store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LSD1-IN-24 是一种具有选择性和有效性的 LSD1 抑制剂,IC50 值为 0.247 μM。LSD1-IN-24 可诱导 PD-L1 的表达,加强 T 细胞杀伤反应,可用于癌症相关疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 497 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,960 | 现货 | ||
50 mg | ¥ 6,470 | 现货 | ||
100 mg | ¥ 8,720 | 现货 | ||
500 mg | ¥ 17,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,360 | 现货 |
产品描述 | LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases. |
体外活性 | LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3[1]. |
体内活性 | In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice[1]. |
分子量 | 312.43 |
分子式 | C18H20N2OS |
CAS No. | 4734-59-2 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (160.04 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2007 mL | 16.0036 mL | 32.0072 mL | 80.0179 mL |
5 mM | 0.6401 mL | 3.2007 mL | 6.4014 mL | 16.0036 mL | |
10 mM | 0.3201 mL | 1.6004 mL | 3.2007 mL | 8.0018 mL | |
20 mM | 0.16 mL | 0.8002 mL | 1.6004 mL | 4.0009 mL | |
50 mM | 0.064 mL | 0.3201 mL | 0.6401 mL | 1.6004 mL | |
100 mM | 0.032 mL | 0.16 mL | 0.3201 mL | 0.8002 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LSD1-IN-24 4734-59-2 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic Immunology/Inflammation Histone Demethylase PD-1/PD-L1 LSD1IN24 Inhibitor inhibitor inhibit