Physostigmine Salicylate

Name: Physostigmine Salicylate
Brand: TargetMol
SKU: T0130
Price: 397 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T0130Cas号 57-64-7

别名 水杨酸依色林, 水杨酸毒扁豆碱

Physostigmine salicylate 是一种可逆的乙酰胆碱酯酶抑制剂，也一种是抗胆碱能中毒的解毒剂。它可透过血脑屏障并刺激中枢胆碱能神经传递。它能逆转阿尔茨海默病转基因小鼠的记忆缺陷。

Physostigmine Salicylate

一键复制产品信息

很棒

纯度: 99.86%

货号 T0130 别名 水杨酸依色林, 水杨酸毒扁豆碱Cas号 57-64-7

规格	价格	库存
1 mg	¥ 397	现货
5 mg	¥ 899	现货
10 mg	¥ 1,520	现货
25 mg	¥ 2,950	现货
50 mg	¥ 4,530	现货
1 mL x 10 mM (in DMSO)	¥ 846	现货

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产品介绍

Physostigmine Salicylate AI Summary

Physostigmine Salicylate exhibits strong bioactivity and potent inhibition properties across multiple targets. It inhibits human erythrocyte Acetylcholinesterase (AChE) with an IC50 value of 28.0 nM and human plasma Butyrylcholinesterase (BChE) with an IC50 value of 16.0 nM, showing a moderate selectivity value of 2.0. Additionally, it inhibits Torpedo california AChE with an IC50 of 21.3 nM, displaying concentration-dependent inhibition ranging from 24.71% to 64.3% at different concentrations (7.56 nM to 30.3 nM). The compound also demonstrates reversible mixed-type inhibition of electric eel acetylcholinesterase with a Ki value of 210.0 nM. Beyond cholinesterase inhibition, Physostigmine Salicylate shows various bioactivities, including: 1. Potent inhibition of Human Jumonji Domain Containing 2E (JMJD2E). 2. Enhancement of SMN2 splice variant expression. 3. Agonistic and antagonistic properties on the Hypoxia Response Element Signaling Pathway. 4. Inhibition of Aldehyde Dehydrogenase 1 (ALDH1A1) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). 5. Inhibition of Chronic Active B-Cell Receptor Signaling and the malarial parasite plastid with delayed death activity. 6. Substrate-like properties for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). 7. Inducing DNA re-replication in MCF 10a normal breast cells and inhibiting Glutaminase (GLS). 8. Inducing synthetic lethality in tumor cells producing 2HG, specifically in the HT-1080-NT fibrosarcoma cell line. Furthermore, Physostigmine Salicylate inhibits sodium fluorescein uptake in both OATP1B1 and OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 µM, with inhibition percentages of 115.97% and 110.77%, respectively, suggesting a high affinity for these transporters..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
别名	水杨酸依色林, 水杨酸毒扁豆碱

化学信息

分子量	413.48
分子式	C₂₂H₂₇N₃O₅
CAS No.	57-64-7
Smiles	OC(=O)c1ccccc1O.[H][C@]12N(C)CC[C@@]1(C)c1cc(OC(=O)NC)ccc1N2C
密度	no data available

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (302.31 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.84 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4185 mL	12.0925 mL	24.1850 mL	120.9248 mL
5 mM	0.4837 mL	2.4185 mL	4.8370 mL	24.1850 mL
10 mM	0.2418 mL	1.2092 mL	2.4185 mL	12.0925 mL
20 mM	0.1209 mL	0.6046 mL	1.2092 mL	6.0462 mL
50 mM	0.0484 mL	0.2418 mL	0.4837 mL	2.4185 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2092 mL