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Pyrantel pamoate

Name: Pyrantel pamoate
Brand: TargetMol
SKU: T1259
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.71%

货号 T1259Cas号 22204-24-6

别名 双羟萘酸噻嘧啶, Pyrantel embonate

Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。

Pyrantel pamoate

一键复制产品信息

很棒

纯度: 99.71%

货号 T1259 别名 双羟萘酸噻嘧啶, Pyrantel embonateCas号 22204-24-6

Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。

规格	价格	库存
50 mg	¥ 123	现货
100 mg	¥ 163	现货
500 mg	¥ 413	现货
1 g	¥ 588	现货
1 mL x 10 mM (in DMSO)	¥ 138	现货

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实验操作小课堂

常见问题解答

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纯度: 99.71%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Pyrantel pamoate AI Summary

Pyrantel pamoate demonstrates diverse bioactivities, functioning as both an inhibitor and an activator across various biological pathways and processes. It is a potent inhibitor of Human Galactosidase (GALK) and HSD17B4 with potencies of 42,128.5 nM and 31,622.8 nM, respectively. It inhibits Tau Fibril Formation with potencies of 15,848.9 nM and 14,125.4 nM via fluorescence polarization and Thioflavin T Binding, respectively. It shows inhibition of 15-hLO and 15-hLO-2 with potencies ranging from 25,059.4 nM to 31,622.8 nM, and inhibits Menin-MLL interaction in MLL-related leukemias at 14,125.4 nM. It is also an inhibitor of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia at 25,059.4 nM potency. Additionally, Pyrantel pamoate acts as an activator and substrate of Cytochrome P450 3A4 at 25,118.9 nM potency. It inhibits the vitamin D receptor (VDR), Polymerase Kappa, and USP1/UAF1, with respective potencies of 35,481.3 nM, 31,622.8 nM, and 50,118.7 nM. In terms of antiparasitic activity, Pyrantel pamoate acts effectively against Ancylostoma caninum isolates NT and PR, with an EC50 of 217,200.0 nM for isolate NT and 681,300.0 nM for isolate PR, and exhibits notable larval arrested morphology effects. Moreover, the compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, with inhibition percentages of 31.41% and 34.84% at 10 µM concentration. It also displays antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells, with an inhibition of -1.07% in Caco-2 cells and -0.17% in VERO-6 cells at 10 µM concentration. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease activity by 16.14% at 20 µM. Overall, Pyrantel pamoate shows potential as a multi-faceted therapeutic agent with activities spanning from enzyme inhibition and receptor modulation to antiparasitic and antiviral effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.
别名	双羟萘酸噻嘧啶, Pyrantel embonate

化学信息

分子量	594.69
分子式	C₃₄H₃₀N₂O₆S
CAS No.	22204-24-6
Smiles	C1(=NCCCN1C)/C=C/c1cccs1.C(c1c(c(cc2c1cccc2)C(=O)O)O)c1c(c(cc2c1cccc2)C(=O)O)O
密度	no data available

储存&溶解度

存储

溶解度信息

DMSO: 16.67 mg/mL (28.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6815 mL	8.4077 mL	16.8155 mL	84.0774 mL
5 mM	0.3363 mL	1.6815 mL	3.3631 mL	16.8155 mL
10 mM	0.1682 mL	0.8408 mL	1.6815 mL	8.4077 mL
20 mM	0.0841 mL	0.4204 mL	0.8408 mL	4.2039 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

trichinosis Pyrantel pamoate Pyrantel pinworm parasitic infection Parasite Nicotinic acetylcholine receptors nAChR Inhibitor inhibit hookworm ascariasis Antiparasitic Antibiotic

Pyrantel pamoate

Pyrantel pamoate