. |
分子量 | 359.19 |
分子式 | C20H18BN3O3 |
CAS No. | 2379279-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HSD1590 2379279-96-4 HSD 1590 HSD-1590 Inhibitor inhibitor inhibit