Oxalomalic acid (Oxalomalate) trisodium, an inhibitor of aconitase and NADP-dependent isocitrate dehydrogenase, suppresses nitrite production and inducible nitric oxide synthase (iNOS) protein expression in lipopolysaccharide-activated J774 macrophages [1].

Oxalomalic acid trisodium（2.2, 5 mM; 2+24 h）能够降低J774细胞在LPS刺激下亚硝酸盐的产生以及iNOS蛋白的表达[1]。同样，Oxalomalic acid trisodium（5 mM; 6, 12 h）对LPS诱导的J774巨噬细胞中iNOS mRNA表达无显著影响[1]。