Pyraclostrobin

Name: Pyraclostrobin
Brand: TargetMol
SKU: T9491
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T9491Cas号 175013-18-0

别名 吡唑醚菌酯

Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。

Pyraclostrobin

一键复制产品信息

很棒

纯度: 99.89%

货号 T9491 别名 吡唑醚菌酯Cas号 175013-18-0

Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。

规格	价格	库存
25 mg	¥ 132	现货
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 745	现货
1 g	¥ 1,090	待询
1 mL x 10 mM (in DMSO)	¥ 272	现货

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纯度: 99.89%

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产品介绍

Pyraclostrobin AI Summary

Pyraclostrobin demonstrates significant bioactivity as an inhibitor of the Chagas Disease parasite Trypanosoma cruzi in vitro, with an IC50 value of 6460 nM and cytotoxicity against L-6 rat myoblasts with an IC50 value of 43360 nM. It exhibits multiple bioactivities, acting as an agonist of estrogen receptor alpha (158.5 nM) and androgen receptor signaling (1778.3 nM), an antagonist of thyroid hormone receptor beta (6309.6 nM) and farnesoid X receptor signaling (4466.8 nM), and functions as both an agonist and antagonist of peroxisome proliferator-activated receptor delta signaling with differing potencies (6309.6 nM and 2511.9 nM, respectively). It also serves as an antagonist of retinoid X receptor alpha (3162.3 nM) and activates the nuclear factor-kappa B (NF-kB) and p53 signaling pathways (39810.7 nM and 5011.9 nM respectively), among other signaling pathways. Additionally, Pyraclostrobin has demonstrated broad antifungal activity against various fungal pathogens, including Rhizoctonia solani, Pythium ultimum, Pestalotiopsis microspora, Monilinia laxa, Pyrenophora tritici-repentis, Botryotinia fuckeliana, Fusarium graminearum, and multiple other fungal isolates. It shows low EC50 values, indicating potent inhibition of mycelial growth, conidium germination, and overcoming resistance in mutant strains. Furthermore, it effectively inhibits heart cytochrome bc1 complex in Sus scrofa with a Ki of 3.3 nM. Overall, Pyraclostrobin exhibits immense potential as an antifungal agent and bioactivity modulator in various biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.
别名	吡唑醚菌酯

化学信息

分子量	387.82
分子式	C₁₉H₁₈ClN₃O₄
CAS No.	175013-18-0
Smiles	N(C(OC)=O)(OC)C1=C(COC2=NN(C=C2)C3=CC=C(Cl)C=C3)C=CC=C1
密度	1.27 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (644.63 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5785 mL	12.8926 mL	25.7852 mL	128.9258 mL
5 mM	0.5157 mL	2.5785 mL	5.1570 mL	25.7852 mL
10 mM	0.2579 mL	1.2893 mL	2.5785 mL	12.8926 mL
20 mM	0.1289 mL	0.6446 mL	1.2893 mL	6.4463 mL
50 mM	0.0516 mL	0.2579 mL	0.5157 mL	2.5785 mL
100 mM	0.0258 mL	0.1289 mL	0.2579 mL	1.2893 mL