MMRi64

Name: MMRi64
Brand: TargetMol
SKU: T28078
Price: 497 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T28078Cas号 430458-66-5

MMRi64 是 Mdm2-MdmX E3 连接酶活性的特异性抑制剂。MMRi64 能有效诱导 p53 积累，并诱导白血病/淋巴瘤细胞中 p53 途径的凋亡，破坏 Mdm2-MdmX 相互作用，下调白血病细胞中的 Mdm2 和 MdmX。MMRi64 MMRi64 可用于癌症研究。

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MMRi64

一键复制产品信息

很棒

纯度: 99.93%

货号 T28078Cas号 430458-66-5

规格	价格	库存
1 mg	¥ 497	现货
5 mg	¥ 1,230	现货
10 mg	¥ 1,920	现货
25 mg	¥ 3,380	现货
50 mg	¥ 4,820	现货
100 mg	¥ 6,680	现货
500 mg	¥ 13,300	现货

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COA HNMR LCMS 产品操作手册

产品介绍

MMRi64 AI Summary

MMRi64 demonstrates significant bioactivity, notably inhibiting the growth of Plasmodium falciparum in red blood cells with EC50 values of 144.1 nM and 152.2 nM for the W2 (drug-resistant) and 3D7 (drug-susceptible) strains, respectively. It shows varying degrees of efficacy against different P. falciparum strains, including K1 (EC50 = 1673.5 nM) and 3D7 (EC50 = 1497.9 nM). Additionally, it exhibits high Inhibition Frequency Index (IFI) of 7.692%. It also displays cytotoxicity in human HepG2 cells and significant inhibition (CC50 > 48960.0 nM) in the Huh7 hepatocellular carcinoma cell line. The compound further shows inhibition of Leishmania Mexicana promastigotes with variable effects depending on transporter protein expression. Moreover, MMRi64 inhibits the p53-MDM2 interaction with an IC50 value of 4400.0 nM. These bioactivities suggest that MMRi64 has potential as an antimalarial and anti-cancer agent, and it also may affect other parasitic diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

化学信息

分子量	410.3
分子式	C₂₂H₁₇Cl₂N₃O
CAS No.	430458-66-5
Smiles	C(NC1=CC(C)=CC=N1)(C2=C(O)C3=C(C=C2)C=CC=N3)C4=C(Cl)C(Cl)=CC=C4
密度	1.402 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (146.23 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.09 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4372 mL	12.1862 mL	24.3724 mL	121.8621 mL
5 mM	0.4874 mL	2.4372 mL	4.8745 mL	24.3724 mL
10 mM	0.2437 mL	1.2186 mL	2.4372 mL	12.1862 mL
20 mM	0.1219 mL	0.6093 mL	1.2186 mL	6.0931 mL
50 mM	0.0487 mL	0.2437 mL	0.4874 mL	2.4372 mL
100 mM	0.0244 mL	0.1219 mL	0.2437 mL	1.2186 mL