Pyrantel pamoate

Name: Pyrantel pamoate
Brand: TargetMol
SKU: T1259
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.71%

货号 T1259Cas号 22204-24-6

别名 双羟萘酸噻嘧啶, Pyrantel embonate

Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。

Pyrantel pamoate

一键复制产品信息

很棒

纯度: 99.71%

货号 T1259 别名 双羟萘酸噻嘧啶, Pyrantel embonateCas号 22204-24-6

Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。

规格	价格	库存
50 mg	¥ 123	现货
100 mg	¥ 163	现货
500 mg	¥ 413	现货
1 g	¥ 588	现货
1 mL x 10 mM (in DMSO)	¥ 138	现货

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产品介绍

Pyrantel pamoate AI Summary

Pyrantel pamoate demonstrates diverse bioactivities, functioning as both an inhibitor and an activator across various biological pathways and processes. It is a potent inhibitor of Human Galactosidase (GALK) and HSD17B4 with potencies of 42,128.5 nM and 31,622.8 nM, respectively. It inhibits Tau Fibril Formation with potencies of 15,848.9 nM and 14,125.4 nM via fluorescence polarization and Thioflavin T Binding, respectively. It shows inhibition of 15-hLO and 15-hLO-2 with potencies ranging from 25,059.4 nM to 31,622.8 nM, and inhibits Menin-MLL interaction in MLL-related leukemias at 14,125.4 nM. It is also an inhibitor of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia at 25,059.4 nM potency. Additionally, Pyrantel pamoate acts as an activator and substrate of Cytochrome P450 3A4 at 25,118.9 nM potency. It inhibits the vitamin D receptor (VDR), Polymerase Kappa, and USP1/UAF1, with respective potencies of 35,481.3 nM, 31,622.8 nM, and 50,118.7 nM. In terms of antiparasitic activity, Pyrantel pamoate acts effectively against Ancylostoma caninum isolates NT and PR, with an EC50 of 217,200.0 nM for isolate NT and 681,300.0 nM for isolate PR, and exhibits notable larval arrested morphology effects. Moreover, the compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, with inhibition percentages of 31.41% and 34.84% at 10 µM concentration. It also displays antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells, with an inhibition of -1.07% in Caco-2 cells and -0.17% in VERO-6 cells at 10 µM concentration. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease activity by 16.14% at 20 µM. Overall, Pyrantel pamoate shows potential as a multi-faceted therapeutic agent with activities spanning from enzyme inhibition and receptor modulation to antiparasitic and antiviral effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.
别名	双羟萘酸噻嘧啶, Pyrantel embonate

化学信息

分子量	594.69
分子式	C₃₄H₃₀N₂O₆S
CAS No.	22204-24-6
Smiles	C1(=NCCCN1C)/C=C/c1cccs1.C(c1c(c(cc2c1cccc2)C(=O)O)O)c1c(c(cc2c1cccc2)C(=O)O)O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.67 mg/mL (28.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6815 mL	8.4077 mL	16.8155 mL	84.0774 mL
5 mM	0.3363 mL	1.6815 mL	3.3631 mL	16.8155 mL
10 mM	0.1682 mL	0.8408 mL	1.6815 mL	8.4077 mL
20 mM	0.0841 mL	0.4204 mL	0.8408 mL	4.2039 mL