GNE-207

Name: GNE-207
Brand: TargetMol
SKU: T15399
Rating: 4.5 (1 reviews)

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产品编号 T15399Cas号 2158266-58-9

GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).

GNE-207

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产品编号 T15399Cas号 2158266-58-9

规格	价格	库存
25 mg	¥ 15,000	8-10周
50 mg	¥ 19,800	8-10周
100 mg	¥ 25,500	8-10周

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产品介绍

生物活性

产品描述	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).
靶点活性	BRD41:3.1 μM, CBP:1 nM
体内活性	GNE-207 (5?mg/kg) displays moderate clearance in PK. It has an acceptable oral bioavailability.

化学信息

分子量	510.59
分子式	C₂₉H₃₀N₆O₃
CAS No.	2158266-58-9
密度	1.38 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (391.70 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9585 mL	9.7926 mL	19.5852 mL	97.9259 mL
5 mM	0.3917 mL	1.9585 mL	3.9170 mL	19.5852 mL
10 mM	0.1959 mL	0.9793 mL	1.9585 mL	9.7926 mL
20 mM	0.0979 mL	0.4896 mL	0.9793 mL	4.8963 mL
50 mM	0.0392 mL	0.1959 mL	0.3917 mL	1.9585 mL
100 mM	0.0196 mL	0.0979 mL	0.1959 mL	0.9793 mL