Faropenem daloxate

Name: Faropenem daloxate
Brand: TargetMol
SKU: T11265
Price: 1070 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T11265Cas号 141702-36-5

别名 法罗培南酯, Faropenem medoxil

Faropenem daloxate (Faropenem medoxil) 是β-内酰胺类口服抗生素。

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Faropenem daloxate

一键复制产品信息

很棒

货号 T11265 别名 法罗培南酯, Faropenem medoxilCas号 141702-36-5

Faropenem daloxate (Faropenem medoxil) 是β-内酰胺类口服抗生素。

规格	价格	库存
1 mg	¥ 313	现货
5 mg	¥ 689	现货
10 mg	¥ 1,070	现货
25 mg	待询	现货
50 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 615	现货

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产品介绍

Faropenem daloxate AI Summary

Faropenem daloxate exhibits antibacterial activity against beta-lactamase-producing Bacillus anthracis strains with varying minimum inhibitory concentrations (MIC). It shows efficacy in Bacillus anthracis-infected BALB/c mouse models with different dosages and intervals post-infection, and demonstrates plasma protein binding in mouse and human models, along with key pharmacokinetic parameters such as clearance, half-life, and peak plasma concentration. Additionally, it displays antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, showing respective inhibitions of 3.56% and -0.1%. The compound has a hit score of 0.000691 against the SARS-CoV-2 USA-WA1/2020 strain in HRCE cells and inhibits SARS-CoV-2 3CL-Pro protease by 4.389% at 20 µM. Furthermore, Faropenem daloxate inhibits human HDAC6, with 31.1% inhibition using a commercial peptide substrate and -7.21% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated in acute bacterial rhinosinusitis.Faropenem daloxate is the first oral penem in a new class of beta-lactam antibiotics.
别名	法罗培南酯, Faropenem medoxil

化学信息

分子量	397.4
分子式	C₁₇H₁₉NO₈S
CAS No.	141702-36-5
Smiles	[H][C@]12SC([C@H]3CCCO3)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(=O)OCc1oc(=O)oc1C
密度	1.55 g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: ≥ 100 mg/mL (251.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5164 mL	12.5818 mL	25.1636 mL	125.8178 mL
5 mM	0.5033 mL	2.5164 mL	5.0327 mL	25.1636 mL
10 mM	0.2516 mL	1.2582 mL	2.5164 mL	12.5818 mL
20 mM	0.1258 mL	0.6291 mL	1.2582 mL	6.2909 mL
50 mM	0.0503 mL	0.2516 mL	0.5033 mL	2.5164 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2582 mL