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Thiolutin

Name: Thiolutin
Brand: TargetMol
SKU: T67708
Price: 1220 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T67708Cas号 87-11-6

别名 硫藤黄素, Acetopyrrothin

Thiolutin (Acetopyrrothin) 是一种内皮细胞粘附抑制剂，由链霉菌产生。 Thiolutin 具有抗生素和抗血管生成特性。 Thiolutin 可快速诱导 Hsp27 的磷酸化。

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Thiolutin

一键复制产品信息

很棒

纯度: 99.93%

货号 T67708 别名 硫藤黄素, AcetopyrrothinCas号 87-11-6

Thiolutin (Acetopyrrothin) 是一种内皮细胞粘附抑制剂，由链霉菌产生。 Thiolutin 具有抗生素和抗血管生成特性。 Thiolutin 可快速诱导 Hsp27 的磷酸化。

规格	价格	库存
1 mg	¥ 1,220	现货
5 mg	¥ 2,970	现货
10 mg	¥ 4,890	现货
25 mg	¥ 7,490	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,600	现货
1 mL x 10 mM (in DMSO)	¥ 3,380	现货

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COA LCMS HNMR 产品操作手册

产品介绍

Thiolutin AI Summary

Thiolutin exhibits broad-spectrum bioactivity, including significant antimicrobial and antifungal effects. It demonstrates antimicrobial activity against Staphylococcus epidermidis with a MIC of 6.25 µg/mL and an MBC of 12.5 µg/mL, indicating a moderate bactericidal effect with an MBC/MIC ratio of 2.0. Additionally, it shows RNA polymerase-mediated transcription inhibition in Staphylococcus epidermidis with an IC50 greater than 100.0 µg/mL. In antifungal assays, Thiolutin reveals specific efficacy against yeast strains expressing Candida albicans CaMdr1p with a 7.0 mm inhibition zone, while showing no inhibition against CaCdr1p. Beyond these, Thiolutin is effective across a variety of bioactivities such as inducing the erasure of genomic imprints, inhibiting tau fibril formation, inhibiting ROR gamma transcriptional activity, inhibiting the phosphopantetheinyl transferase Sfp in Bacillus subtilis, and disrupting the CBF-beta and RUNX1 interaction for treating Acute Myeloid Leukemia. Moreover, it demonstrates growth inhibition against diverse human tumor cell lines originating from renal, breast, lung, leukemia, prostate, melanoma, ovarian, and central nervous system tissues..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
别名	硫藤黄素, Acetopyrrothin

化学信息

分子量	228.29
分子式	C₈H₈N₂O₂S₂
CAS No.	87-11-6
Smiles	CC(=O)Nc1c2sscc2n(C)c1=O

储存&溶解度

存储

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 4.5 mg/mL (19.71 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3804 mL	21.9020 mL	43.8039 mL	219.0197 mL
5 mM	0.8761 mL	4.3804 mL	8.7608 mL	43.8039 mL
10 mM	0.4380 mL	2.1902 mL	4.3804 mL	21.9020 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。