Piperonyl butoxide

Name: Piperonyl butoxide
Brand: TargetMol
SKU: T0727
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T0727Cas号 51-03-6

别名 增效醚, Pyrenone 606, Ethanol butoxide, ENT-14250, Butacide

Piperonyl butoxide (Pyrenone 606) 是黄樟素的半合成衍生物, 用作农药制剂的一个组成部分, 它是杀虫剂增效剂。

Piperonyl butoxide

一键复制产品信息

很棒

纯度: 99.84%

货号 T0727 别名 增效醚, Pyrenone 606, Ethanol butoxide, ENT-14250, ButacideCas号 51-03-6

Piperonyl butoxide (Pyrenone 606) 是黄樟素的半合成衍生物, 用作农药制剂的一个组成部分, 它是杀虫剂增效剂。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 198	现货
100 mg	¥ 289	现货
200 mg	¥ 397	现货
500 mg	¥ 662	现货
1 g	¥ 973	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

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产品介绍

Piperonyl butoxide AI Summary

Piperonyl butoxide exhibits a diverse range of bioactivities. It acts as an agonist on the Thyroid Stimulating Hormone Receptor and as an antagonist of the peroxisome proliferator-activated receptor delta signaling. Additionally, it inhibits enzymes such as Aldehyde Dehydrogenase 1 (ALDH1A1), human tyrosyl-DNA phosphodiesterase 1 (TDP1), and the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. Notably, it influences the Cytochrome P450 3A4 enzyme as both an activator and inhibitor/substrate and demonstrates activating effects on both rat and human pregnane X receptor (PXR) signaling pathways. Piperonyl butoxide also blocks the entry of the Ebola virus and shows gametocytocidal activity. In agricultural contexts, Piperonyl butoxide exhibits insecticidal properties. Against Frankliniella occidentalis (western flower thrips), it gave a 10.0% mortality rate at a concentration of 1000 mg/l and inhibits total esterase activity with IC50 values between 1910000.0 nM and 2670000.0 nM. It also inhibits B-type Bemisia tabaci (sweet potato whitefly) enzyme activity, showing significant reduction in oxidase-mediated O-deethylation and esterase activity. For Tetranychus urticae (two-spotted spider mite) larvae, it increases mortality rates, especially when combined with spirodiclofen and cytochrome P450 monooxygenase inhibitor, PBO. Additionally, in Wistar rat liver microsomes, it inhibits both aniline hydroxylase and aminopyrine demethylase activities with an IC50 value of 420,000.0 nM. As a CYP3A4 enzyme inhibitor relevant to retinoic acid metabolism, it has an IC50 value of 3000.0 nM, suggesting potential as a Retinoic Acid Metabolism Blocking Agent (RAMBA). For its impact on human BSEP (Bile Salt Export Pump) activity, Piperonyl butoxide shows an IC50 value of less than 10,000.0 nM in baculovirus transfected cell membranes. It demonstrates antiviral capabilities against SARS-CoV-2 (strain BavPat1) with an inhibition index of 0.8723 in infected Vero E6 cells and a hit score of 0.1894 in HRCE cells for the USA-WA1/2020 strain, though its efficacy is less compared to controls like arbidol..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Piperonyl butoxide (Pyrenone 606) is an insecticide synergist, particularly for rotenone and pyrethroids.
别名	增效醚, Pyrenone 606, Ethanol butoxide, ENT-14250, Butacide

化学信息

分子量	338.44
分子式	C₁₉H₃₀O₅
CAS No.	51-03-6
Smiles	C(OCCOCCOCCCC)C=1C=C2C(=CC1CCC)OCO2
密度	0.001 g/L. Temperature:20 °C.
颜色	Transparent
物理性状	Liquid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (147.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9547 mL	14.7737 mL	29.5473 mL	147.7367 mL
5 mM	0.5909 mL	2.9547 mL	5.9095 mL	29.5473 mL
10 mM	0.2955 mL	1.4774 mL	2.9547 mL	14.7737 mL
20 mM	0.1477 mL	0.7387 mL	1.4774 mL	7.3868 mL
50 mM	0.0591 mL	0.2955 mL	0.5909 mL	2.9547 mL
100 mM	0.0295 mL	0.1477 mL	0.2955 mL	1.4774 mL