规格

价格

库存

数量

25 mg

¥ 19,400

10-14周

50 mg

¥ 25,800

10-14周

100 mg

¥ 33,500

10-14周

生物活性

产品描述

BMS-751324, a p38α MAPK inhibitor, features a carbamyl-methyl linkage precursor with esters and phosphate functional groups from hydroxyphenylacetic acid (HPA). It effectively reduces foot swelling and suppresses LPS-induced TNFα production in an arthritic rat model.

体外活性

VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.[1]
VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection.[4]
VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.[5]

化学信息

分子量	694.63
分子式	C₃₂H₃₅N₆O₁₀P
CAS No.	948842-66-8
Smiles	N(C=1C=2N(C=C(C(N(C(OCOC(CC3=CC=C(OP(=O)(O)O)C=C3)=O)=O)CCC)=O)C2C)N=CN1)C4=CC(C(NC5CC5)=O)=CC=C4C