Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thiodigalactoside 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 109 | 现货 | ||
5 mg | ¥ 222 | 现货 | ||
10 mg | ¥ 313 | 现货 | ||
25 mg | ¥ 463 | 现货 | ||
50 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 263 | 现货 |
产品描述 | Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats. |
靶点活性 | GAL3:49 μM (Kd), GAL1:24 μM (Kd) |
体外活性 | Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining[1]. |
体内活性 | Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2]. |
分子量 | 358.36 |
分子式 | C12H22O10S |
CAS No. | 51555-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 10 mg/mL
H2O: 90mg/mL (251.1mM), sonification is recommended.
DMF: 1 mg/mL
DMSO: 20 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.7905 mL | 13.9525 mL | 27.9049 mL | 69.7623 mL |
5 mM | 0.5581 mL | 2.7905 mL | 5.581 mL | 13.9525 mL | |
10 mM | 0.279 mL | 1.3952 mL | 2.7905 mL | 6.9762 mL | |
20 mM | 0.1395 mL | 0.6976 mL | 1.3952 mL | 3.4881 mL | |
50 mM | 0.0558 mL | 0.279 mL | 0.5581 mL | 1.3952 mL | |
100 mM | 0.0279 mL | 0.1395 mL | 0.279 mL | 0.6976 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Thiodigalactoside 51555-87-4 Immunology/Inflammation Galectin Inhibitor inhibitor inhibit