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AS 1892802

Name: AS 1892802
Brand: TargetMol
SKU: T22037
Price: 428 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T22037Cas号 928320-12-1 一键复制产品信息纯度: 99.86%

很棒

AS 1892802是一种强效和选择性的ROCK 抑制剂。AS 1892802 用于人ROCK2、大鼠ROCK2和人ROCK1的 IC50值分别为52nM、57nM 和122nM。AS 1892802的镇痛作用起效速度与曲马多和双氯芬酸的起效速度一样快。

AS 1892802

一键复制产品信息

很棒

纯度: 99.86%

货号 T22037Cas号 928320-12-1

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 428	现货
5 mg	¥ 1,070	现货
10 mg	¥ 1,820	现货
25 mg	¥ 3,950	现货
50 mg	¥ 5,630	现货
100 mg	¥ 7,680	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 789	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.86%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

AS 1892802 AI Summary

AS 1892802 exhibits potent bioactivity by inhibiting ROCK2 with an IC50 of 100.0 nM and ROCK1 with an IC50 of 1690.0 nM, demonstrating higher potency against ROCK2 compared to ROCK1. Determined through FRET-based enzyme-coupled assays, the compound's effectiveness is observed via the phosphorylation levels of peptide substrates. Additionally, AS 1892802 displays antiviral activity, reducing SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 1.86% at 10 µM after 48 hours and inhibiting SARS-CoV-2 3CL-Pro protease by 37.01% at 20 µM. Furthermore, the compound impacts human HDAC6 enzyme activity, noted with -20.1% inhibition in enzymatic assays using a commercial peptide substrate and -2.05% with a custom peptide substrate, indicating its potential HDAC6 inhibitory bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 is as fast as those of Tramadol and Diclofenac.
靶点活性	ROCK2 (rat):52nM, ROCK2 (huamn):52 nM

化学信息

分子量	333.38
分子式	C₂₀H₁₉N₃O₂
CAS No.	928320-12-1
Smiles	N(C(N[C@H](CO)C1=CC=CC=C1)=O)C2=CC=C(C=C2)C=3C=CN=CC3
密度	1.256 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: 7.5 mg/mL (22.5 mM), Sonication is recommended.

DMSO: 40 mg/mL (119.98 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9996 mL	14.9979 mL	29.9958 mL	149.9790 mL
5 mM	0.5999 mL	2.9996 mL	5.9992 mL	29.9958 mL
10 mM	0.3000 mL	1.4998 mL	2.9996 mL	14.9979 mL
20 mM	0.1500 mL	0.7499 mL	1.4998 mL	7.4990 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0600 mL	0.3000 mL	0.5999 mL	2.9996 mL
100 mM	0.0300 mL	0.1500 mL	0.3000 mL	1.4998 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。