Name: Pironetin
Brand: TargetMol
SKU: T16543
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 20,500

3-6月

50 mg

¥ 27,300

3-6月

100 mg

¥ 35,500

3-6月

生物活性

产品描述	Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.
体外活性	Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780, and K-NRK cells) treatment suppresses cell proliferation. Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells. The IC50 values against these cell lines are almost 10 ng/mL[1].
体内活性	Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment displays a moderate antitumor effect. However, a severe weight loss is observed as a side effect[1].

化学信息

分子量	324.45
分子式	C₁₉H₃₂O₄
CAS No.	151519-02-7
Smiles	C([C@H]([C@@H]([C@@H]([C@H](C/C=C/C)C)OC)C)O)[C@@H]1[C@H](CC)C=CC(=O)O1
密度	0.993 g/cm3 (Predicted)