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顶部相关产品产品介绍化学信息储存和溶解信息TCMIP相关数据计算器

6',7'-Epoxybergamottin

货号 T37810Cas号 206978-14-5 一键复制产品信息
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6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.

6',7'-Epoxybergamottin

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货号 T37810Cas号 206978-14-5

6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.

6',7'-Epoxybergamottin
规格价格库存数量
1 mg
¥ 1,130
35日内发货
5 mg
¥ 4,290
35日内发货
10 mg
¥ 8,160
35日内发货
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产品介绍

生物活性
产品描述
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.
化学信息
分子量354.4
分子式C21H22O5
CAS No.206978-14-5
SmilesO(C/C=C(/CCC1C(C)(C)O1)\C)C=2C3=C(C=C4C2C=CO4)OC(=O)C=C3
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.41 mM), Sonication is recommended.
Ethanol: 10 mg/mL (28.22 mM), Sonication is recommended.
DMSO: 30 mg/mL (84.65 mM), Sonication is recommended.
DMF: 30 mg/mL (84.65 mM), Sonication is recommended.
溶液配制表
1mg5mg10mg50mg
1 mM2.8217 mL14.1084 mL28.2167 mL141.0835 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.5643 mL2.8217 mL5.6433 mL28.2167 mL
10 mM0.2822 mL1.4108 mL2.8217 mL14.1084 mL
20 mM0.1411 mL0.7054 mL1.4108 mL7.0542 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0564 mL0.2822 mL0.5643 mL2.8217 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

TCMIP相关数据

中药材来源及性味归经
中药材名称中药材拉丁名性味归经
代代花Citrus aurantium L.var.amara Engl.[C.aurantium ‘Daidai’]平辛, 甘, 微苦肝, 胃
酸橙Citrus aurantium L.寒酸
所属中成药
中成药名称处方组成中成药类型
小儿增食丸山楂,六神曲,麦芽,焦槟榔,黄芩,化橘红,砂仁,枳壳,代代花,鸡内金,莱菔子消食化积
肝郁调经膏白芍,佛手,郁金,玫瑰花,代代花,牡丹皮,川楝子,香附,当归,丹参,葛根,泽泻理气药

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

6',7'-Epoxybergamottin6',7'Epoxybergamottin6',7' Epoxybergamottin
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