购物车

您的购物车当前为空

Hyodeoxycholic acid

Name: Hyodeoxycholic acid
Brand: TargetMol
SKU: T2968
Price: 140 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.82%

货号 T2968Cas号 83-49-8

别名 猪去氧胆酸, α-Hyodeoxycholic Acid, NSC 60672, HDCA

Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸，是TGR5(GPCR19)的激动剂， CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。

Hyodeoxycholic acid

一键复制产品信息

很棒

纯度: 98.82%

货号 T2968 别名 猪去氧胆酸, α-Hyodeoxycholic Acid, NSC 60672, HDCACas号 83-49-8

Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸，是TGR5(GPCR19)的激动剂， CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。

规格	价格	库存
25 mg	¥ 140	现货
50 mg	¥ 190	现货
100 mg	¥ 328	现货
500 mg	¥ 797	现货
1 g	¥ 969	现货
1 mL x 10 mM (in DMSO)	¥ 163	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.82%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Hyodeoxycholic acid AI Summary

Hyodeoxycholic acid exhibits diverse biological activities across multiple domains. It shows strong binding affinity (210,000 Kb M-1) and a sensitivity change (0.4) towards cyclodextrin-conjugated peptide (with pyrene) at 25°C. Notably, it inhibits glucuronosyltransferase activity in human colon cancer cell line HT-29 at 5 µM concentration with 75.2% activity. The compound is highly soluble in water (15,000 nM) and forms micelles at a Critical Micellar Concentration of 14.0 mM with pH stability varying at a pKa of 5.0 and a critical micellar pH of 8.1. It has high lipophilicity with a logP of 4.27 and a relative lipophilicity value of 0.89. In terms of receptor activity, Hyodeoxycholic acid acts as an agonist at human TGR5 in CHO cells (EC50 of 31,600 nM) with 79.7% efficacy relative to lithocholic acid. It exhibits cytotoxic effects in human HET-1A and HuH7 cells (500 µM) with 0.882% and 0.738% activity, respectively. The compound demonstrates varying activities against different isoforms of UDP-glucuronosyltransferases (UGTs), showing higher activity with UGT1A8 and UGT2B7. It is also a substrate for Oatp1 transport protein with a Km value of 17,500 nM in Oatp1-expressing HeLa cells. Hyodeoxycholic acid exhibits antiplasmodial activity against Plasmodium falciparum 3D7, antitrypanosomal activity against Trypanosoma brucei brucei, and cytotoxicity against human WI38 cells. It has agonistic and antagonistic activities based on VDR-LBD and VP16 tagged-VDR-LBD assays, with EC50 and IC50 values greater than 150,000 nM and 50,000 nM, respectively. Additionally, it demonstrates antibacterial activity against Clostridium difficile NAP1 with 500 µM required for inhibition, antiviral efficacy against SARS-CoV-2 by reducing cytotoxicity in VERO-6 and Caco-2 cells at 10 µM, and inhibiting the SARS-CoV-2 3CL-Pro protease by -1.852% at 20 µM. Lastly, it shows weak inhibitory activity on human HDAC6 with commercial and custom peptide substrates (-3.31% and -1.14%)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
靶点活性	TGR5/GPCR19:31.6 µM(EC50)
别名	猪去氧胆酸, α-Hyodeoxycholic Acid, NSC 60672, HDCA

化学信息

分子量	392.57
分子式	C₂₄H₄₀O₄
CAS No.	83-49-8
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](O)[C@]2([H])C[C@H](O)CC[C@]12C
密度	0.9985 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (127.37 mM), Sonication is recommended.

Ethanol: 72 mg/mL (183.41 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.09 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5473 mL	12.7366 mL	25.4732 mL	127.3658 mL
5 mM	0.5095 mL	2.5473 mL	5.0946 mL	25.4732 mL
10 mM	0.2547 mL	1.2737 mL	2.5473 mL	12.7366 mL
20 mM	0.1274 mL	0.6368 mL	1.2737 mL	6.3683 mL
50 mM	0.0509 mL	0.2547 mL	0.5095 mL	2.5473 mL
100 mM	0.0255 mL	0.1274 mL	0.2547 mL	1.2737 mL