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ABBV-744

Name: ABBV-744
Brand: TargetMol
SKU: T4697
Price: 377 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.79%

货号 T4697Cas号 2138861-99-9

别名 ABBV744

ABBV-744 是一种 BDII 选择性 BET 溴结构域抑制剂，可抑制 BRD2/3/4。它可研究炎症性疾病、癌症和艾滋病。

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ABBV-744

一键复制产品信息

很棒

纯度: 99.79%

货号 T4697 别名 ABBV744Cas号 2138861-99-9

ABBV-744 是一种 BDII 选择性 BET 溴结构域抑制剂，可抑制 BRD2/3/4。它可研究炎症性疾病、癌症和艾滋病。

规格	价格	库存
1 mg	¥ 377	现货
2 mg	¥ 577	现货
5 mg	¥ 987	现货
10 mg	¥ 1,650	现货
25 mg	¥ 3,270	现货
50 mg	¥ 4,430	现货
100 mg	¥ 5,970	现货
200 mg	¥ 8,190	现货
500 mg	¥ 12,200	现货
1 mL x 10 mM (in DMSO)	¥ 1,120	现货

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纯度: 99.79%

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COA HNMR LCMS 产品操作手册

产品介绍

ABBV-744 AI Summary

ABBV-744 exhibits significant pharmacological properties, including antiviral activity against SARS-CoV-2 in the Vero E6 cell line with an IC50 value of approximately 3467368.5 nM and a selectivity ratio of 0.548, indicative of a favorable balance between viral inhibition and cytotoxicity. It also demonstrates potent bioactivity as a BET bromodomain inhibitor, showing high selectivity for BRD4 BD2 over BD1 with a Ki ratio of 330.0 and effective inhibition of BRD4 BD2 with a Ki of 1.6 nM. The compound has antiproliferative activity in SKM1 cells with an IC50 of 6.7 nM and favorable oral bioavailability ranging from 24.0% to 77.0% in multiple species. It inhibits BRD4 bromodomain 1 and 2 with IC50 values of 327.5 nM and 3.3 nM, respectively, and has antiproliferative effects on human MV4-11 cells with an IC50 value of 250.0 nM after 72 hours. ABBV-744 displays binding affinity to the BRD4 BD2 domain with an IC50 of 6.31 nM and the BD1 domain with an IC50 of 398.11 nM, exhibiting a selectivity index of 60.0 for BD2 over BD1. The compound has a solubility of 26.0 μg/mL, permeability of 413.0 nm/s, and a distribution coefficient (logD) of 5.1. In growth rate assays, the compound causes variable effects, exhibiting both inhibitory and stimulatory actions on cell viability. It has a dissociation constant (Kd) of 3300.0 nM for BRD4 BD1 and 2.1 nM for BRD4 BD2, reflecting a stronger interaction with BRD4 BD2, with the lowest IC50 for BRD4 BD2 inhibition at 0.65 nM. Additionally, it impacts the thermal stability of various protein domains, suggesting its potential to modulate protein stability. Overall, ABBV-744 is a promising candidate with potent antiviral, BET bromodomain inhibition, and antiproliferative properties, warranting further research for therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
靶点活性	BRD4 BD2:3 nM (Kd), BRD4 BD2:4 nM (IC50), BRD3 BD2:13 nM (IC50), BRDT BD2:18 nM (IC50), BRD2 BD2:8 nM (IC50)
别名	ABBV744

化学信息

分子量	491.55
分子式	C₂₈H₃₀FN₃O₄
CAS No.	2138861-99-9
Smiles	CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1C)C(C)(C)O
密度	1.262 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 230 mg/mL (467.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0344 mL	10.1719 mL	20.3438 mL	101.7191 mL
5 mM	0.4069 mL	2.0344 mL	4.0688 mL	20.3438 mL
10 mM	0.2034 mL	1.0172 mL	2.0344 mL	10.1719 mL
20 mM	0.1017 mL	0.5086 mL	1.0172 mL	5.0860 mL
50 mM	0.0407 mL	0.2034 mL	0.4069 mL	2.0344 mL
100 mM	0.0203 mL	0.1017 mL	0.2034 mL	1.0172 mL