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顶部产品介绍化学信息储存和溶解信息计算器

HPI-1 (hydrate)

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货号 T35538Cas号 1262770-72-8

别名 HPI-1 hydrate

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1

HPI-1 (hydrate)
其他形式的 “HPI-1 (hydrate)”:
HPi1
HPI 1

HPI-1 (hydrate)

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货号 T35538 别名 HPI-1 hydrateCas号 1262770-72-8

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1

规格价格库存数量
25 mg
¥ 10,600
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50 mg
¥ 13,800
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产品介绍

生物活性
产品描述
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1
别名HPI-1 hydrate
化学信息
分子量481.54
分子式C27H31NO7
CAS No.1262770-72-8
SmilesO=C(OCCOC)C1=C(NC2=C(C(=O)CC(C=3C=CC=CC3OC)C2)C1C=4C=CC=C(O)C4)C.O
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 3 mg/mL (6.23 mM), Sonication is recommended.
DMF: 10 mg/mL (20.77 mM), Sonication is recommended.
Ethanol: 20 mg/mL (41.53 mM), Sonication is recommended.
溶液配制表
DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.0767 mL10.3834 mL20.7667 mL103.8335 mL
5 mM0.4153 mL2.0767 mL4.1533 mL20.7667 mL
DMF/Ethanol
1mg5mg10mg50mg
10 mM0.2077 mL1.0383 mL2.0767 mL10.3834 mL
20 mM0.1038 mL0.5192 mL1.0383 mL5.1917 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

HPI-1 HydrateHPI1 HydrateHPI1 (hydrate)HPI-1HPI1HPI 1 HydrateHPI 1 (hydrate)HPI 1
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