规格

价格

库存

数量

5 mg

¥ 5,700

待询

10 mg

¥ 9,150

待询

25 mg

¥ 16,500

待询

1 mL x 10 mM (in DMSO)

¥ 6,698

待询

生物活性

产品描述	PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].
体外活性	PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].

化学信息

分子量	889.01
分子式	C₄₃H₄₈N₆O₁₁S₂
CAS No.	2089205-64-9
Smiles	CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ccnc2cc1OCCOCCOCCOCCOCC(=O)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (112.48 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (5.62 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1248 mL	5.6242 mL	11.2485 mL	56.2423 mL
5 mM	0.2250 mL	1.1248 mL	2.2497 mL	11.2485 mL
10 mM	0.1125 mL	0.5624 mL	1.1248 mL	5.6242 mL
20 mM	0.0562 mL	0.2812 mL	0.5624 mL	2.8121 mL
50 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1248 mL
100 mM	0.0112 mL	0.0562 mL	0.1125 mL	0.5624 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

PROTAC RIPK degrader-6

PROTAC RIPK degrader-6

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

PROTAC RIPK degrader-6

PROTAC RIPK degrader-6