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Sulfamethoxazole

Name: Sulfamethoxazole
Brand: TargetMol
SKU: T0885
Price: 158 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T0885Cas号 723-46-6

别名 磺胺甲恶唑, STX 608, Ro 4-2130

Sulfamethoxazole (STX 608) 是磺胺类抗菌素，用于细菌感染。Sulfonamides 是对氨基苯甲酸的竞争性拮抗剂。

Sulfamethoxazole

一键复制产品信息

很棒

纯度: 99.92%

货号 T0885 别名 磺胺甲恶唑, STX 608, Ro 4-2130Cas号 723-46-6

Sulfamethoxazole (STX 608) 是磺胺类抗菌素，用于细菌感染。Sulfonamides 是对氨基苯甲酸的竞争性拮抗剂。

规格	价格	库存
50 mg	¥ 158	现货
100 mg	¥ 205	现货
200 mg	¥ 287	现货
1 mL x 10 mM (in DMSO)	¥ 320	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 99.92%

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COA HNMR LCMS 产品操作手册

产品介绍

Sulfamethoxazole AI Summary

Sulfamethoxazole exhibits a broad spectrum of bioactivities including antimicrobial, antiviral, and enzyme inhibition properties. This compound demonstrates potent antibacterial activity against various bacterial strains such as Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa with Minimum Inhibitory Concentration (MIC) values ranging from 1.0 to 256.0 µg/mL. It also shows potential in treating Candida albicans infections in immunosuppressed mice, evidenced by reduced tissue colony formation units (cfu) in the brain and kidney. Additionally, Sulfamethoxazole inhibits key enzymes such as dihydrofolate reductase in Pneumocystis carinii and dihydropteroate synthase in Escherichia coli, with IC50 values of 100.0 nM and 4700.0 nM, respectively. Its antiviral activity includes inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, showing moderate potency with IC50 values around 10 µM. Pharmacokinetic properties of Sulfamethoxazole are notable, with high oral bioavailability (F ≥ 80%) and a volume of distribution of 0.3 L.kg-1. It also exhibits different plasma protein binding affinities in human (57%) and CD-1 mouse plasma (9%). Moreover, Sulfamethoxazole acts as an inhibitor for human immunodeficiency virus type 1 protease (Kd = 577.0 nM, Ki = 10.1 nM) and shows time-dependent inhibition of several human CYP enzymes, implicating its interaction with drug metabolism pathways. However, there is some evidence of potential drug-induced liver injury (DILI) based on various liver toxicity assays. In conclusion, Sulfamethoxazole presents itself as a versatile compound with significant antimicrobial and antiviral activities, as well as inhibitory effects on enzymatic functions, making it a potential candidate for further therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfamethoxazole (STX 608) is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification of sulfamethoxazole is Sulfonamides.
别名	磺胺甲恶唑, STX 608, Ro 4-2130

化学信息

分子量	253.28
分子式	C₁₀H₁₁N₃O₃S
CAS No.	723-46-6
Smiles	CC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
密度	1.462 g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 255 mg/mL (1006.79 mM), Sonication is recommended.

Ethanol: 22 mg/mL (86.86 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.9 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9482 mL	19.7410 mL	39.4820 mL	197.4100 mL
5 mM	0.7896 mL	3.9482 mL	7.8964 mL	39.4820 mL
10 mM	0.3948 mL	1.9741 mL	3.9482 mL	19.7410 mL
20 mM	0.1974 mL	0.9870 mL	1.9741 mL	9.8705 mL
50 mM	0.0790 mL	0.3948 mL	0.7896 mL	3.9482 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0395 mL	0.1974 mL	0.3948 mL	1.9741 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Sulfamethoxazole STX-608 STX608 Inhibitor inhibit DHPS Bacterial Antibiotic

Sulfamethoxazole

Sulfamethoxazole