规格

价格

库存

数量

1 mg

¥ 446

现货

5 mg

¥ 1,320

现货

10 mg

¥ 2,480

现货

25 mg

¥ 3,560

现货

50 mg

¥ 5,130

现货

100 mg

¥ 6,780

现货

200 mg

¥ 9,170

现货

1 mL x 10 mM (in DMSO)

¥ 1,450

现货

生物活性

产品描述	PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
靶点活性	Pin1:72.3 nM
体外活性	PIN1抑制剂API-1显著抑制了SK-Hep-1、SNU-423和Hep3B细胞增殖，其半抑制浓度(IC50)范围为0.683-4.16 μM[1]。
体内活性	PIN1 inhibitor API-1 通过在小鼠中上调成熟miRNA的生物合成来抑制肿瘤生长[1]。

化学信息

分子量	366.3
分子式	C₁₅H₁₃F₃N₆O₂
CAS No.	680622-70-2
Smiles	Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1
密度	1.525 g/cm3 (Predicted)
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (682.5 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO