Name: AMY-101 TFA
Brand: TargetMol
SKU: TP2139L
Price: 993 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 993

现货

生物活性

产品描述	AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2.
靶点活性	C3:0.5 nM (kd)
体内活性	方法：AMY-101 TFA (4 mg/kg，皮下注射，每 24 小时一次， 28 天) 治疗小鼠，测试了 AMY-101 TFA 在全身给药时是否有效结果：AMY-101 TFA 导致 PPD 显着且持久地降低，PPD 是衡量组织破坏的指标。[1]
动物实验	Animal Model: Fifteen adult male cynomolgus monkeys (7–15 years old; 5.0–7.6 kg). Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution. Administration: Injected locally (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment) [1].
别名	Cp40 TFA, AMY-101 三氟乙酸盐

化学信息

分子量	1903.11
分子式	C₈₅H₁₁₈F₃N₂₃O₂₀S₂
CAS No.	1789738-04-0
Smiles	C(C(O)=O)(F)(F)F.C(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(=O)N(C)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(N([C@@H]([C@H](CC)C)C(N)=O)C)=O)CSSC[C@H](NC([C@@H](NC([C@@H](CC7=CC=C(O)C=C7)N)=O)[C@H](CC)C)=O)C(=O)N[C@@H]([C@@H](C)C)C(=O)N3
密度	no data available
Sequence	{D-Tyr}-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)
Sequence Short	{D-Tyr}-ICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)