BMS-488043

Name: BMS-488043
Brand: TargetMol
SKU: T30527
Price: 970 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.95%

货号 T30527Cas号 452296-83-2

别名 UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043

BMS-488043 是一种新颖独特的口服小分子HIV融合抑制剂，可抑制人类免疫缺陷病毒 1 型（HIV-1）附着于 CD4（+）淋巴细胞。BMS-488043 可用于治疗免疫系统疾病、感染和泌尿生殖系统疾病，可用与研究HIV感染。

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BMS-488043

一键复制产品信息

很棒

纯度: 99.95%

货号 T30527 别名 UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043Cas号 452296-83-2

规格	价格	库存
1 mg	¥ 970	现货
5 mg	¥ 2,390	现货
10 mg	¥ 3,560	现货
25 mg	¥ 5,760	现货
50 mg	¥ 7,860	现货
100 mg	¥ 10,800	现货
500 mg	¥ 21,600	现货

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产品介绍

BMS-488043 AI Summary

BMS-488043 exhibits potent antiviral activity against various strains of HIV-1, including both R5-tropic and X4-tropic strains, with IC50 values as low as 0.88 nM and EC50 values ranging from 0.8 nM to 7131.0 nM. It shows effective inhibition of HIV-1 gp120/CD4 interactions, with an IC50 of 25.82 nM, and demonstrates protection against viral envelope infection in human cells. The compound also has low cytotoxicity in different cell lines, such as human U87 and HeLa cells, with CC50 values exceeding 40,000.0 nM to 300,000.0 nM. Pharmacokinetic studies reveal that BMS-488043 has high oral bioavailability in rats (90%), moderate oral bioavailability in dogs (57%), and monkeys (60%). It exhibits favorable pharmacokinetic properties including a high AUC of 2661.37 ng.hr.mL-1 and a Cmax of 1889.0 nM at a 5 mg/kg oral dose in rats. The compound also shows good permeability in human Caco-2 cells, low clearance rates of 13.0 mL/min/kg in rats, significant aqueous solubility in various pH buffer solutions, and reasonable metabolic stability in human liver microsomes with a half-life greater than 100.0 hours. In high-fat fed healthy humans, it achieves a plasma concentration (Cmax) of 9705.52 nM and an AUC of 21191.0 ng.hr.mL-1 after 800 mg oral administration, with a half-life of 14.0 hours. Overall, BMS-488043's potent antiviral efficacy, low cytotoxicity, and favorable pharmacokinetic profile make it a promising candidate for further development in antiviral drug research..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) lymphocytes.BMS-488043 is used for the treatment of immune disorders, infections, and genitourinary disorders, and can be used in the study of HIV infect
别名	UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043

化学信息

分子量	422.43
分子式	C₂₂H₂₂N₄O₅
CAS No.	452296-83-2
Smiles	C(C(=O)N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C=3C=4C(=C(OC)N=CC4OC)NC3
密度	1.363 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (118.36 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3673 mL	11.8363 mL	23.6726 mL	118.3628 mL
5 mM	0.4735 mL	2.3673 mL	4.7345 mL	23.6726 mL
10 mM	0.2367 mL	1.1836 mL	2.3673 mL	11.8363 mL
20 mM	0.1184 mL	0.5918 mL	1.1836 mL	5.9181 mL
50 mM	0.0473 mL	0.2367 mL	0.4735 mL	2.3673 mL
100 mM	0.0237 mL	0.1184 mL	0.2367 mL	1.1836 mL