Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli[2].

Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency[2].