规格

价格

库存

数量

1 mg

¥ 1,380

1-2周

5 mg

¥ 2,980

1-2周

10 mg

¥ 4,480

1-2周

生物活性

产品描述	L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.
靶点活性	sTWEAK:7.8 µM
体外活性	L524-0366通过TAC减轻了不良重塑。TWEAK通过部分激活非典型NF-κB信号传导，诱导了来自WT但不是Fn14-/-纤维细胞的促炎症趋化因子，单核细胞趋化蛋白1的分泌。最终，在TAC后的小鼠以及人类衰竭心脏中，发现Fn14表达增加。
细胞实验	Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.
别名	[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone

化学信息

储存&溶解度

存储

Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 25 mg/mL (80.96 mM), Sonication is recommended.

体内实验配方

5% DMSO+95% Corn oil: 1 mg/mL (3.24 mM), Suspension.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

L524-0366