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Isosorbide Mononitrate

Name: Isosorbide Mononitrate
Brand: TargetMol
SKU: T6863
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.16%

货号 T6863Cas号 16051-77-7

别名 单硝酸异山梨酯, Mononit, Monoket, Isosorbide-5-mononitrate, Imdur, Elantan, Corangin, 5-单硝酸异山梨酯

Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂，扩张血管从而降低血压，可用于心绞痛。

Isosorbide Mononitrate

一键复制产品信息

很棒

纯度: 98.16%

货号 T6863 别名 单硝酸异山梨酯, Mononit, Monoket, Isosorbide-5-mononitrate, Imdur, Elantan, Corangin, 5-单硝酸异山梨酯Cas号 16051-77-7

Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂，扩张血管从而降低血压，可用于心绞痛。

规格	价格	库存
100 mg	¥ 137	现货
500 mg	¥ 289	待询
1 g	¥ 372	待询
1 mL x 10 mM (in DMSO)	¥ 318	现货

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纯度: 98.16%

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COA HNMR LCMS 产品操作手册

产品介绍

Isosorbide Mononitrate AI Summary

Isosorbide Mononitrate demonstrates a diverse range of bioactivities and favorable pharmacokinetic properties, making it a potential candidate for therapeutic applications. Notably, the compound exhibits significant cardiovascular effects, such as reducing T-wave increases in rats, decreasing arterial medium pressure in rabbits by 30 mm Hg, and showing vasodilation activity in rabbit aortic rings with an EC50 of 9600.0 nM. In terms of pharmacokinetics, it has a high clearance rate in various species, including humans, with a total body clearance of 2.0 mL/min/kg and moderate renal clearance. It is absorbed well with a high fraction unbound in the plasma, indicating good availability for target interaction. The compound also shows substantial antiviral activities, including the inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 and Caco-2 cells. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 17.33% at 20 µM and demonstrates moderate effectiveness in reducing ocular hypertension in rabbits. Moreover, Isosorbide Mononitrate interacts with liver enzymes, causing significant increases in activities like alkaline phosphatase and lactate dehydrogenase, indicating potential hepatic side effects. Lastly, it showcases a notable inhibition of HDAC6 enzyme activity, revealing potential in epigenetic modulation. Overall, Isosorbide Mononitrate presents itself as a multifunctional molecule with promising therapeutic potential, especially for cardiovascular ailments, antiviral applications, and possibly epigenetic therapies, despite some indications of hepatic side effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.
别名	单硝酸异山梨酯, Mononit, Monoket, Isosorbide-5-mononitrate, Imdur, Elantan, Corangin, 5-单硝酸异山梨酯

化学信息

分子量	191.14
分子式	C₆H₉NO₆
CAS No.	16051-77-7
Smiles	[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O
密度	1.56g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 35 mg/mL (183.11 mM), Sonication is recommended.

Ethanol: 36 mg/mL (188.34 mM), Sonication is recommended.

DMSO: 50 mg/mL (261.59 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2318 mL	26.1588 mL	52.3177 mL	261.5884 mL
5 mM	1.0464 mL	5.2318 mL	10.4635 mL	52.3177 mL
10 mM	0.5232 mL	2.6159 mL	5.2318 mL	26.1588 mL
20 mM	0.2616 mL	1.3079 mL	2.6159 mL	13.0794 mL
50 mM	0.1046 mL	0.5232 mL	1.0464 mL	5.2318 mL
100 mM	0.0523 mL	0.2616 mL	0.5232 mL	2.6159 mL