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TNO155

Name: TNO155
Brand: TargetMol
SKU: T13176
Price: 622 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.63%

货号 T13176Cas号 1801765-04-7

别名 Batoprotafib

TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。

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TNO155

一键复制产品信息

很棒

纯度: 99.63%

货号 T13176 别名 BatoprotafibCas号 1801765-04-7

TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。

规格	价格	库存
1 mg	¥ 622	现货
5 mg	¥ 1,690	现货
10 mg	¥ 2,520	现货
25 mg	¥ 4,160	现货
50 mg	¥ 5,790	现货
100 mg	¥ 7,800	现货
200 mg	¥ 10,300	现货
1 mL x 10 mM (in DMSO)	¥ 1,870	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: >99.99%

颜色: 白色至黄色

性状: Solid

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COA HNMR 产品操作手册

产品介绍

TNO155 AI Summary

TNO155 displays a range of bioactivities, including notable allosteric inhibition of the SHP2 enzyme, with an IC50 of 11.0 nM in both 6x-histidine tagged human SHP2 expressed in E. coli and human KYSE-520 cells, where it reduces ERK1/2 phosphorylation. It demonstrates significant antiproliferative activity against various cancer cells, such as human KYSE-520 cells (IC50 = 100.0 nM), and human breast cancer cells MDA-MB-231 and MDA-MB-468, leading to cell cycle arrest and apoptosis particularly in MDA-MB-231 cells during different phases, most notably the S phase. Moreover, it exhibits antitumor activity in a mouse model against EMT6 cells, showing significant tumor growth inhibition. However, the compound also presents toxicity under irradiation in mouse 3T3 cells (IC50 = 666000.0 nM) and varied effects on cell viability across different cell types. In HEK293T and U2OS cells, it alters growth rates variably, enhancing growth consistently in U2OS cells while having mixed stimulating and inhibitory effects on human fibroblasts. Thermal shift assays reveal that TNO155 affects the stability of different protein domains, both decreasing and increasing thermal stability, suggesting potential domain-specific impacts on protein structure and function. Overall, these bioactivities highlight TNO155's potential as an anti-cancer agent with significant enzyme inhibition properties, albeit with consideration of its cell-type-specific effects and toxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.
靶点活性	SHP2:0.011 µM
别名	Batoprotafib

化学信息

分子量	421.95
分子式	C₁₈H₂₄ClN₇OS
CAS No.	1801765-04-7
Smiles	C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N
密度	1.47 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (118.5 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3699 mL	11.8497 mL	23.6995 mL	118.4975 mL
5 mM	0.4740 mL	2.3699 mL	4.7399 mL	23.6995 mL
10 mM	0.2370 mL	1.1850 mL	2.3699 mL	11.8497 mL
20 mM	0.1185 mL	0.5925 mL	1.1850 mL	5.9249 mL
50 mM	0.0474 mL	0.2370 mL	0.4740 mL	2.3699 mL
100 mM	0.0237 mL	0.1185 mL	0.2370 mL	1.1850 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。